Tandem Benzannulation Ring Closing Metathesis Strategy For The Synthesis Of Benzo Fused Nitrogen Heterocycles PDF Download
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| Author | : Xiao Yin Mak |
| Publisher | : |
| Total Pages | : 622 |
| Release | : 2008 |
| Genre | : |
| ISBN | : |
Download Tandem Benzannulation-ring Closing Metathesis Strategy for the Synthesis of Benzo-fused Nitrogen Heterocycles Book in PDF, ePub and Kindle
A tandem benzannulation-ring closing metathesis strategy for the efficient synthesis of benzo-fused nitrogen heterocycles such as dihydroquinolines, benzazepines, and benzazocines has been developed. This strategy is based on the benzannulation reaction of ynamides with cyclobutenones or [alpha]-diazo ketones to generate highly-substituted aniline derivatives, which then participate in ring-closing metathesis reactions to form nitrogen heterocycles. The synthetic utility of this strategy has been demonstrated by its successful application in a formal synthesis of the natural product (+)-FR900482. In addition, an environmentally-friendly approach to the synthesis of amides and lactams has been developed using supercritical carbon dioxide as a 'green' replacement solvent. The amide products are generated from the addition of amines to ketenes, which are formed in situ from the retro-ene reaction of alkynyl ethers.
| Author | : Thomas Paul Willumstad |
| Publisher | : |
| Total Pages | : 345 |
| Release | : 2013 |
| Genre | : |
| ISBN | : |
Download Synthesis of Highly Substituted Benzo-fused Nitrogen Heterocycles Via Tandem Benzannulation/cyclization Strategies Book in PDF, ePub and Kindle
Benzannulations employing ynamides and vinylketenes (generated in situ from [alpha]-diazo ketones) were investigated. Irradiation of the diazo ketones using a batch or continuous-flow reactor leads to the formation of vinylketenes via a photo-Wolff rearrangement. The vinylketenes then react with ynamides via a pericyclic cascade process to produce highly substituted aniline derivatives. Using this vinylketene-based benzannulation, tandem strategies for the synthesis of highly substituted benzo-fused nitrogen heterocycles were investigated. A tandem benzannulation-iodocyclization method for the synthesis of polysubstituted quinolines was established. In addition, a tandem strategy for the synthesis of carbazoles was developed and applied in the total synthesis of the carbazole alkaloid carazostatin as well as formal syntheses of the alkaloids carbazoquinocin C and antiostatin A4.
| Author | : Aimee Lynn Crombie |
| Publisher | : |
| Total Pages | : 355 |
| Release | : 2004 |
| Genre | : |
| ISBN | : |
Download Annulation Strategies for the Synthesis of Azulenes and Polycyclic Nitrogen Heterocycles Book in PDF, ePub and Kindle
Highly convergent annulation strategies have been developed for the synthesis of azulenes and polycyclic nitrogen heterocycles. Specifically, substituted azulenes have been synthesized via a ring expansion-annulation strategy based on n-halo diazo ketones. The method employs the use of readily available benzenoid starting materials and achieves the synthesis of azulenes substituted on both the five- and seven-membered rings regioselectively. The synthetic utility of the ring expansion annulation products, in particular azulenyl halides and triflates, has been demonstrated by their successful application in transition metal-mediated carbon-carbon bond forming reactions. These reactions have been used to further functionalize the five- and seven-membered rings and also in the synthesis of oligoazulenes and azulenylamino acid derivatives. In addition, polycyclic nitrogen heterocycles have been synthesized via a tandem ring forming strategy. The strategy employs a novel benzannulation reaction of substituted cyclobutenones with ynamides, which are synthesized via the strategy for the N-alkynylation of amides strategy developed in the Danheiser laboratory. The products of these benzannulation reactions, highly-substituted anilines, then participate in ring closing metathesis reactions to form various nitrogen heterocycles. In particular dihydroquinolines, hydrobenzoazepines, and hydrobenzoazocines were synthesized via this tandem ynamide benzannulation ring closing metathesis strategy.
| Author | : Navjeet Kaur |
| Publisher | : Elsevier |
| Total Pages | : 566 |
| Release | : 2023-02-21 |
| Genre | : Science |
| ISBN | : 032395653X |
Download 8-Membered Heterocycle Synthesis Book in PDF, ePub and Kindle
8-Membered Heterocycle Synthesis focuses on both the new and established methods for the synthesis of various 8-membered heterocycles. 8-membered heterocyclic compounds act as target molecules for a wide range of synthetic studies and are present in a broad range of natural products, showing a wide variety of pharmaceutical and biological properties. Covering an important and rapidly growing branch of heterocyclic chemistry, this book brings together every protocol for the synthesis of 8-membered heterocycles in one place, allowing the reader to see all the possibilities for making a particular compound using one particular reagent. Providing up-to-date and comprehensive information about the synthesis of medium-ring heterocycles and the latest information on this fast-moving field, with easy access to the synthetic protocols for different 8-membered heterocycles, case studies, and application, this book will be essential reading for students, pharmacologists, biochemists, organic and medicinal chemists, researchers, and academic professionals. Covers the different methodologies for the synthesis of eight-membered heterocycles Includes summary schemes for each type of heterocycle, giving an overview of all the reactants that can be used, and the experimental conditions Includes discussion of the applications of eight-membered heterocycles
| Author | : Laszlo Kurti |
| Publisher | : Elsevier |
| Total Pages | : 808 |
| Release | : 2005-04-29 |
| Genre | : Science |
| ISBN | : 0080575412 |
Download Strategic Applications of Named Reactions in Organic Synthesis Book in PDF, ePub and Kindle
Kurti and Czako have produced an indispensable tool for specialists and non-specialists in organic chemistry. This innovative reference work includes 250 organic reactions and their strategic use in the synthesis of complex natural and unnatural products. Reactions are thoroughly discussed in a convenient, two-page layout--using full color. Its comprehensive coverage, superb organization, quality of presentation, and wealth of references, make this a necessity for every organic chemist. * The first reference work on named reactions to present colored schemes for easier understanding* 250 frequently used named reactions are presented in a convenient two-page layout with numerous examples* An opening list of abbreviations includes both structures and chemical names * Contains more than 10,000 references grouped by seminal papers, reviews, modifications, and theoretical works * Appendices list reactions in order of discovery, group by contemporary usage, and provide additional study tools* Extensive index quickly locates information using words found in text and drawings
| Author | : Akkattu T. Biju |
| Publisher | : John Wiley & Sons |
| Total Pages | : 530 |
| Release | : 2021-08-23 |
| Genre | : Science |
| ISBN | : 3527346465 |
Download Modern Aryne Chemistry Book in PDF, ePub and Kindle
A groundbreaking book to offer a a comprehensive account of important reactions involving arynes Modern Aryne Chemistry is the first book on the market to offer a conceptual framework to the reactions related to arynes. It also provides a systematic introduction to the cycloaddition reactions, insertion reactions and transition-metal-catalyzed transformations of arynes. The author, a noted expert on the topic, highlights a novel strategy for carbon-carbon and carbon-heteroatom bond construction using arynes. The book reveiws the recent use of aryne chemistry for the development of new multicomponent reactions. New advances in this area has shown rapid emergence of a new class of reactions classified under rearrangement reactions. The author also includes information on aryne methods that have been employed for the synthesis of several natural products. The simplicity and sophistication of the synthetic strategy using arynes can serve as a springboard for organic chemists to explore new possibilities and imagine applications of the concept of arynes. This important book: Presents a one-of-kind comprehensive guide to arynes reactions Offers a proven approach to the synthesis of natural product and polymers Reviews the most recent developments in the carbon-carbon and carbon-heteroatom bond-forming reactions involving arynes Written for organic, pharmaceutical, medicinal, natural products, and catalytic Chemists, Modern Aryne Chemistry offers a comprehensive review of the fundamentals of reactions related to arynes and the most recent developments in the field.
| Author | : Brian Robinson |
| Publisher | : |
| Total Pages | : |
| Release | : 1990 |
| Genre | : |
| ISBN | : |
Download The Fischer Indole Synthesis Book in PDF, ePub and Kindle
| Author | : Martin Hiersemann |
| Publisher | : John Wiley & Sons |
| Total Pages | : 591 |
| Release | : 2007-02-27 |
| Genre | : Science |
| ISBN | : 3527610553 |
Download The Claisen Rearrangement Book in PDF, ePub and Kindle
The first comprehensive coverage of all facets of the Claisen rearrangement and its variants. As such, this book helps synthetic chemists to exploit the vast potential of this elegant C-C linking reaction, discusses a wealth of catalytic options, and gives those more theory-minded chemists a detailed insight into the mechanistic aspects of the Claisen rearrangement. An invaluable source of information and a ready reference for all organic and catalytic chemists, as well as those working with/on organometallics, and in industry.
| Author | : George S. Zweifel |
| Publisher | : John Wiley & Sons |
| Total Pages | : 416 |
| Release | : 2017-03-13 |
| Genre | : Science |
| ISBN | : 1119086760 |
Download Modern Organic Synthesis Book in PDF, ePub and Kindle
This book bridges the gap between sophomore and advanced / graduate level organic chemistry courses, providing students with a necessary background to begin research in either an industry or academic environment. • Covers key concepts that include retrosynthesis, conformational analysis, and functional group transformations as well as presents the latest developments in organometallic chemistry and C–C bond formation • Uses a concise and easy-to-read style, with many illustrated examples • Updates material, examples, and references from the first edition • Adds coverage of organocatalysts and organometallic reagents
| Author | : Bernhard Grimm |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 603 |
| Release | : 2007-03-14 |
| Genre | : Science |
| ISBN | : 1402045166 |
Download Chlorophylls and Bacteriochlorophylls Book in PDF, ePub and Kindle
The first dedicated new work since 1991, this book reviews recent progress and current studies in the chemistry, metabolism and spectroscopy of chlorophylls, bacteriochlorophylls and their protein complexes. Also discussed is progress on the applications of chlorophylls as photosensitizers in photodynamic therapy of cancerous tumours, and as molecular probes in biochemistry, medicine, plant physiology, ecology and geochemistry. Each section offers an introductory overview followed by concise, focused and fully-referenced chapters written by experts.
