Recent Advances in Myelin Plasticity
Author | : Domna Karagogeos |
Publisher | : Frontiers Media SA |
Total Pages | : 113 |
Release | : 2021-07-22 |
Genre | : Science |
ISBN | : 2889710734 |
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Author | : Domna Karagogeos |
Publisher | : Frontiers Media SA |
Total Pages | : 113 |
Release | : 2021-07-22 |
Genre | : Science |
ISBN | : 2889710734 |
Author | : Michael R. Kreutz |
Publisher | : Springer Science & Business Media |
Total Pages | : 611 |
Release | : 2012-02-18 |
Genre | : Medical |
ISBN | : 3709109310 |
This book introduces the current concepts of molecular mechanisms in synaptic plasticity and provides a comprehensive overview of cutting-edge research technology used to investigate the molecular dynamics of the synapses. It explores current concepts on activity-dependent remodeling of the synaptic cytoskeleton and presents the latest ideas on the different forms of plasticity in synapses and dendrites. Synaptic Plasticity in Health and Disease not only supplies readers with extensive knowledge on the latest developments in research, but also with important information on clinical and applied aspects. Changes in spine synapses in different brain disease states, so-called synaptopathies, are explained and described by experts in the field. By outlining basic research findings as well as physiological and pathophysiological impacts on synaptic plasticity, the book represents an essential state-of-the-art work for scientists in the fields of biochemistry, molecular biology and the neurosciences, as well as for doctors in neurology and psychiatry alike.
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 610 |
Release | : 2000-11-13 |
Genre | : Social Science |
ISBN | : 0309069882 |
How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.
Author | : Oscar Alzate |
Publisher | : CRC Press |
Total Pages | : 356 |
Release | : 2009-10-26 |
Genre | : Medical |
ISBN | : 1420076264 |
In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we beg
Author | : S.K. Malhotra |
Publisher | : Elsevier |
Total Pages | : 257 |
Release | : 1995-12-08 |
Genre | : Science |
ISBN | : 0080526403 |
Part of a series which aims to cover recent knowledge in the field of neural science, this volume discusses such topics as: the molecular bases of nerve regeneration; plasticity of descending spinal pathways in developing mammals; and development of the mammalian auditory hindbrain.
Author | : Christopher M. Filley |
Publisher | : Cambridge University Press |
Total Pages | : 231 |
Release | : 2016-04-28 |
Genre | : Medical |
ISBN | : 1107035414 |
Presenting the novel concept of white matter dementia, this unique book offers hope for a better understanding and treatment of dementia.
Author | : Institute of Medicine |
Publisher | : National Academies Press |
Total Pages | : 457 |
Release | : 2001-08-10 |
Genre | : Medical |
ISBN | : 0309072859 |
Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families.
Author | : Illana Gozes |
Publisher | : Academic Press |
Total Pages | : 344 |
Release | : 2016-12-30 |
Genre | : Psychology |
ISBN | : 0128037121 |
Neuroprotection in Alzheimer’s Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking skills, and eventually, even the ability to carry out the simplest tasks. It is characterized by death of synapses coupled to death nerve cells and brain degeneration which is manifested by loss of cognitive abilities. Understanding neuroprotection in Alzheimer’s disease will pave the path to better disease management and novel therapeutics. Comprehensive reference detailing neuroprotection in Alzheimer’s Disease, with details on nerve cell protection and new advances in disease management Combines the knowledge and points-of-view of both medical doctors and basic scientists, putting the subject at the forefront for further clinical development Edited by one of the leading researchers in Alzheimer’s Disease
Author | : Markus Kipp |
Publisher | : MDPI |
Total Pages | : 330 |
Release | : 2021-01-06 |
Genre | : Medical |
ISBN | : 3039436899 |
The adult vertebrate central nervous system mainly consists of neurons, astrocytes, microglia cells, and oligodendrocytes. Oligodendrocytes, the myelin-forming cells of the CNS, are subjected to cell stress and subsequent death in a number of metabolic or inflammatory disorders, among which multiple sclerosis (MS) is included. This disease is associated with the development of large demyelinated plaques, oligodendrocyte destruction, and axonal degeneration, paralleled by the activation of astrocytes and microglia as well as the recruitment of peripheral immune cells to the site of tissue injury. Of note, viable oligodendrocytes and an intact myelin sheath are indispensable for neuronal health. For example, it has been shown that oligodendrocytes provide nutritional support to neurons, fast axonal transport depends on proper oligodendrocyte function, and mice deficient in mature myelin proteins eventually display severe neurodegeneration. This Special Issue contains a collection of highly relevant primary research articles as well as review articles focusing on the development, physiology, and pathology of the oligodendrocyte–axon–myelin unit.
Author | : Catherine Belzung |
Publisher | : Springer Science & Business Media |
Total Pages | : 447 |
Release | : 2014-07-08 |
Genre | : Medical |
ISBN | : 364236232X |
This volume brings together authors working on a wide range of topics to provide an up to date account of the underlying mechanisms and functions of neurogenesis and synaptogenesis in the adult brain. With an increasing understanding of the role of neurogenesis and synaptogenesis it is possible to envisage improvements or novel treatments for a number of diseases and the possibility of harnessing these phenomena to reduce the impact of ageing and to provide mechanisms to repair the brain.