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| Author | : Yashwant V Pathak |
| Publisher | : Springer |
| Total Pages | : 499 |
| Release | : 2019-03-11 |
| Genre | : Medical |
| ISBN | : 3030061159 |
Download Surface Modification of Nanoparticles for Targeted Drug Delivery Book in PDF, ePub and Kindle
This unique book is the only one to discuss various new techniques developed to enhance the application of nanoparticulate drug delivery systems using surface modification of nanoparticles. The understanding of the surface characteristics nano-particles is growing significantly with the advent of new analytical techniques. Polymer chemistry is contributing to the development of many new versatile polymers which have abilities to accommodate many different, very reactive chemical groups, and can be used as a diagnostic tool, for better targeting, for more effective therapeutic results as well as for reducing the toxic and side effects of the drugs. Surface modification of such polymeric nanoparticles has been found by many scientists to enhance the application of nanoparticles and also allows the nano particles to carry specific drug molecule and disease /tumor specific antibodies which refine and improve drug delivery. Surface Modification of Nanoparticles for Targeted Drug Delivery is a collection essential information with various applications of surface modification of nanoparticles and their disease specific applications for therapeutic purposes.
| Author | : Jingyan Li |
| Publisher | : |
| Total Pages | : |
| Release | : 2012 |
| Genre | : |
| ISBN | : |
Download Surface-modified PLGA Nanoparticles for Targeted Drug Delivery to Neurons Book in PDF, ePub and Kindle
| Author | : Marie-Isabelle Baraton |
| Publisher | : |
| Total Pages | : 340 |
| Release | : 2003 |
| Genre | : Science |
| ISBN | : |
Download Synthesis, Functionalization and Surface Treatment of Nanoparticles Book in PDF, ePub and Kindle
Synthesis, Functionalization and Surface Treatment of Nanoparticles is an area of crucial importance in the emerging field of nanotechnology. Controlling the surface chemical composition and mastering its modification at the nanometer scale are critical issues for high-added value applications involving nanoparticles. The basic applications of surface functionalization range from altering the wetting or adhesion characteristics and improving the nanoparticles dispersion in matrices to enhancing the catalytic properties and ordering the interfacial region, and such. The creation of specific surface sites on nanoparticles for selective molecular attachment is considered a promising approach for their applications in nanofabrication, nanopatterning, selfassembly, nanosensors, bioprobes, drug delivery, pigments, photocatalysis, LEDs, etc. This book presents novel and improved synthesis methods and approaches for controlling and functionalizing the nanoparticle surfaces to enhance the overall performance of the nanoparticles for targeted applications.
| Author | : Mansoor M. Amiji |
| Publisher | : CRC Press |
| Total Pages | : 840 |
| Release | : 2006-12-19 |
| Genre | : Medical |
| ISBN | : 1420006630 |
Download Nanotechnology for Cancer Therapy Book in PDF, ePub and Kindle
While simultaneous breakthroughs occurring in molecular biology and nanoscience/technology will ultimately revolutionize all of medicine, it is with our efforts to prevent, diagnose, and treat cancer that many of the most dramatic advances will occur. In support of this potential, the U.S. National Cancer Institute (NCI) established the Alliance fo
| Author | : Deepak Thassu |
| Publisher | : CRC Press |
| Total Pages | : 373 |
| Release | : 2007-03-30 |
| Genre | : Medical |
| ISBN | : 1420008447 |
Download Nanoparticulate Drug Delivery Systems Book in PDF, ePub and Kindle
With the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. Nanoparticulate Drug Delivery Systems addresses the scientific methodologies, formulation, processing, applications, recent trends, and e
| Author | : Amit Kulkarni |
| Publisher | : |
| Total Pages | : 67 |
| Release | : 2009 |
| Genre | : |
| ISBN | : |
Download Surface Modification of Caboxyl-functionalized Polymeric Nanoparticles for Attachment of Targeting Peptides Book in PDF, ePub and Kindle
Cellular targeting of drug delivery systems represents a promising approach to reduce adverse effects by limiting release of pharmacological agent to desired target site. Controlled surface modification of nanoparticles by specific ligands can facilitate maximum receptor binding and cellular internalization, thereby increasing efficacy of targeting. This research attempts to establish the foundation for ligand-mediated, covalent surface modification of prefabricated carboxyl functionalized polymeric nanoparticles. Control over size and surface charges affecting stability is demonstrated through fabrication of particles in the absence and presence of a stabilizer. Covalent conjugation chemistry for amidation of surface carboxyl groups to amine-bearing ligands is explored and challenges in separating unbound ligands without compromising particle stability are presented. Successful synthesis and purification of a transcytosis-facilitating peptide sequence ( -RYRGDLGRR- ) and its analogues are outlined. Lastly, increased transport of peptide-modified nanoparticles across BeWo cell monolayers, an in vitro model of the human placenta is demonstrated. Preliminary competition studies showing this increased transport of peptide-functionalized particles to be a result of receptor mediated interactions are put forth. In summary, we provide sufficient experimental evidence to suggest increased transport properties of modified particles to be dependent on covalent surface conjugation of appropriate ligands. This establishes the foundation to evaluate controlled expression of targeting ligands for optimizing targeting efficiency of delivery systems.
| Author | : K. S. Joshy |
| Publisher | : Springer Nature |
| Total Pages | : 214 |
| Release | : 2021-06-21 |
| Genre | : Technology & Engineering |
| ISBN | : 9811621195 |
Download Nanoparticles for Drug Delivery Book in PDF, ePub and Kindle
This book introduces the reader to drug delivery with specific emphasis on the use of nanoparticles. It covers properties, characterization, and preparation of different types of nanoparticles and discusses recent advances in their structural design and biomedical application, as well as the issues and challenges associated with their design and use. Some of the topics covered include the potential application of nanoparticles in biomedical fields, hazards associated with use of nanoparticles for drug delivery, size-dependent factors in drug delivery applications, different organic, inorganic and their hybrid systems used in drug delivery, etc. It also highlights use of nanoparticles in controlled and targeted drug delivery, and their application in stimuli-responsive, especially pH-responsive, drug release. Additionally, it also focuses on biomimetic nanoparticles, challenges faced in the designing of nanoparticles for drug delivery in cancer, viral and bacterial diseases. The contents of this volume will be useful to researchers and professionals working on advances in targeted drug delivery systems.
| Author | : Yılmaz Çapan |
| Publisher | : CRC Press |
| Total Pages | : 654 |
| Release | : 2021-11-30 |
| Genre | : Medical |
| ISBN | : 1000375307 |
Download Drug Delivery with Targeted Nanoparticles Book in PDF, ePub and Kindle
Nanotechnology has the potential to change every part of our lives. Today, nanotechnology-based products are used in many areas, and one of the most important areas is drug delivery. Nanoparticulate drug delivery systems not only provide controlled delivery of drugs and improved drug solubility but also improve drug efficiency and reduce side effects via targeting mechanisms. However, compared with conventional drug delivery systems, few nanoparticle-based products are on the market and almost all are nontargeted or only passively targeted systems. In addition, obtaining targeted nanoparticle systems is quite complex and requires several evaluation mechanisms. This book discusses the production, characterization, regulation, and currently marketed targeted nanoparticle systems in a broad framework. It provides an overview of targeted nanoparticles’ (i) in vitro characterization, such as particle size, stability, ligand density, and type; (ii) in vivo behavior for different targeting areas, such as tumor, brain, and vagina; and (iii) current advances in this field, including clinical trials and regulation processes.
| Author | : Sudesh Kumar Yadav |
| Publisher | : Springer |
| Total Pages | : 186 |
| Release | : 2016-06-04 |
| Genre | : Medical |
| ISBN | : 9811008183 |
Download Nanoscale Materials in Targeted Drug Delivery, Theragnosis and Tissue Regeneration Book in PDF, ePub and Kindle
This book is the first of its kind to offer a comprehensive and up-to-date discussion of the use of nanoscale materials for biomedical applications, with a particular focus on drug delivery, theragnosis and tissue regeneration. It also describes in detail the methods used in the preparation of nanoparticles. Response of nanoparticles in biological systems are also explored. Nanotechnology has led to the advent of a new field, nanomedicine, which focuses on the use of nanomaterials as drug-delivery vehicles to develop highly selective and effective drugs. The combination of molecular imaging and nanotechnology has produced theragnostic nanoparticles, which allow the simultaneous detection and monitoring of diseases. Nanotechnology can also be combined with biomaterials to create scaffolds for tissue regeneration. Further, significant advances have been made in the areas of drug delivery, theragnostic nanoparticles and tissue regeneration materials. Some nanomedicines and tissue regeneration materials are already commercially available, while others are undergoing clinical trials, and promising results have been documented. Despite the rapid advances in nanomedicine, there is a relative dearth of literature on the biomedical applications of nanoscale materials.
| Author | : Hala Gali-Muhtasib |
| Publisher | : CRC Press |
| Total Pages | : 342 |
| Release | : 2020-02-19 |
| Genre | : Medical |
| ISBN | : 1000680878 |
Download Nanoparticle Drug Delivery Systems for Cancer Treatment Book in PDF, ePub and Kindle
In recent years, nanoparticles—bionanomaterials with specific physicochemical properties—have gained a great deal of scientific interest owing to their unique structure. Nanoparticle-based drugs are now widely regarded as a safer, more precise, and more effective mode of cancer therapy, considering their ability to enhance drug bioavailability, improve site-specific drug delivery, and protect nontarget tissues from toxic therapeutic drugs. This book compiles and details cutting-edge research in nanomedicine from an interdisciplinary team of international cancer researchers who are currently revolutionizing drug delivery techniques through the development of nanomedicines and nanotheranostics. Edited by Hala Gali-Muhtasib and Racha Chouaib, two prominent cancer researchers, this book will appeal to anyone involved in nanotechnology, cancer therapy, or drug delivery research.
