Sensitivity Studies Of The Neutronic Design Of A Fission Converter Based Ephithermal Beam For Boron Neutron Capture Therapy PDF Download
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Author | : Shuichi Sakamoto |
Publisher | : |
Total Pages | : 246 |
Release | : 1997 |
Genre | : |
ISBN | : |
Download Sensitivity Studies of the Neutronic Design of a Fission Converter-based Ephithermal Beam for Boron Neutron Capture Therapy Book in PDF, ePub and Kindle
Author | : M. Frederick Hawthorne |
Publisher | : Springer |
Total Pages | : 1389 |
Release | : 2013-11-11 |
Genre | : Medical |
ISBN | : 1461512859 |
Download Frontiers in Neutron Capture Therapy Book in PDF, ePub and Kindle
Frontiers in Neutron Capture Therapy contains current research results originally presented at the Eighth International Symposium on Neutron Capture Therapy for Cancer in La Jolla, CA. This comprehensive collection of peer-reviewed manuscripts is showcased in two volumes covering all aspects of the development of this multidisciplinary approach to cancer therapy. Volume I of this work includes clinical results and current progress in treatment planning, neutron sources and dosimetry, while Volume II presents the synthesis, pharmacology and tissue-targeting design of boron compounds, including work on preclinical dosimetry and radiobiology. Intended for researchers and clinicians involved with or interested in new modes of cancer therapy, this volume will also serve as a useful guideline for scientists, students, and practitioners in the field.
Author | : Balendra Sutharshan |
Publisher | : |
Total Pages | : 340 |
Release | : 1998 |
Genre | : |
ISBN | : |
Download Engineering Design of a Fission Converter-based Epithermal Beam for Neutron Capture Therapy Book in PDF, ePub and Kindle
Author | : Wolfgang A.G. Sauerwein |
Publisher | : Springer Science & Business Media |
Total Pages | : 545 |
Release | : 2012-11-05 |
Genre | : Medical |
ISBN | : 3642313345 |
Download Neutron Capture Therapy Book in PDF, ePub and Kindle
Neutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter, which in principle allows for tumor cell-selective high-LET particle radiotherapy. This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.
Author | : Otto K. Harling |
Publisher | : Springer Science & Business Media |
Total Pages | : 340 |
Release | : 2013-03-08 |
Genre | : Medical |
ISBN | : 1468458027 |
Download Neutron Beam Design, Development, and Performance for Neutron Capture Therapy Book in PDF, ePub and Kindle
For this Workshop, the organizers have attempted to invite experts from all known centers which are engaged in neutron beam development for neutron capture therapy. The Workshop was designed around a series of nineteen invited papers which dealt with neutron source design and development and beam characterization and performance. Emphasis was placed on epithermal beams because they offer clinical advantages and are more challenging to implement than thermal beams. Fission reactor sources were the basis for the majority of the papers; however three papers dealt with accelerator neutron sources. An additional three invited papers provided a summary of clinical results of Ncr therapy in Japan between 1968 and 1989 and overviews of clinical considerations for neutron capture therapy and of the status of tumor targeting chemical agents for Ncr. Five contributed poster papers dealing with NCT beam design and performance were also presented. A rapporteurs' paper was prepared after the Workshop to attempt to summarize the major aspects, issues, and conclusions which resulted from this Workshop. Many people contributed to both the smooth functioning of the Workshop and to the preparation of these proceedings. Special thanks are reserved for Ms. Dorothy K.
Author | : Michael John Wilson |
Publisher | : |
Total Pages | : 63 |
Release | : 1991 |
Genre | : |
ISBN | : |
Download A Design of a Californium-based Epithermal Neutron Beam for Boron Neutron Capture Therapy Book in PDF, ePub and Kindle
Author | : |
Publisher | : |
Total Pages | : |
Release | : 1982 |
Genre | : |
ISBN | : |
Download קונטרס בהלכות שבת Book in PDF, ePub and Kindle
Author | : Kent Jason Riley |
Publisher | : |
Total Pages | : 710 |
Release | : 2001 |
Genre | : |
ISBN | : |
Download Construction and Characterization of a Fission Converter Based Epithermal Neutron Beam for BNCT Book in PDF, ePub and Kindle
(Cont.) Beam delivery is controlled with three in-line shutters that allow unrestricted access to the medical room while the reactor is at full power. Patient irradiations are controlled by redundant programmable logic controllers that automatically close the beam shutters when the prescribed monitor counts have been accumulated. Measurements were performed on central axis to assess beam performance. An in-air epithermal neutron flux of 8.4 +/- 0.8 E+09 n/cm2s was obtained with concomitant fast neutron and photon absorbed dose rates of 3.9 +/- 0.5 and 11.8 +/- 0.8 cGy/min. Depth dose profiles measured in-phantom are in general agreement with those determined from Monte Carlo calculations and indicate that normal tissue tolerance can be reached in treatment times of less than 10 minutes. The in-beam fast neutron and photon contaminants account for less than 10% of the dose received by normal tissue surrounding the target volume, which approaches the clinical optimum.
Author | : Rajat Kudchadker |
Publisher | : |
Total Pages | : 418 |
Release | : 1996 |
Genre | : Boron-neutron capture therapy |
ISBN | : |
Download Optimized Accelerator Based Epithermal Neutron Beams for Boron Neutron Capture Therapy Book in PDF, ePub and Kindle
Boron Neutron capture therapy (BNCT) is a form of radiation therapy in which nuclides having a high tendency for capturing thermal neutrons, react by emitting charged particles of short range and leaving essentially no residual radioactivity. If these capture nuclides are selectively introduced into the tumor cells, it is theoretically possible to destroy only the tumor and in the process spare the neighboring healthy tissue. Currently, reactors are the only known source of neutrons being used for BNCT. A number of studies have been done using Monte Carlo computer codes such as MCNP to determine an optimum design of a moderator reflector configuration for an accelerator based neutron source utilizing the Li-7(p, n)Be-7 reaction. To confirm this, benchmark experiments were conducted using both a 2.0 MeV Radio Frequency Quadrupole (RFQ) accelerator and a 2.0 MeV Van de Graaff generator. All previous studies had concluded that 2.5 MeV protons would be optimum, which produces neutron having a maximum energy of 787 keV. For BNCT the desired neutron energies are between 1 eV and nominally 10 keV, i.e. in the epithermal region. These neutrons must hence be moderated to bring them down to the desired energy range. The moderator-reflector assemblies for reactor neutrons or those from 2.5 MeV protons on lithium require a little less than a meter of material to achieve the desired neutron spectrum. This research work focuses on using protons with energies just above the Li-7(p, n)Be-7 reaction threshold. These lower energy protons produce neutrons with a maximum energy of just a few hundred keV requiring much less moderation as compared to the 2.5 MeV proton lithium source. The penalty for the low energy neutron spectrum is the low yield of neutrons per proton as compared to the 2.5 MeV protons on lithium. But, less moderation implies that the patient can be moved closer to the lithium target (neutron source), thus making a more efficient use of the source neutrons. This would partially or wholly compensate for the lower yield per proton. In addition the smaller moderator-reflector assembly would result in less scattering occurring, thereby not degrading the forward directional quality of the beam as much as in current assemblies designed for use with the 2.5 MeV protons on a lithium target.
Author | : Ronald Daniel Rogus |
Publisher | : |
Total Pages | : 1266 |
Release | : 1994 |
Genre | : |
ISBN | : |
Download Design and Dosimetry of Epithermal Neutron Beams for Clinical Trials of Boron Neutron Capture Therapy at the MITR-II Reactor Book in PDF, ePub and Kindle