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Author | : Peter G. M. Wuts |
Publisher | : John Wiley & Sons |
Total Pages | : 1108 |
Release | : 2012-12-20 |
Genre | : Science |
ISBN | : 1118589327 |
Download Greene's Protective Groups in Organic Synthesis Book in PDF, ePub and Kindle
The Fourth Edition of Greene's Protective Groups in Organic Synthesis continues to be an indispensable reference for controlling the reactivity of the most common functional groups during a synthetic sequence. This new edition incorporates the significant developments in the field since publication of the third edition in 1998, including... New protective groups such as the fluorous family and the uniquely removable 2-methoxybenzenesulfonyl group for the protection of amines New techniques for the formation and cleavage of existing protective groups, with examples to illustrate each new technique Expanded coverage of the unexpected side reactions that occur with protective groups New chart covering the selective deprotection of silyl ethers 3,100 new references from the professional literature The content is organized around the functional group to be protected, and ranges from the simplest to the most complex and highly specialized protective groups.
Author | : J. McOmie |
Publisher | : Springer Science & Business Media |
Total Pages | : 423 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 1468472186 |
Download Protective Groups in Organic Chemistry Book in PDF, ePub and Kindle
During the past decade there has been a great increase in the use of protective groups, especially in the synthesis of large and complex organic molecules. Perhaps the greatest activity has been in the peptide field where such triumphs as the total synthesis of insulin and of bovine ribonuclease (molecular weight 13,700) have been achieved. Correspondingly, more protective groups have been devised for the protection of amino and imino groups than for any other functional group. There are many reviews and books on the synthesis of pep tides but there has been no general survey of protective groups since my 1 own review in 1963. At that time the five main methods for the removal of protective groups involved acid or base hydroly sis, reduction, oxidation, or thermal elimination reactions. Recent advances include the use of photo-sensitive and metal ion sensitive protective groups, and the attachment of functional groups to reactive polymers as a method of protec tion during the solid-phase synthesis of peptides and poly nucleotides. Another interesting development is the design and use of protective groups with a built-in 'safety-catch', which can be 'released' by a specific chemical reaction, so that an otherwise stable bond is made labile at the appropriate moment thereby allowing the protective group to be removed under very 2 mild conditions. My own interest in protective groups dates from 1944 when, as a student, I gave two lectures on the subject and produced an 11 page review including 70 references.
Author | : Philip J. Kocienski |
Publisher | : Thieme |
Total Pages | : 700 |
Release | : 2005 |
Genre | : Organic compounds |
ISBN | : 9781588903761 |
Download Protecting Groups Book in PDF, ePub and Kindle
The didactic presentation of the material makes this book an essential bench-top tool not only for specialists in organic chemistry, but also for students and all those involved in the preparation of organic molecules. Key Features: A critical survey of the most used protecting groups, as used by organic chemists Organization based on functional groups: hydroxyl ; diol; carbonyl; carboxyl; amine Special emphasis placed on deprotection conditions applied to complex structures where selectivity is a prime issue Transformations accompanied by key experimental details Examples from the recent literature span a wide domain of organic synthesis Over 500 schemes aid visual retrieval End-of-chapter list reviews which amplify topics covered.
Author | : Sebastien Vidal |
Publisher | : John Wiley & Sons |
Total Pages | : 522 |
Release | : 2019-04-29 |
Genre | : Science |
ISBN | : 3527340106 |
Download Protecting Groups: Strategies and Applications in Carbohydrate Chemistry Book in PDF, ePub and Kindle
A unique overview of the most important protecting group strategies in carbohydrate chemistry Protecting Groups: Strategies and Applications in Carbohydrate Chemistry provides a detailed account of key strategies and methodologies for the protection of carbohydrates. Divided into two parts, the first focuses on groups that are used best to protect a specific position on a carbohydrate. In the second part, specific carbohydrate residues or compounds are discussed in the context of a specific protecting group strategy used to reach the desired regioisomer. This important book: -Features chapters on protecting groups at the primary and secondary positions of carbohydrates -Describes protecting group strategies towards sialic acid derivatives, glycofuranoses, sulfated glycosaminoglycans, and cyclodextrins -Provides information on automated glycan assembly -Includes a chapter on the industrial scale synthesis of heparin analogs Written by a team of leaders in the field, Protecting Groups: Strategies and Applications in Carbohydrate Chemistry is an indispensable guide for academics and industrial researchers interested in carbohydrate and natural product synthesis, pharmaceutical chemistry, and biochemistry.
Author | : Theodora W. Greene |
Publisher | : |
Total Pages | : 376 |
Release | : 1981-05-14 |
Genre | : Science |
ISBN | : |
Download Protective Groups in Organic Synthesis Book in PDF, ePub and Kindle
Provides comprehensive information on the most useful protective groups for the hydroxyl, amino, carboxyl, carbonyl, and sulfhydryl groups. Discusses the chemistry of the classes of protective groups, as well as that of the individual protective groups within the class using structures, equations and references. Reactivity Charts for each class of protective group serve as an aid in their appropriate choice and provide estimates of their relative reactivities toward 108 prototype reagents.
Author | : Peter G. M. Wuts |
Publisher | : John Wiley & Sons |
Total Pages | : 1400 |
Release | : 2014-08-08 |
Genre | : Science |
ISBN | : 1118905121 |
Download Greene's Protective Groups in Organic Synthesis Book in PDF, ePub and Kindle
An indispensable reference for any practicing synthetic organic ormedicinal chemist, this book continues the tradition ofGreene’s as comprehensive in the overall scope of coverage,providing the most relevant and useful examples to illustrate eachmethodology. • Presents valuable material, on the application ofprotective groups in organic chemistry, that is not easily found bycasual searching • Helps chemists to plan, investigate, and carry outorganic syntheses in an efficient manner • Adds over 2800 new references to update since thepublication of the last edition • Reviews of the prior edition: "An essential bible forthe library or personal bookshelf of chemists performing complexsynthesis." (CHOICE, May 2007) "...the most up-to-date compilationavailable...should be an integral part of all institutionallibraries...it is also highly recommended thatindividuals...maintain their own copy..." (Journal of MedicinalChemistry, March 8, 2007) "...continues to be a comprehensive guideto the techniques for the formation and cleavage of protectivegroups." (Journal of the American Chemical Society, January 31,2007)
Author | : James Ralph Hanson |
Publisher | : Blackwell Science Incorporated |
Total Pages | : 130 |
Release | : 1999-01-01 |
Genre | : Science |
ISBN | : 9780632045068 |
Download Protecting Groups in Organic Synthesis Book in PDF, ePub and Kindle
Author | : Jeremy Robertson |
Publisher | : |
Total Pages | : 97 |
Release | : 2008 |
Genre | : Organic compounds |
ISBN | : 9780191848667 |
Download Protecting Group Chemistry Book in PDF, ePub and Kindle
'Protecting Group Chemistry' provides an overview of methods that allow specific sites within an organic molecule to be manipulated without affecting other sites. The author emphasises the link between the mechanisms of organic chemistry and the choice of specific protecting groups that block chemical reactivity at those sites that must remain unaffected.
Author | : John D. Roberts |
Publisher | : |
Total Pages | : 1596 |
Release | : 1977 |
Genre | : Chemistry, Organic |
ISBN | : 9780805383218 |
Download Basic Principles of Organic Chemistry Book in PDF, ePub and Kindle
Introduction what is organic chemistry all about?; Structural organic chemistry the shapes of molecules functional groups; Organic nomenclature; Alkanes; Stereoisomerism of organic molecules; Bonding in organic molecules atomic-orbital models; More on nomenclature compounds other than hydrocarbons; Nucleophilic substitution and elimination reactions; Separation and purification identification of organic compounds by spectroscopic techniques; Alkenes and alkynes. Ionic and radical addition reactions; Alkenes and alkynes; Oxidation and reduction reactions; Acidity or alkynes.
Author | : Roman Valiulin |
Publisher | : Walter de Gruyter GmbH & Co KG |
Total Pages | : 249 |
Release | : 2020-04-20 |
Genre | : Science |
ISBN | : 3110608375 |
Download Organic Chemistry: 100 Must-Know Mechanisms Book in PDF, ePub and Kindle
This book summarizes 100 essential mechanisms in organic chemistry ranging from classical such as the Reformatsky Reaction from 1887 to recently elucidated mechanism such as the copper(I)-catalyzed alkyne-azide cycloaddition. The reactions are easy to grasp, well-illustrated and underpinned with explanations and additional information.