Receptor-Receptor Interactions
Author | : Kjell Fuxe |
Publisher | : Springer Science & Business Media |
Total Pages | : 577 |
Release | : 2013-03-13 |
Genre | : Computers |
ISBN | : 1468454153 |
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Author | : Kjell Fuxe |
Publisher | : Springer Science & Business Media |
Total Pages | : 577 |
Release | : 2013-03-13 |
Genre | : Computers |
ISBN | : 1468454153 |
Author | : Kjell Fuxe |
Publisher | : Springer |
Total Pages | : 577 |
Release | : 2015-12-30 |
Genre | : Science |
ISBN | : 1349089494 |
Author | : Frederick J Ehlert |
Publisher | : World Scientific |
Total Pages | : 750 |
Release | : 2014-11-13 |
Genre | : Medical |
ISBN | : 9814632163 |
The interaction of a drug with a receptor generates a code of information having components of affinity and efficacy. How this information is translated into a response depends on the unique cells, tissue, organ or system in which the receptor resides. This book describes how to analyze various responses to estimate the affinity and efficacy components of the initial drug-receptor interaction. More specifically, it describes how to measure the affinity and efficacy of drugs through the analysis of single receptor activity, the activation state of a population of receptors, and responses downstream from receptor activation. More light is thrown on ligand-gated ion channels and G protein-coupled receptors in this book.The topics discussed include radioligand binding, estimation of agonist affinity and efficacy, competitive antagonism, inverse agonism, allosteric agonists and modulators, agonist bias, modulation of pathway selectivity, and the estimation of ligand affinity for active and inactive receptor states. The natural history and structure of ligand-gated ion channels, G proteins, and G protein-coupled receptors are also discussed.
Author | : P. Michael Conn |
Publisher | : Academic Press |
Total Pages | : 539 |
Release | : 2013-10-18 |
Genre | : Science |
ISBN | : 0124104703 |
This new volume of Methods in Cell Biology looks at receptor-receptor interactions, with sections on allosteric and effector interactions, crystallization and modeling, measuring receptor-receptor interactions and oligomerization in individual classes. With cutting-edge material, this comprehensive collection is intended to guide researchers of receptor-receptor interactions for years to come. Covers sections on allosteric and effector interactions, crystallization and modeling, measuring receptor-receptor interactions and oligomerization in individual classes Chapters are written by experts in the field Cutting-edge material
Author | : Anthony P. Davenport |
Publisher | : Humana |
Total Pages | : 240 |
Release | : 2005-03-25 |
Genre | : Medical |
ISBN | : 9781588294203 |
A comprehensive collection of readily reproducible methods for studying receptors in silico, in vitro, and in vivo. These cutting-edge techniques cover mining from curated databases, identifying novel receptors by high throughput screening, molecular methods to identify mRNA encoding receptors, radioligand binding assays and their analysis, quantitative autoradiography, and imaging receptors by positron emission tomography (PET). Highlights include phenotypic characterization of receptors in knockout mice, imaging receptors using green fluorescent protein and fluorescent resonance energy transfer, and quantitative analysis of receptor mRNA by TaqMan PCR. These book equips the researcher with techniques for exploring the unprecedented number of new receptor systems now emerging and the so-called "orphan" receptors whose activating ligand has not been identified.
Author | : D. J. Triggle |
Publisher | : |
Total Pages | : 628 |
Release | : 1971 |
Genre | : Drug receptors |
ISBN | : |
Author | : John C. Foreman |
Publisher | : CRC Press |
Total Pages | : 314 |
Release | : 2010-09-10 |
Genre | : Medical |
ISBN | : 1420052551 |
For the past four decades, University College London has offered a renowned course on receptor pharmacology. Originating from this course, the perennially bestselling Textbook of Receptor Pharmacology has presented in-depth coverage of this rapidly expanding area of research. This third edition continues to combine current understanding of classica
Author | : Puneet Kumar |
Publisher | : Springer Nature |
Total Pages | : 729 |
Release | : 2020-10-29 |
Genre | : Medical |
ISBN | : 9811535566 |
Numerous phenomenal advances have been made towards understanding the role of neurotransmitters in the pathophysiology of neurological disorders, and these have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of such disorders. This book provides a comprehensive and detailed explanation of brain neurotransmitters and their receptors and associated channels. It includes a basic introduction, and also discusses the functions and recent advances and their pharmacology, highlighting the role of various computer aided drug design (CADD) strategies for the development of therapeutic ligands to modulate these receptors/ion channels. Written in an easy-to-read style, it is intended for neuroscience and pharmaceutical students and researchers working in the area of brain neurotransmitters.
Author | : Michael Denison |
Publisher | : CRC Press |
Total Pages | : 243 |
Release | : 1998-08-10 |
Genre | : Medical |
ISBN | : 9781560326335 |
Many of the toxic effects elicited by xenobiotics can be explained at the molecular level by their interaction with receptors or by disruption or interference with receptor-mediated signal transduction pathways. This volume describes molecular approaches and reviews of current research. It provides reviews of numerous research areas which are directly related to the analysis of the molecular mechanism by which xenobiotics modulate signal transduction and gene expression.
Author | : Terrence P. Kenakin |
Publisher | : Raven Press (ID) |
Total Pages | : 504 |
Release | : 1993 |
Genre | : Medical |
ISBN | : |
A guide to quantitative drug-receptor pharmacology, this new edition aims to cover all receptor systems, whether derived from molecular biology or animal studies. Using existing data, it demonstrates how theoretical models facilitate drug development, and integrates theory with practice. This second edition aims to be a valuable resource for all researchers involved in the drug design and development process. Not only has the text been updated and revised, but reflecting the significant technical breakthroughs of recent years, it now more generally encompasses all receptor systems, whether derived from molecular biology or whole animal studies. These systems are examined within the framework of current drug receptor theories, particularly the receptor occupation theory, the operational model of drug action and the ternary complex model.