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Critical Issues in Head and Neck Oncology

Critical Issues in Head and Neck Oncology
Author: Jan B. Vermorken
Publisher: Springer Nature
Total Pages: 363
Release: 2021-06-02
Genre: Medical
ISBN: 3030632342

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This open access book discusses the most current issues in head and neck cancer with a focus on current trends such as biomarkers, precision medicine and immunotherapy. New approaches in the diagnosis such as liquid biopsies and imaging biomarkers to predict radiotherapy toxicity as well as approaches in the surgical management of head and neck cancers are discussed. The book discusses medical and surgical approaches in both primary, recurrent and metastatic disease and also covers approaches for rare head neck cancers. Readers will learn about the latest drug developments and epidemiological aspects in cancers ranging from Head and Neck Squamous Cell Cancer to Nasopharynx cancer. Edited by a team of world leaders in Head and Neck Cancer, this volume serves as an easy reference to the head and neck oncology practitioner and provides a contemporary overview for specialists the field. The chapters are based on the latest data presented at the 7th Trends in Head and Neck Oncology Conference and reflect the most up-to-date information in the field.


Molecular Determinants of Head and Neck Cancer

Molecular Determinants of Head and Neck Cancer
Author: Barbara Burtness
Publisher: Springer Science & Business Media
Total Pages: 360
Release: 2014-04-08
Genre: Medical
ISBN: 146148815X

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Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. In the past several years, there have been significant developments in understanding of HNC. It is now recognized that although alcohol and tobacco use has represented the likely predominant cause of SCCHN, the incidence of a second class of SCCHN related to oncogenic human papillomavirus (HPV) infection is increasing, with a four-fold increase in the past 2 decades, and now thought to represent up to 30% of cases. The first effective target for SCCHN, the EGFR-targeting antibody cetuximab, was approved as recently as in 2006; since then, a growing body of research has identified additional signaling pathways as important in disease pathogenesis, and in resistance to treatment. Proteins such as c-Met, Src, and HER2 are emerging as new therapeutic targets, with a considerable ferment in the clinical trial community. As a capstone of research progress, 2011 marked the first reports of high throughput sequencing of SCCHN tumors, with these efforts identifying unexpected players such as Notch as frequent subject of mutation, spawning new hypotheses for future research. This book will be of interest to researchers who are interested in better understanding the biology of head and neck cancers, with the goals of better designing therapies, identifying risk factors, or investigating the molecular basis of the disease.


High-Risk Cutaneous Squamous Cell Carcinoma

High-Risk Cutaneous Squamous Cell Carcinoma
Author: Chrysalyne D. Schmults
Publisher: Springer
Total Pages: 261
Release: 2016-04-29
Genre: Medical
ISBN: 3662470810

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This book is a cutting-edge resource that provides clinicians with the up-to-date practical knowledge required in order to manage SCC patients optimally. It summarizes newly available information relating to the definition of high-risk SCC, its pathophysiologic underpinnings, and its management. New prognostic information and staging systems are summarized that enable high-risk tumors to be defined more precisely than ever before. Many helpful tips are provided on the practical management of challenging cases, including multiple tumors/field cancerization, high-risk tumors, nodal metastases, and unresectable disease. The authors are all acknowledged experts in the emerging field of high-risk and advanced SCC.​


Head and Neck Tumor Segmentation and Outcome Prediction

Head and Neck Tumor Segmentation and Outcome Prediction
Author: Vincent Andrearczyk
Publisher: Springer Nature
Total Pages: 339
Release: 2022-03-12
Genre: Computers
ISBN: 303098253X

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This book constitutes the Second 3D Head and Neck Tumor Segmentation in PET/CT Challenge, HECKTOR 2021, which was held in conjunction with the 24th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2021. The challenge took place virtually on September 27, 2021, due to the COVID-19 pandemic. The 29 contributions presented, as well as an overview paper, were carefully reviewed and selected form numerous submissions. This challenge aims to evaluate and compare the current state-of-the-art methods for automatic head and neck tumor segmentation. In the context of this challenge, a dataset of 325 delineated PET/CT images was made available for training.


Head and Neck Tumor Segmentation and Outcome Prediction

Head and Neck Tumor Segmentation and Outcome Prediction
Author: Vincent Andrearczyk
Publisher: Springer Nature
Total Pages: 269
Release: 2023-03-17
Genre: Computers
ISBN: 3031274202

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This book constitutes the Third 3D Head and Neck Tumor Segmentation in PET/CT Challenge, HECKTOR 2022, which was held in conjunction with the 25th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2022, on September 22, 2022. The 22 contributions presented, as well as an overview paper, were carefully reviewed and selected from 24 submissions. This challenge aims to evaluate and compare the current state-of-the-art methods for automatic head and neck tumor segmentation. In the context of this challenge, a dataset of 883 delineated PET/CT images was made available for training.


Prognostic Markers in Head and Neck Cancers

Prognostic Markers in Head and Neck Cancers
Author: Priyanka Manchanda
Publisher: LAP Lambert Academic Publishing
Total Pages: 176
Release: 2015-01-16
Genre:
ISBN: 9783659628962

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Head and neck squamous cell carcinoma is the sixth most common cancer in the world. Oral cancer accounts for nearly 50% of all newly diagnosed cancers in India. Oral cavity cancers are the most common cancers in males and the third most common in females in India. Majority of them are associated with tobacco chewing and usually preceded by premalignant lesions.On an average, about 1% of oral lesions transform into cancer annually.15 to 20% of dysplastic lesions develop into carcinoma.One of the primary reasons for the poor prognosis is the lack of significant and unique molecular tumor markers to assess risk and prognosis. Identification of better prognostic factors is necessary to assist in more accurate lesional staging and prediction of prognosis.