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| Author | : G. G. Furin |
| Publisher | : Taylor & Francis US |
| Total Pages | : 158 |
| Release | : 1991 |
| Genre | : Science |
| ISBN | : 9783718651573 |
| Author | : Richard D. Chambers |
| Publisher | : CRC Press |
| Total Pages | : 426 |
| Release | : 2004 |
| Genre | : Science |
| ISBN | : 9780849317903 |
The introduction of carbon-fluorine bonds into organic compounds can profoundly influence their chemical and physical properties when compared to their non-fluorine-containing analogues, leading to a range of man-made materials with highly desirable properties. These molecules are of interest across the wide spectrum of industrial and academic organic chemistry, from pharmaceuticals, through fine and specialty chemicals to polymers. From Prozac to Teflon, many of the most important products of the chemical and life-science industries rely on organic fluorine chemistry for their useful properties. This book covers both the preparative methodologies and chemical properties of partially and highly fluorinated organic systems.
| Author | : Atta-ur-Rahman |
| Publisher | : Bentham Science Publishers |
| Total Pages | : 594 |
| Release | : 2011-01-10 |
| Genre | : Science |
| ISBN | : 1608051986 |
"The volume focuses on recent advances in organofluorine chemistry directed towards selective fluorine introduction into various target molecules, employing both traditional and contemporary, electrophilic and nucleophilic, fluorinating agents. It brings t"
| Author | : L.A. Alekseeva |
| Publisher | : Springer |
| Total Pages | : 306 |
| Release | : 1989-11-02 |
| Genre | : Science |
| ISBN | : |
The book summarizes and gives a critical analysis of the literature on the use of reactive covalent fluorides (organic and inorganic) for the synthesis of fluoroorganic compounds. New methods of using SF4 for the fluorination of complex polyfunctional organic compounds are described. The prospects are shown for the selective fluorinations of complex compounds with non-traditional fluorinating agents (halogen fluorides, XeF2, fluorosulphuranes, N-F- and O-F-containing compounds). The book gives recommendations for the practical use of these fluorides, and typical synthetic procedures. It introduces the beginner to modern methods of fluorination and helps qualified scientists and technologists to choose the optimal methods of synthesis. Using the fluorinating agents described in this book, it is possible to synthesize various fluorine-containing substances.
| Author | : Al Postigo |
| Publisher | : Elsevier |
| Total Pages | : 0 |
| Release | : 2018-09-10 |
| Genre | : Science |
| ISBN | : 9780128129586 |
Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates reviews how the use of these techniques on compounds with already known and relevant biological activity can provide new pharmaceutical leads with improved medicinal properties. The fluorination strategies discussed take into account both conventional and novel reagents, including nucleophilic, electrophilic, those of a radical nature, and diverse families of organic compounds, such as (hetero) aromatic rings and aliphatic substrates. Drawing on the authors' expert knowledge, this book provides researchers with a broad set of applicable methods to use in their work.
| Author | : Viacheslav A. Petrov |
| Publisher | : John Wiley & Sons |
| Total Pages | : 535 |
| Release | : 2009-09-22 |
| Genre | : Science |
| ISBN | : 047052894X |
A thorough survey of synthetic methods, chemistry, and applications of major classes of fluorinated heterocycles Merging organic, heterocyclic, and fluoroorganic chemistry, fluorinated heterocyclic compounds have distinctively desirable properties suitable for use in pharmaceuticals and agrichemicals, especially their ability to penetrate the cell membrane barrier for drug absorption. Offering a needed overview of this relatively new addition to the heterocyclic family, this essential reference provides the latest state-of-the-art information on key application areas within fluorine chemistry. With contributions from experts from both industry and academia, the book covers the chemistry, synthesis, and applications of fluorinated heterocycles with chapters on: Three-, four-, five-, six-, and seven-membered fluorine-containing heterocycles Fluorinated nucleosides Fluorointermediates Applications of fluorinated heterocycles in agricultural products Pharmaceuticals containing fluorinated heterocycles Technical applications of fluorinated heterocycles Written by a team of world-recognized experts in the area of organic and industrial chemistry of fluorine, Fluorinated Heterocyclic Compounds: Synthesis, Chemistry, and Applications will prove valuable to both students and researchers from academia and industry seeking further knowledge of the synthetic methods, chemistry, and applications of major classes of fluorinated heterocycles.
| Author | : Dominique Cahard |
| Publisher | : John Wiley & Sons |
| Total Pages | : 870 |
| Release | : 2020-07-13 |
| Genre | : Science |
| ISBN | : 3527346813 |
A must-have resource for all the researchers working in the organofluorine and related fields This timely two-volume set uniquely focuses on emerging fluorinated motifs beyond R-CF3 and R-F, like R-CF2H, R-OCF3, R-SCF3 and R-SF5. It also offers descriptions of the properties, synthesis, and applications of these emerging fluorinated motifs in order to help readers design new chemical entities, while providing new interest for researchers in organofluorine chemistry and new tools for those in other areas. Emerging Fluorinated Motifs: Synthesis, Properties and Applications begins with a description of carbon-linked fluorine-containing groups that include monofluoromethyl and difluoromethyl groups. It then details combinations of heteroatoms, Oxygen, Sulfur, Selenium, Nitrogen, and Phosphorus with fluorine-containing groups, outlining subsections of the most popular current motifs. Fluoroalkyl ethers, thioethers, and the recent blossoming of the SF5 unit is covered. Other chapters look at: selenium-linked fluorine-containing motifs; construction of N?CF2H, N?CF3, N?CH2CF3 motifs; and the synthesis and applications of P¿Rf-containing molecules. -Focuses on the synthesis, properties, and applications of emerging fluorinated motifs -Covers carbon-linked fluorine-containing motifs, oxygen-linked fluorine-containing motifs, sulfur-linked fluorine-containing motifs, and more -Appeals to academic and industrial researchers working in organic chemistry, medicinal chemistry, food chemistry, and materials science -Edited by world-renowned experts in organofluorine chemistry Emerging Fluorinated Motifs is intended for academic research institutes, university libraries, researchers, graduate students, postdoctors, and researchers in the chemical industry.
| Author | : Jinbo Hu |
| Publisher | : Springer |
| Total Pages | : 0 |
| Release | : 2020-08-12 |
| Genre | : Science |
| ISBN | : 9789811038952 |
This volume reviews the recent advances in formation of C-F bonds and X-F bonds (X = heteroatom) to produce useful fluorinated molecules for pharmaceuticals, materials and more. Reactions and methods associated with fluorination, including monofluorination, difluorination, trifluorination and other polyfluorination that have emerged within the past few years are systematically discussed. With contributions from front-line researchers in this field from both academia and industry, this book provides a valuable resource for scholars, graduate students as well as professionals.
| Author | : Tamejiro Hiyama |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 281 |
| Release | : 2013-03-09 |
| Genre | : Science |
| ISBN | : 3662041642 |
In view of increasing interest in organofluorine compounds, this book was undertaken to describe biological and physical properties of organofluorine compounds, synthetic methods of these, their roles in pharmaceutical, agrochemical and material sciences. In particular, the book will emphasize on the usefulness of fluorination reaction, availability of fluorination agents, so that even graduate students who are unfamiliar to this field can understand and participate in this fascinating heteroatom chemistry.
| Author | : George A. Olah |
| Publisher | : Wiley-Interscience |
| Total Pages | : 416 |
| Release | : 1992-08-11 |
| Genre | : Science |
| ISBN | : 9780471543701 |
Leading investigators in their fields present a broad perspective of recent major research trends in synthetic fluorine chemistry. Coverage includes: various aspects of organic and inorganic fluorine chemistry, fluorination methods, organometallic fluorine chemistry and its use in synthesis, the synthesis of perfluoropolyethers (an extraordinary class of new fluorinated compounds) and much more.
