Resources For Precision Analysis Of Human Breast Cancer PDF Download

The past decade has seen dramatic progress in our understanding of the basic cell and molecular biology of breast cancer. However, the translation of this basic science knowledge and ideas has been impeded by the limited numbers of clinician-scientists with skills to effectively collaborate with basic scientists and to accurately interpret tissue pathology, quality and the cellular composition of heterogeneous tissue samples subjected to molecular study. Beyond this there is the problem of access to appropriate human tissue samples. The Pi's overall goal is the improvement in our current ability to predict individual risk of development of invasive disease and to predict further progression of invasive disease in terms of resistance to therapies. The specific aims of the PI are (1) continue to advance the two general avenues of research that are currently ongoing in the laboratory and which have direct relevance to important clinical problems in the management of early pre-invasive disease and the therapy of later advanced disease, (2) continue to direct the Manitoba Breast Tumor Bank and offer clinical pathology expertise and advice to many investigators who seek access to appropriate tissues to test their ideas, and (3) to work with others to develop and analyze new tissue resources such as those based on collection of pre-invasive lesions and tissue samples and collection of tumor samples associated with clinical trials.