Recent Progress In Toxicity And Drug Testing PDF Download
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Author | : Judith Baker |
Publisher | : |
Total Pages | : 0 |
Release | : 2015-02-13 |
Genre | : Drugs |
ISBN | : 9781632423511 |
Download Recent Progress in Toxicity and Drug Testing Book in PDF, ePub and Kindle
Present-day drug design and testing includes experimental in-vitro and in-vivo measurements of the drug candidate's adsorption, distribution, metabolism, elimination and toxicity (ADMET) properties in the initial stages of drug discovery. Just a poor percentage of the recommended drug candidates get the authorization of government and reach the market place. Disadvantageous pharmacokinetic properties, bad bioavailability and efficiency, negative side effects, poor solubility and toxicity matters are responsible for most of the drug failures confronted in the pharmaceutical industry. Authors from across the globe have provided information elucidating pharmaceutical concerns, regulatory policies and clinical properties in their respective countries hoping that the open trade of scientific ideas and outcomes compiled in this book will result in enhanced pharmaceutical products. This book has a section on drug design covering several research chapters.
Author | : Ali S. Faqi |
Publisher | : Academic Press |
Total Pages | : 904 |
Release | : 2012-11-02 |
Genre | : Business & Economics |
ISBN | : 0123878152 |
Download A Comprehensive Guide to Toxicology in Preclinical Drug Development Book in PDF, ePub and Kindle
A Comprehensive Guide to Toxicology in Preclinical Drug Development is designed for toxicologists who need a thorough understanding of the drug development process. This multi-contributed reference will provide a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics --
Author | : Sivakumar Joghi Thatha Gowder |
Publisher | : BoD – Books on Demand |
Total Pages | : 255 |
Release | : 2013-01-23 |
Genre | : Medical |
ISBN | : 9535109464 |
Download New Insights into Toxicity and Drug Testing Book in PDF, ePub and Kindle
This book "New Insights into Toxicity and Drug Testing" covers all emerging technologies (profiling technologies, 3D cultures, next generation sequencing etc.), available methods and models to evaluate candidate drugs and medicinal plants with reference to toxicity, drug testing and development. This book is an original contribution of experts from different parts of the globe and the in-depth information will be a significant resource for scientists and physicians who are directly dealing with drugs / medicines and human life.
Author | : Judith Baker |
Publisher | : |
Total Pages | : 0 |
Release | : 2015-01-17 |
Genre | : Drugs |
ISBN | : 9781632420374 |
Download Advances in Toxicity and Drug Testing Book in PDF, ePub and Kindle
This book discusses the latest advances and developments in toxicity and drug testing. It encompasses rising technologies (3D cultures, next generation sequencing, profiling technologies, etc.), available techniques and models to assess potential drugs and medicinal plants with reference to drug testing and advancement, and toxicity. Contributions have been made in this book by veterans from across the world. The aim of this book is to serve as a valuable source of information for physicians as well as scientists who are directly dealing with drugs/medicines and human life.
Author | : Ali S. Faqi |
Publisher | : Academic Press |
Total Pages | : 988 |
Release | : 2016-11-03 |
Genre | : Medical |
ISBN | : 0128036214 |
Download A Comprehensive Guide to Toxicology in Nonclinical Drug Development Book in PDF, ePub and Kindle
A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Second Edition, is a valuable reference designed to provide a complete understanding of all aspects of nonclinical toxicology in the development of small molecules and biologics. This updated edition has been reorganized and expanded to include important topics such as stem cells in nonclinical toxicology, inhalation and dermal toxicology, pitfalls in drug development, biomarkers in toxicology, and more. Thoroughly updated to reflect the latest scientific advances and with increased coverage of international regulatory guidelines, this second edition is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. Provides unique content that is not always covered together in one comprehensive resource, including chapters on stem cells, abuse liability, biomarkers, inhalation toxicology, biostatistics, and more Updated with the latest international guidelines for nonclinical toxicology in both small and large molecules Incorporates practical examples in order to illustrate day-to-day activities and the expectations associated with working in nonclinical toxicology
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 217 |
Release | : 2007-10-05 |
Genre | : Nature |
ISBN | : 0309109922 |
Download Toxicity Testing in the 21st Century Book in PDF, ePub and Kindle
Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.
Author | : Michael G. Bissell |
Publisher | : Elsevier Health Sciences |
Total Pages | : 216 |
Release | : 2012-09-28 |
Genre | : Medical |
ISBN | : 1455747874 |
Download Toxicology Testing, An Issue of Clinics in Laboratory Medicine Book in PDF, ePub and Kindle
This issue of Clinics in Laboratory Medicine, titled Toxicology Testing, includes the following topics; Progress in Clinical Toxicology Testing, The Prescription Drug Abuse Epidemic, Substance Abuse Among Healthcare Professionals, Pain Management Drug Testing, Ethanol Biomarkers, Newly-emerging Drugs of Abuse, Synthetic Cannabinoids, Synthetic Cathenones, Immunoassay Methodology in Drugs-of-abuse Testing, Toxicology Testing in Alternative Specimen Matrices, Principles and Procedures in Postmortem Toxicology, and Pharmacogenetics and the Future of Toxicology Testing. Advances in toxicology testing are paving the way for major improvements in the way scientists evaluate health risks posed by toxic chemicals. Toxicity tests help scientists better understand how the human body carries out normal functions that are key to maintaining health. Therefore, this topic is important to the field of Laboratory Medicine.
Author | : Institute of Medicine |
Publisher | : National Academies Press |
Total Pages | : 107 |
Release | : 2014-02-06 |
Genre | : Medical |
ISBN | : 0309292492 |
Download Improving and Accelerating Therapeutic Development for Nervous System Disorders Book in PDF, ePub and Kindle
Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.
Author | : H. Rašková |
Publisher | : Elsevier |
Total Pages | : 113 |
Release | : 2013-10-22 |
Genre | : Medical |
ISBN | : 1483157202 |
Download Mechanisms of Drug Toxicity Book in PDF, ePub and Kindle
Mechanisms of Drug Toxicity, Volume 4 presents the proceedings of the 3rd International Pharmacological Meeting held in Sao Paulo, Brazil in 1966. The book discusses the drug-induced pathobiotic effects; the mechanisms of adverse reactions; and enzyme induction in the mechanism of chronic toxicity. The text also describes the influence of inducing substances on the growth of liver and microsomal electron transport systems; the quantitative aspects of chronic toxicity; and the facts and fallacies in predicting drug effects in human.
Author | : Institute of Medicine |
Publisher | : National Academies Press |
Total Pages | : 442 |
Release | : 2011-04-03 |
Genre | : Medical |
ISBN | : 0309158060 |
Download Rare Diseases and Orphan Products Book in PDF, ePub and Kindle
Rare diseases collectively affect millions of Americans of all ages, but developing drugs and medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute of Medicine (IOM) recommends implementing an integrated national strategy to promote rare diseases research and product development.