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Protective and Detrimental Role of Heme Oxygenase-1

Protective and Detrimental Role of Heme Oxygenase-1
Author: Valeria Sorrenti
Publisher: MDPI
Total Pages: 220
Release: 2019-11-14
Genre: Science
ISBN: 3039218069

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The book “Protective and Detrimental Role of Heme Oxygenase-1”, includes a selection of original research papers and reviews aimed at understanding the dual role (protective and detrimental) of HO-1 and the involved signaling pathways. Original research papers and reviews aimed at the identification of natural molecules or new synthetic compounds able to modulate HO-1 activity/expression help make HO-1 a potential therapeutic target for the amelioration of various diseases.


Protective and Detrimental Role of Heme Oxygenase-1

Protective and Detrimental Role of Heme Oxygenase-1
Author: Valeria Sorrenti
Publisher:
Total Pages: 220
Release: 2019
Genre: Medicine (General)
ISBN: 9783039218073

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The book “Protective and Detrimental Role of Heme Oxygenase-1”, includes a selection of original research papers and reviews aimed at understanding the dual role (protective and detrimental) of HO-1 and the involved signaling pathways. Original research papers and reviews aimed at the identification of natural molecules or new synthetic compounds able to modulate HO-1 activity/expression help make HO-1 a potential therapeutic target for the amelioration of various diseases.


Heme Oxygenase

Heme Oxygenase
Author: Leo E. Otterbein
Publisher: Nova Publishers
Total Pages: 442
Release: 2005
Genre: Medical
ISBN: 9781594544477

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Heme oxygenase is an enzyme which breaks down heme, the iron-containing oxygen-carrying constituent of the red blood cells. Heme must be synthesised and degraded within an individual nucleated cell, as heme is essential for the maintenance of cellular homeostasis by sensing or using oxygen. Physiological heme degradation is catalysed by the two functional isozymes of heme oxygenase, heme oxygenase-1 (HO-1) and HO-2, yielding CO, iron, and biliverdin IX N. Heme oxygenase-1 (HO-1), has potent anti-inflammatory, anti-oxidant and anti-proliferative effects, is up-regulated by multiple stimuli and provides protection against oxidative stress. HO-1 also plays an important role in the regulation of cardiovascular function and is involved in many other diseases such as sickle cell disease. This new book brings together leading research from around the world in this field.


Sustainable Agriculture in the Era of Climate Change

Sustainable Agriculture in the Era of Climate Change
Author: Rajib Roychowdhury
Publisher: Springer Nature
Total Pages: 696
Release: 2020-07-06
Genre: Science
ISBN: 3030456692

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Under ongoing climate changes, natural and cultivated habitats of major crops are being continuously disturbed. Such conditions impose and exacerbate abiotic and biotic stressors. Drought, salinity, flood, cold, heat, heavy metals, metalloids, oxidants, irradiation, etc. are important abiotic stressors, while diseases and infections caused by plant pathogens, such as fungal agents, bacteria and viruses, are major biotic stresses. In many instances, stresses have become the major limiting factor for agricultural productivity and exert detrimental role on growth and yield of the crops. To help feed an ever increasing world population and to ensure global food security, concerted efforts from scientists and researchers have identified strategies to manage and mitigate the impacts of climate-induced stresses. This book, summarizing their findings, is aimed at crop improvement beyond such kind of barriers, by agronomic practices (genetics, breeding, phenotyping, etc.) and biotechnological applications, including molecular markers, QTL mapping, genetic engineering, transgenesis, tissue culture, various 'omics' technologies and gene editing. It will cover a wide range of topics under environmental challenges, agronomy and agriculture processes, and biotechnological approaches. Additionally, fundamental mechanisms and applied information on stress responses and tolerance will be discussed. This book highlights problems and offers proper solutions for crop stress management with recent information and up-to-date citations. We believe this book is suitable for scientists, researchers and students working in the fields of agriculture, plant science, environmental biology and biotechnology.


Human Pathobiochemistry

Human Pathobiochemistry
Author: Toshitaka Oohashi
Publisher: Springer
Total Pages: 349
Release: 2019-03-13
Genre: Medical
ISBN: 981132977X

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This textbook uses a case-study approach to present the core principles of biochemistry and molecular biology in the context of human disease to students who will be involved in patient care. The 29 clinical cases have been carefully selected to cover key scientific concepts and some common, and other not so common, diseases. While the principal focus is on topics relating to metabolic disease, further subjects such as connective tissue disorders, neurological disorders, auto-inflammatory disorders, infective diseases, and cancer are also addressed. Each chapter provides a specific patient report that includes the natural history, pertinent clinical laboratory data, physical findings, subsequent diagnosis, and therapy. This is followed by a comprehensive discussion of the normal biochemical processes and reactions pertaining to the case, along with the pathophysiological mechanisms of the disease. Graphical diagrams are provided in each chapter for ease of comprehension.


The Endothelium

The Endothelium
Author: Michel Félétou
Publisher: Morgan & Claypool Publishers
Total Pages: 309
Release: 2011
Genre: Science
ISBN: 1615041230

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The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References


How Tobacco Smoke Causes Disease

How Tobacco Smoke Causes Disease
Author: United States. Public Health Service. Office of the Surgeon General
Publisher:
Total Pages: 728
Release: 2010
Genre: Government publications
ISBN:

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This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.


Stress Response

Stress Response
Author: Stephen M. Keyse
Publisher: Springer Science & Business Media
Total Pages: 480
Release: 2007-10-26
Genre: Science
ISBN: 1592590543

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Mammalian cells have evolved a complex multicomponent machinery that enables them to sense and respond to a wide variety of potentially toxic agents present in their environment. These stress responses are often associated with an increased cellular capacity to tolerate normally lethal levels of an insult. The realization that the mammalian stress response may be intimately linked with many human diseases, including rheumatoid arthritis, ischemia, fever, infection, and cancer, has led to an explosion of interest in this research area. Stress Response: Methods and Protocols brings together a diverse array of practical methodologies that may be employed to address various aspects of the response of mammalian cells to environmental stress. The p- tocols are carefully described by authors who have both devised and succe- fully employed them, and they represent a mixture not only of well-established techniques, but also new technologies at the leading edge of research. The areas covered include the detection and assay of stress-induced damage, the acti- tion of signal transduction pathways, stress-inducible gene expression, and stress protein function. Although no volume of this size can be comprehensive and the topics covered reflect a personal choice, it is hoped that it will prove of subst- tial interest and use to a wide range of research workers in the field.


Hypoxia

Hypoxia
Author: Robert C. Roach
Publisher: Springer Science & Business Media
Total Pages: 466
Release: 2002-01-31
Genre: Medical
ISBN: 9780306466960

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Hypoxia remains a constant threat throughout life. It is for this reason that the International Hypoxia Society strives to maintain a near quarter century tradition of presenting a stimulating blend of clinical and basic science discussions. International experts from many fields have focused on the state-of-the-art discoveries in normal and pathophysiological responses to hypoxia. Topics in this volume include gene-environment interactions, a theme developed in both a clinical context regarding exercise and hypoxia, as well as in native populations living in high altitudes. Furthermore, experts in the field have combined topics such as skeletal muscle angiogenesis and hypoxia, high altitude pulmonary edema, new insights into the biology of the erythropoietin receptor, and the latest advances in cardiorespiratory control in hypoxia. This volume explores the fields of anatomy, cardiology, biological transport, and biomedical engineering among many others.


Dietary Phytochemicals

Dietary Phytochemicals
Author: Chukwuebuka Egbuna
Publisher: Springer Nature
Total Pages: 262
Release: 2021-08-20
Genre: Science
ISBN: 3030729990

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This book presents comprehensive coverage on the importance of good nutrition in the treatment and management of obesity, cancer and diabetes. Naturally occurring bioactive compounds are ubiquitous in most dietary plants available to humans and provide opportunities for the management of diseases. The text provides information about the major causes of these diseases and their association with nutrition. The text also covers the role of dietary phytochemicals in drug development and their pathways. Later chapters emphasize novel bioactive compounds as anti-diabetic, anti-cancer and anti-obesity agents and describe their mechanisms to regulate cell metabolism. Written by global team of experts, Dietary Phytochemicals: A Source of Novel Bioactive Compounds for the Treatment of Obesity, Cancer and Diabetes describes the potentials of novel phytochemicals, their sources, and underlying mechanism of action. The chapters were drawn systematically and incorporated sequentially to facilitate proper understanding. This book is intended for nutritionists, physicians, medicinal chemists, drug developers in research and development, postgraduate students and scientists in area of nutrition and life sciences.