Prion Diseases PDF Download
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| Author | : |
| Publisher | : Elsevier |
| Total Pages | : 512 |
| Release | : 2018-06-07 |
| Genre | : Medical |
| ISBN | : 0444639535 |
Download Human Prion Diseases Book in PDF, ePub and Kindle
Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems. Offers an authoritative overview of prion diseases in humans, detailing the pathogenesis of the disease, clinical investigations, and the diagnosis of both the genetic and acquired forms Provides clarity and context by presenting prion diseases in relation to other neurodegenerative diseases in humans Emphasizes the unique properties of prion diseases and consequent problems they can cause, both clinically and in public health terms
| Author | : John Collinge (MD.) |
| Publisher | : |
| Total Pages | : 226 |
| Release | : 1997 |
| Genre | : Medical |
| ISBN | : |
Download Prion Diseases Book in PDF, ePub and Kindle
The number of neurological conditions associated with the mutant "prion" protein continues to grow. The list includes BSE and scrapie, which affect cattle and sheep respectively, and Creutzfeldt-Jacob Disease, which affects humans. This is an area of intense interest to neuroscientists,veterinary scientists, and clinicians. It has also attracted significant media attention because of the potential risks to humans. This book brings together leading researchers in the field to provide the most up-to-date and authoritative summary available of the field. Contents include human and animal prion diseases; pathology and cell biology of prion diseases; and prion protein structure.
| Author | : Stanley B. Prusiner |
| Publisher | : Yale University Press |
| Total Pages | : 344 |
| Release | : 2014-04-29 |
| Genre | : Science |
| ISBN | : 0300191146 |
Download Madness and Memory Book in PDF, ePub and Kindle
The author, a 1997 recipient of the Noble Prize in medicine, describes the years he spent researching and demonstrating how the infectious proteins known as prions were responsible for brain diseases and how his theory has now become widely accepted in the science establishment.
| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 125 |
| Release | : 2003-03-20 |
| Genre | : Medical |
| ISBN | : 0309168597 |
Download Advancing Prion Science Book in PDF, ePub and Kindle
In Advancing Prion Science, the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense's National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions' normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEs' from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment. This report summarizes the progress thus far.
| Author | : Wen-Quan Zou |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 322 |
| Release | : 2012-11-08 |
| Genre | : Medical |
| ISBN | : 1461453380 |
Download Prions and Diseases Book in PDF, ePub and Kindle
Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.
| Author | : Wen-Quan Zou |
| Publisher | : Springer Nature |
| Total Pages | : 773 |
| Release | : 2023-01-01 |
| Genre | : Medical |
| ISBN | : 3031205650 |
Download Prions and Diseases Book in PDF, ePub and Kindle
Transmissible spongiform encephalopathies (TSE), known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. Modern studies, including the protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In the second edition of Prions and Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date discussion of these unique infectious pathogens and their associated diseases. The book provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the full range of animal and human prion diseases. As a result, the book contains by far the most authoritative views about the past, present, and future of prions and prion diseases. The new second edition covers such important emerging topics such as inherited human prion disease, stem-cell models in prion research, human prion disease surveillance, and gene therapy strategies.
| Author | : Gabor G. Kovacs |
| Publisher | : Cambridge University Press |
| Total Pages | : 320 |
| Release | : 2017-12-13 |
| Genre | : Medical |
| ISBN | : 1316337650 |
Download Neuropathology of Neurodegenerative Diseases Book in PDF, ePub and Kindle
This practical guide to the diagnosis of neurodegenerative diseases discusses modern molecular techniques, morphological classification, fundamentals of clinical symptomology, diagnostic pitfalls and immunostaining protocols. It is based on the proteinopathy concept of neurodegenerative disease, which has influenced classification and provides new strategies for therapy. Numerous high-quality images, including histopathology photomicrographs and neuroradiology scans, accompany the description of morphologic alterations and interpretation of immunoreactivities. Diagnostic methods and criteria are placed within recent developments in neuropathology, including the now widespread application of immunohistochemistry. To aid daily practice, the guide includes diagnostic algorithms and offers personal insights from experienced experts in the field. Special focus is given to the way brain tissue should be handled during diagnosis. This is a must-have reference for medical specialists and specialist medical trainees in the fields of pathology, neuropathology and neurology working with neuropathologic features of neurodegenerative diseases.
| Author | : David R. Brown |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 498 |
| Release | : 2005-05-06 |
| Genre | : Medical |
| ISBN | : 9780387239224 |
Download Neurodegeneration and Prion Disease Book in PDF, ePub and Kindle
This is the first and only book on the subject of prions to cover the cause of cell death in the disease. It covers the full range of competing theories on the subject, from broad description and basic points up to the final details of the basic science.
| Author | : Philip Yam |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 290 |
| Release | : 2007-05-08 |
| Genre | : Medical |
| ISBN | : 038721755X |
Download The Pathological Protein Book in PDF, ePub and Kindle
Prions are an entirely new class of pathogens, and scientists are just beginning to understand them. Although they have plagued humans and animals for 3 centuries, only in the last 2 decades have researchers linked them to diseases like Mad Cow. This book tells the strange story of their discovery, and the medical controversies that swirl around them. The author, Philip Yam, is a well-respected and connected journalist who is now an editor at Scientific American.
| Author | : Martin H. Groschup |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 284 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3709163080 |
Download Prion Diseases Book in PDF, ePub and Kindle
The overwhelming interest and the participation of more than 500 scientists from 26 countries made this symposium the largest meeting ever held in the field. In this book twenty-six invited speakers comprehensively present their data on the pathogenesis of prion diseases in humans and animals, on molecular mechanisms involved in the transmissibility across species barriers, on animal and in-vitro models currently available for the detection and quantification of infectivity and on the characterization of prion strains.
