Studies Of Some Platinum Ii Complexes By Nmr PDF Download
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Author | : Joyce Margaret Edward |
Publisher | : |
Total Pages | : |
Release | : 1976 |
Genre | : Complex compounds |
ISBN | : |
Download Studies of Some Platinum II Complexes by N.M.R. Book in PDF, ePub and Kindle
Summary; This thesis describes the studies by NMR spectroscopy of a series of bis-(triethyl phosphine) complexes of platinum. ...
Author | : Joyce Margaret Edward |
Publisher | : |
Total Pages | : 0 |
Release | : 1976 |
Genre | : Complex compounds |
ISBN | : |
Download Studies of Some Platinum II Complexes by N.M.R. Book in PDF, ePub and Kindle
Summary; This thesis describes the studies by NMR spectroscopy of a series of bis-(triethyl phosphine) complexes of platinum. ...
Author | : Patricia Aileen Cronin |
Publisher | : |
Total Pages | : 450 |
Release | : 1966 |
Genre | : Nuclear magnetic resonance |
ISBN | : |
Download NMR and Kinetic Studies of Platinum (II) Complexes Book in PDF, ePub and Kindle
Author | : Emi Miyoshi |
Publisher | : |
Total Pages | : |
Release | : 2008 |
Genre | : DNA-ligand interactions |
ISBN | : |
Download Platinum(II) Complexes Book in PDF, ePub and Kindle
Author | : Stephen B. Howell |
Publisher | : Springer Science & Business Media |
Total Pages | : 563 |
Release | : 1991 |
Genre | : Medical |
ISBN | : 030644027X |
Download Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy Book in PDF, ePub and Kindle
Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds. Inhibition of this repair system by combination chemotherapy with the excision repair inhibitors HU and Ara-C produces synergistic cell kills and increased levels and persistance of DNA interstrand crosslinks. The studies with cis-DDP and ~-DDP in combination with UV induced thymine dimers suggest that there may be competition for DNA repair enzymes between the dimer and the platinum lesion. Whether the competing lesion is an intrastrand crosslink, interstrand crosslink, or platinum monoadduct (or all of these lesions) cannot be determined. The similarity between an intrastrand crosslink and a cyclobutane dimer suggests that these lesions may compete for repair. However, the increased peak levels of interstrand crosslinks, and increased persistence of these lesions at later time points suggest that this lesion may also be a substrate for the repair system. These observations may be of clinical relevance. Recently Dr. Kathy Albain of our institution has completed a Phase III I study using a 12 hour pretreatment with HU and Ara-C in patients prior to their cis-DDP therapy. She observed a significant number of responders in this trial (54). She is currently completing a second Phase IIII study substituting IV HU for the oral formulation. We anticipate initiating other clinical trials based upon these observations.
Author | : Catherine T. Hunt |
Publisher | : |
Total Pages | : 380 |
Release | : 1981 |
Genre | : Nuclear magnetic resonance spectroscopy |
ISBN | : |
Download Proton and Phosphorus-31 NMR Studies of Tertiary Phosphine Complexes of Palladium and Platinum Book in PDF, ePub and Kindle
Author | : Lori L. Bennett Slavin |
Publisher | : |
Total Pages | : 542 |
Release | : 1992 |
Genre | : Nuclear magnetic resonance spectroscopy |
ISBN | : |
Download Multinuclear NMR Studies of Platinum (II) Nucleotides Book in PDF, ePub and Kindle
Author | : Stephen Frederick Ralph |
Publisher | : |
Total Pages | : 632 |
Release | : 1987 |
Genre | : Platinum compounds |
ISBN | : |
Download 15N and 195Pt NMR Studies of Platinum Ammine Complexes Book in PDF, ePub and Kindle
Author | : Henry Alexander Raethel |
Publisher | : |
Total Pages | : 380 |
Release | : 1969 |
Genre | : Complex compounds |
ISBN | : |
Download Synthetic and Kinetic Studies of Some Platinum (II) Complexes Book in PDF, ePub and Kindle
Author | : |
Publisher | : |
Total Pages | : 219 |
Release | : 1990 |
Genre | : |
ISBN | : |
Download Platinum(II) Complexes as Spectroscopic Probes for Biomolecules Book in PDF, ePub and Kindle
The use of platinum(II) complexes as tags and probes for biomolecules is indeed advantageous for their reactivities can be selective for certain purposes through an interplay of mild reaction conditions and of the ligands bound to the platinum. The use of 195Pt NMR as a method of detecting platinum and its interactions with biomolecules was carried out with the simplest model of platinum(II) tagging to proteins. Variable-temperature 195Pt NMR spectroscopy proved useful in studying the stereodynamics of complex thioethers like methionine. The complex, Pt(trpy)Cl, with its chromophore has a greater potential for probing proteins. It is a noninvasive and selective tag for histidine and cysteine residues on the surface of cytochrome c at pH 5. The protein derivatives obtained are separable, and the tags are easily quantitated and differentiated through the metal-to-ligand charge transfer bands which are sensitive to the environment of the tag. Increasing the pH to 7.0 led to the modification by Pt(trpy)Clof Arg 91 in cytochrome c. Further studies with guanidine-containing ligands as models for arginine modification by Pt(trpy)Cl+ showed that guanidine can act as a terminal ligand and as a bridging ligand. Owing to the potential utility of Pt(trpy)L{sup n+} as electron dense probes of nucleic acid structure, interactions of this bis-Pt(trpy){sup 2+} complex with nucleic acids was evaluated. Indeed, the complex interacts non-covalently with nucleic acids. Its interactions with DNA are not exactly the same as those of its precedents. Most striking is its ability to form highly immobile bands of DNA upon gel electrophoresis. 232 refs.