Synthesis Of 4 7 Disubstituted Derivatives Of Imidazo 45 D Pyridazine And Related Compounds PDF Download

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Azoles

Azoles
Author: Aleksey Kuznetsov
Publisher: BoD – Books on Demand
Total Pages: 148
Release: 2021-06-30
Genre: Science
ISBN: 1839681799

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Azoles are a broad and promising class of five-membered heterocyclic compounds containing from one up to five nitrogen atom(s) that can also contain sulfur or oxygen atoms. Widely used as potent antifungal agents, various azole derivatives have also demonstrated many other promising biological properties. This book covers studies of several types of thiazole-based heterocyclic scaffolds, the development of 4-thiazolidinone and thiazole derivatives with heterocyclic fragments as potential candidates for new drugs against trypanosomiasis, numerous synthetic approaches for the synthesis of 1,2,3-triazoles, the application of N-azole, N,S-azole, and N,O-azole as well as their derivatives as retarders of metallic corrosion, and the integration of azoles in materials used for renewable energy processing and applications and wood treatment.


Thiazole and Its Derivatives

Thiazole and Its Derivatives
Author: Jacques V. Metzger
Publisher:
Total Pages: 440
Release: 1979
Genre: Thiazoles
ISBN:

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Pyridines: From Lab to Production

Pyridines: From Lab to Production
Author: Eric F.V. Scriven
Publisher: Academic Press
Total Pages: 583
Release: 2013-01-08
Genre: Science
ISBN: 0123852366

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Pyridines: From Lab to Production provides a synthetic armory of tools to aid the practicing chemist by reviewing the most reliable historical methods alongside new methods/ Written by scientists who have actually used these in synthesis. By emphasizing tricks and tips to optimize reactions for the best yields and purity, which are often missing from the primary literature, this book provides another dimension for the synthetic chemist. A combined academic and industrial approach evaluates the best methods for different scales of reaction and discusses practical tips (e.g. when to stop a reaction early to maximize purity or when to re-use side products). Chapters also assess whether to make or source starting materials, how to connect them and what are the best synthetic routes. The book is designed to be a stand-alone reference, but also provides cross references to leading reviews and the Comprehensive Heterocyclic Chemistry reference works for those who want to learn more. Reviews tried and tested practical methods to help the reader select the best method for their research Includes tips, tricks and hints to enable the reader to get the best yield or cleanest product out of their reaction for synthesising or transforming a pyridine derivative Written by both academic researchers and industry leaders this provides a unique view of how to get the most out of a reaction no matter what scale you are running this on


Chemistry of 2-Oxoaldehydes and 2-Oxoacids

Chemistry of 2-Oxoaldehydes and 2-Oxoacids
Author: Atul Kumar
Publisher: Elsevier
Total Pages: 293
Release: 2021-09-28
Genre: Science
ISBN: 0128242868

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Chemistry of 2-Oxoaldehydes and 2-Oxoacids offers complete coverage on 2-oxoaldehydes and 2-oxoacid, which to date have not been covered in a comprehensive manner. Novel reactions related to 2-oxoaldehydes and 2-oxoacids on keto and aldehydic groups (both participating separately or in combination), decarboxylative reactions, spectral analysis and diverse applications are explored. The book is divided into two parts, with the first outlining methods for the preparation and physical properties of 2-Oxoaldehydes, along with the structure, spectral characteristics and reactivity of 2-Oxoaldehydes. The second part covers the preparation and physical properties of 2-Oxoacids and the synthesis of many related reactions. This book is essential reading for researchers working on these types of reactions in organic chemistry, medicinal chemistry, natural product chemistry and pharmaceutical chemistry. Covers various synthetic procedures for the synthesis of 2-Oxoaldehydes and 2-Oxoacids Provides information about different types of reactions, such as C-H activation reactions, coupling reactions, decarboxylative reactions, and nucleophilic reactions for the synthesis of different biologically active compounds Includes the use of 2-Oxoaldeehyde and 2-Oxoacid as the starting point for the synthesis of different synthons that can be used for various medicinally important compounds


Drug Monitoring and Clinical Chemistry

Drug Monitoring and Clinical Chemistry
Author: Georg Hempel
Publisher: Elsevier
Total Pages: 379
Release: 2004-05-15
Genre: Science
ISBN: 0080530540

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Drug Monitoring and Clinical Chemistry, the 5th volume in the Handbook of Analytical Separations series, gives an overview about methods to analyse drugs in biological fluids. The most widely used methods to analyse drugs in biological fluids. i.e. chromatographic methods, CE and immunoassays are described in detail. For important drugs, an overview about the methods available and a comparison of the techniques should be given to enable the reader to choose the right method depending on laboratory equipment, staff, the aim of the investigation etc. Other general aspects important for conducting therapeutic drug monitoring or pharmacokinetics studies are also covered, i.e. sample preparation, validation of the analytical methods and pharmacokinetic methods for interpreting the data. Areas where therapeutic drug monitoring is used frequently such as antibiotics, immunosuppressant drugs, antipsychotic and anticancer drugs will be discussed in detail. In addition, the important field of phenotyping and genotyping for therapy optimisation with special focus on real-life applications is also covered. The book contains important information for analyst working on drug analysis in clinical chemistry, hospital pharmacists involved in therapeutic drug monitoring, other pharmacists, chemists or physicians working on pharmacokinetic studies in industry or academia. In contrast to other books in this field, this book provides up-to-date information regarding both methodology and clinical applications. For the applications, only fields are described where therapeutic drug monitoring is used in clinical routine and provides benefit to the patients. Overview of all important field where therapeutic drug monitoring is applied All relevant analytical and computational methods are discussed Written by experts with a lot of practical experience in the field


Medicinal Chemistry Approaches to Malaria and Other Tropical Diseases

Medicinal Chemistry Approaches to Malaria and Other Tropical Diseases
Author:
Publisher: Academic Press
Total Pages: 232
Release: 2019-10-25
Genre: Medical
ISBN: 0128205512

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Medicinal Chemistry Approaches to Malaria and Other Tropical Disease, Volume 53 in the Annual Reports in Medicinal Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Annual Reports in Medicinal Chemistry series Includes the latest information on Medicinal Approaches to Malaria and Other Tropical Diseases


Bio-Based Solvents

Bio-Based Solvents
Author: François Jérôme
Publisher: John Wiley & Sons
Total Pages: 183
Release: 2017-06-29
Genre: Science
ISBN: 1119065445

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A multidisciplinary overview of bio-derived solvent applications, life cycle analysis, and strategies required for industrial commercialization This book provides the first and only comprehensive review of the state-of-the-science in bio-derived solvents. Drawing on their own pioneering work in the field, as well as an exhaustive survey of the world literature on the subject, the authors cover all the bases—from bio-derived solvent applications to life cycle analysis to strategies for industrial commercialization—for researchers and professional chemists working across a range of industries. In the increasingly critical area of sustainable chemistry, the search for new and better green solvents has become a top priority. Thanks to their renewability, biodegradability and low toxicity, as well as their potential to promote advantageous organic reactions, green solvents offer the promise of significantly reducing the pernicious effects of chemical processes on human health and the environment. Following an overview of the current solvents markets and the challenges and opportunities presented by bio-derived solvents, a series of dedicated chapters cover all significant classes of solvent arranged by origin and/or chemical structure. Throughout, real-world examples are used to help demonstrate the various advantages, drawbacks, and limitations of each class of solvent. Topics covered include: The commercial potential of various renewably sourced solvents, such as glycerol The various advantages and disadvantages of bio-derived versus petroleum-based solvents Renewably-sourced and waste-derived solvents in the design of eco-efficient processes Life cycle assessment and predictive methods for bio-based solvents Industrial and commercial viability of bio-based solvents now and in the years ahead Potential and limitations of methodologies involving bio-derived solvents New developments and emerging trends in the field and the shape of things to come Considering the vast potential for new and better products suggested by recent developments in this exciting field, Bio-Based Solvents will be a welcome resource among students and researchers in catalysis, organic synthesis, electrochemistry, and pharmaceuticals, as well as industrial chemists involved in manufacturing processes and formulation, and policy makers.


Metallomesogens

Metallomesogens
Author: Jose Luis Serrano
Publisher: John Wiley & Sons
Total Pages: 517
Release: 2008-09-26
Genre: Technology & Engineering
ISBN: 3527615083

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Research on metal-containing liquid crystals is a rapidly expanding, multidisciplinary field with new materials continually being synthesized and novel applications being developed. 'Metallomesogens' is the first comprehensive survey of the field, introducing the reader to: * materials design * synthesis * physical properties * emerging applications Carefully selected references round off this well-organized compendium. It is an indispensable guide to experienced researchers in coordination and organometallic chemistry as well as in liquid-crystal and materials science. Newcomers and graduate students will also benefit from this didactically sound introduction to the field.


Handbook of Heterocyclic Chemistry

Handbook of Heterocyclic Chemistry
Author: Alan R. Katritzky
Publisher: Elsevier
Total Pages: 568
Release: 2017-01-31
Genre: Science
ISBN: 1483293424

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Provides a one-volume overall picture of the largest of the classical divisions of organic chemistry, suitable for the graduate or advanced undergraduate student, as well as for research workers, both specialists in the field and those engaged in another discipline and requiring knowledge of heterocyclic chemistry. It represents Volume 9 of Comprehensive Heterocyclic Chemistry and utilizes the general chapters which appear in the 8-volume work. The highly systematic coverage given to the subject makes this the most authoritative one-volume account of modern heterocyclic chemistry available.