Receptor Tyrosine Kinase Specificity In Mediating Migration And Induction Of Matrix Metalloprotease Mmp 9 In Keratinocyte And Squamous Cell Carcinoma PDF Download

Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Receptor Tyrosine Kinase Specificity In Mediating Migration And Induction Of Matrix Metalloprotease Mmp 9 In Keratinocyte And Squamous Cell Carcinoma PDF full book. Access full book title Receptor Tyrosine Kinase Specificity In Mediating Migration And Induction Of Matrix Metalloprotease Mmp 9 In Keratinocyte And Squamous Cell Carcinoma.

Receptor Tyrosine Kinase Specificity in Mediating Migration and Induction of Matrix Metalloprotease (MMP)-9 in Keratinocyte and Squamous Cell Carcinoma

Receptor Tyrosine Kinase Specificity in Mediating Migration and Induction of Matrix Metalloprotease (MMP)-9 in Keratinocyte and Squamous Cell Carcinoma
Author: Lisa Joy McCawley
Publisher:
Total Pages: 368
Release: 1998
Genre:
ISBN:
GET BOOK

Download Receptor Tyrosine Kinase Specificity in Mediating Migration and Induction of Matrix Metalloprotease (MMP)-9 in Keratinocyte and Squamous Cell Carcinoma Book in PDF, ePub and Kindle

Cellular migration is an integral component of normal physiological processes including embryogenesis, angiogenesis, and wound healing. Aberrations in existing mechanisms which dictate epithelial migration can lead to pathological conditions such as tumor metastasis. Receptor tyrosine kinases regulate a many of the cellular events necessary in the development of a migratory phenotype including cell junction dissolution, cell locomotion and matrix remodeling; however, the functional consequences of receptor tyrosine kinase activation display receptor type and cell type specificity. The work described in this thesis addresses selectivity of receptor tyrosine action at several crucial stages required for cell motility and invasion. My research supports a role for selective induction of matrix metalloprotease (MMP)-9 by motogenic receptor tyrosine kinases, and demonstrates that activity of this protease is required during the course of keratinocyte migration, in addition, these studies suggest that duration of MAPK activation is a basis of discrimination between the motogenic and non-motogenic actions of various receptor tyrosine kinases. In this manner, prolonged activation of signaling components provides a mechanism to modulate gene products, such as MMP-9, required during migration, and thus represents an underlying biochemical mechanism for receptor tyrosine kinase specificity in the generation of a migratory phenotype.

Highlights in Skin Cancer

Highlights in Skin Cancer
Author: Pierre Vereecken
Publisher:
Total Pages: 310
Release: 2013
Genre:
ISBN: 9789535171324
GET BOOK

Download Highlights in Skin Cancer Book in PDF, ePub and Kindle

Highlights in Skincancer is a companion handbook published expressly for all the practitionners who are interested in skin cancers: medical oncologists and dermatologists but also residents, general practitionners, surgeons, plastic surgeons. The book is designed to teach new aspects of skincancers in the context of practical clinical settings. Each topic is an expert view of a specific skincancer field. Highlights in Skincancer provides information on a wide range of skincancer topics with emphasis on the emergence of new diagnostic approaches, therapeutic perspectives, and a better insight into the biology of the skin tumours. No doubt that the Highlights in Skincancer will be considered as a real tool throughout a medical career.

Chemical Abstracts

Chemical Abstracts
Author:
Publisher:
Total Pages: 2540
Release: 2002
Genre: Chemistry
ISBN:
GET BOOK

Download Chemical Abstracts Book in PDF, ePub and Kindle

Wound Healing

Wound Healing
Author: Vlad Alexandrescu
Publisher: BoD – Books on Demand
Total Pages: 546
Release: 2016-10-12
Genre: Medical
ISBN: 9535126784
GET BOOK

Download Wound Healing Book in PDF, ePub and Kindle

Outstanding scientific advances over the last decades unceasingly reveal real complexity of wound-healing process, astonishing in its staged progression, as life is unfolding itself. This natural course of tissue repair seems to bear thousands of overlapping molecular and macroscopic processes that nowadays only start to unfold to our knowledge. The present volume collecting recent scientific references proposes to readers a two-folded audacious goal. First, an updated design of intimate cellular mechanisms is entailed in tissue regeneration that emanates from the first section of the book. Next, a multidisciplinary therapeutic perspective that focuses on macroscopic healing throughout the second part of this work adds clinically integrated observation. Practical diagnostic and treatment information is appended in each chapter that may equally help experienced clinicians or dedicated students and researchers in broadening essential breaking points of their work. It is the wish of all multidisciplinary experts who gather prominent author's panel of this volume to incorporate latest medical reports and compel limits of current understanding for better tissue regeneration, limb salvage, and improved quality of life of our patients.

Heparanase

Heparanase
Author: Israel Vlodavsky
Publisher: Springer Nature
Total Pages: 871
Release: 2020-04-09
Genre: Medical
ISBN: 3030345211
GET BOOK

Download Heparanase Book in PDF, ePub and Kindle

Written by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.

Human Skin Cancers

Human Skin Cancers
Author: Miroslav Blumenberg
Publisher: BoD – Books on Demand
Total Pages: 214
Release: 2018-05-02
Genre: Medical
ISBN: 1789230942
GET BOOK

Download Human Skin Cancers Book in PDF, ePub and Kindle

Human skin cancers, the most common type of tumors, represent a significant health burden. The deadliest is unquestionably melanoma. Half of melanomas have an activating mutation in the BRAF gene, prompting development of novel drugs, vemurafenib and dabrafenib, specifically targeting mutated BRAF. Trametinib and cobimetinib, which block MEK, a BRAF effector protein, have been used in combination with BRAF inhibitors. A promising new melanoma treatment is immunotherapy, approach that boosts patient's own immune system to attack cancer. Pembrolizumab and nivolumab inhibit PD-1, whereas Ipilimumab targets CTLA-4, another immunity check point, to boost the immune response. Here we focus on pathways, mechanisms, targets and treatments of human skin cancers, with particular emphasis on the new developments in the research on melanomas.

Matrix Metalloproteinases and TIMPs

Matrix Metalloproteinases and TIMPs
Author: J. F. Woessner
Publisher: Oxford University Press on Demand
Total Pages: 223
Release: 2000
Genre: Medical
ISBN: 9780198502685
GET BOOK

Download Matrix Metalloproteinases and TIMPs Book in PDF, ePub and Kindle

The matrix metalloproteinases (MMPs) are a large family of enzymes that breakdown different components of the extracellular matrix. Their catalytic activity is dependent a metal ion, usually zinc. This issue of the Protein Profiles covers the sequence information, three-dimensional structures, activation, protein substrates, specificity requirements, inhibition, and biological roles of all the currently identified MMPs. The action of these enzymes must be carefully regulated. One way the cell does this, is by releasing inhibitory molecules known as tissue inhibitors of metalloproteinases (TIMPs). This volume contains information on the sequences, three-dimensional structures, and biological roles of the 4 known classes of TIMP. Matrix metalloproteinases will therefore be an invaluable source of data for all researchers interested in MMPs and TIMPs.

Textbook of Aging Skin

Textbook of Aging Skin
Author: Miranda A. Farage
Publisher: Springer Science & Business Media
Total Pages: 1255
Release: 2009-12-02
Genre: Medical
ISBN: 3540896554
GET BOOK

Download Textbook of Aging Skin Book in PDF, ePub and Kindle

This comprehensive ‘Major Reference Book’ compiles all current and latest information on aging skin in a two-volume set. Highly structured with a reader-friendly format, it covers a wide range of areas such as basic sciences, the different diseases and conditions which occur with aging (from malignant to non-malignant), the latest techniques and methods being used such as bioengineering methods and biometrics as well as toxicological and safety considerations for the elderly population. It also illustrates the global consumers’ sociological and psychological implications, ethnicity and gender differences and includes marketing considerations for this elderly group. This unique and comprehensive guide will become the main reference textbook on this topic.

Cell Surface Proteases

Cell Surface Proteases
Author:
Publisher: Elsevier
Total Pages: 475
Release: 2003-05-03
Genre: Science
ISBN: 0080490883
GET BOOK

Download Cell Surface Proteases Book in PDF, ePub and Kindle

Cell Surface Proteases provides a comprehensive overview of these important enzymes that catalyze the hydrolysis of a protein as it degrades to a simpler substance. In the 1990s, an explosion of new discoveries shed light on the role of cell surface proteases and extended it beyond degradation of extracellular matrix components to include its influence on growth factors, cell signaling, and other cellular events. This volume unites the scientific literature from across disciplines and teases out unified themes of interactions between cell surface proteases and interconnecting cell surface-related systems -- including integrins and other adhesion molecules. Scientists and students involved in developmental biology, cell biology and disease processes will find this an indispensable resource. * Provides an overview of the entire field of cell surface proteases in a single volume* Presents major issues and astonishing discoveries at the forefront of modern developmental biology and developmental medicine * A thematic volume in the longest-running forum for contemporary issues in developmental biology with over 30 years of coverage