Principles Of Antineoplastic Drug Development And Pharmacology PDF Download
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Author | : Richard L. Schilsky |
Publisher | : CRC Press |
Total Pages | : 760 |
Release | : 1996-06-27 |
Genre | : Medical |
ISBN | : 9780824793142 |
Download Principles of Antineoplastic Drug Development and Pharmacology Book in PDF, ePub and Kindle
Reviews the principles of drug development and clinical pharmacology applicable to all classes of anticancer drugs. Covers every aspect of drug development--from drug discovery to approval and routine use. Details how the successful application of pharmacological principles can improve drug delivery, individualized dosing, and the circumvention of drug resistance; elucideates proven strategies for widening the therapeutic margin between antitumor effects and severe toxicity; and more.
Author | : Elizabeth Garrett-Mayer |
Publisher | : Springer Science & Business Media |
Total Pages | : 673 |
Release | : 2010-12-29 |
Genre | : Medical |
ISBN | : 1441973583 |
Download Principles of Anticancer Drug Development Book in PDF, ePub and Kindle
A practical guide to the design, conduction, analysis and reporting of clinical trials with anticancer drugs.
Author | : Wolfgang Link |
Publisher | : Springer Nature |
Total Pages | : 145 |
Release | : 2019-09-10 |
Genre | : Medical |
ISBN | : 3030187225 |
Download Principles of Cancer Treatment and Anticancer Drug Development Book in PDF, ePub and Kindle
This book explains how current medicines against cancer work and how we find new ones. It provides an easy-to-understand overview of current options to treat patients with cancer, which includes Surgery, Radiation therapy, Chemotherapy, Targeted therapy and Immunotherapy. The efficiency of all these treatments is limited by the capacity of cancer cells to escape therapy. This book explains the mechanisms of anti-cancer drug resistance and strategies to overcome it. The discovery and development process of a new drug is detailed beginning with the identification and validation of a therapeutic target, the identification of an inhibitor of the target and its subsequent preclinical and clinical development until its approval by regulatory authorities. Particular emphasis has been given to specific aspects of the development process including lead generation and optimization, pharmacokinetics, ADME analysis, pharmacodynamics, toxicity and efficacy assessment, investigational new drug (IND) and new drug application (NDA) and the design of clinical trial and their phases. The book covers many aspects of modern personalized oncology and discusses economic aspects of our current system of developing new medicines and its impact on our societies and on future drug research. The author of this book, Dr. Link counts with more than 20 years of experience in biomedical research reflected in numerous publications, patents and key note and plenary presentations at international conferences. Interested readers, students and teachers should read this book as it provides a unique way to learn/teach about basic concepts in oncology and anti-cancer drug research.
Author | : Wolfgang Alexander Link |
Publisher | : |
Total Pages | : 145 |
Release | : 2019 |
Genre | : Cancer |
ISBN | : 9783030187231 |
Download Principles of Cancer Treatment and Anticancer Drug Development Book in PDF, ePub and Kindle
This book explains how current medicines against cancer work and how we find new ones. It provides an easy-to-understand overview of current options to treat patients with cancer, which includes Surgery, Radiation therapy, Chemotherapy, Targeted therapy and Immunotherapy. The efficiency of all these treatments is limited by the capacity of cancer cells to escape therapy. This book explains the mechanisms of anti-cancer drug resistance and strategies to overcome it. The discovery and development process of a new drug is detailed beginning with the identification and validation of a therapeutic target, the identification of an inhibitor of the target and its subsequent preclinical and clinical development until its approval by regulatory authorities. Particular emphasis has been given to specific aspects of the development process including lead generation and optimization, pharmacokinetics, ADME analysis, pharmacodynamics, toxicity and efficacy assessment, investigational new drug (IND) and new drug application (NDA) and the design of clinical trial and their phases. The book covers many aspects of modern personalized oncology and discusses economic aspects of our current system of developing new medicines and its impact on our societies and on future drug research. The author of this book, Dr. Link counts with more than 20 years of experience in biomedical research reflected in numerous publications, patents and key note and plenary presentations at international conferences. Interested readers, students and teachers should read this book as it provides a unique way to learn/teach about basic concepts in oncology and anti-cancer drug research.
Author | : Bruce A. Chabner |
Publisher | : Lippincott Williams & Wilkins |
Total Pages | : 836 |
Release | : 2011-12-07 |
Genre | : Medical |
ISBN | : 1451148208 |
Download Cancer Chemotherapy and Biotherapy Book in PDF, ePub and Kindle
Updated to include the newest drugs and those currently in development, this Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised. A companion website includes the fully searchable text and an image bank.
Author | : Stephen Neidle |
Publisher | : Elsevier |
Total Pages | : 496 |
Release | : 2011-04-28 |
Genre | : Medical |
ISBN | : 9780080554952 |
Download Cancer Drug Design and Discovery Book in PDF, ePub and Kindle
The ultimate source of information on the design of new anticancer agents, emphasizing small molecules, this newest work covers recent notable successes resulting from the human genome and cancer genomics projects. These advances have provided information on targets involved in specific cancers that are leading to effective medicines for at least some of the common solid tumors. Unique sections explain the basic underlying principles of cancer drug development and provide a practical introduction to modern methods of drug design. Appealing to a broad audience, this is an excellent reference for translational researchers interested in cancer biology and medicine as well as students in pharmacy, pharmacology, or medicinal and biological chemistry and clinicians taking oncology options. * Covers both currently available drugs as well as those under development * Provides a clinical perspective on trials of new anticancer agents * Presents drug discovery examples through the use of case histories
Author | : Robert C. Bast, Jr. |
Publisher | : John Wiley & Sons |
Total Pages | : 2008 |
Release | : 2017-03-10 |
Genre | : Medical |
ISBN | : 111900084X |
Download Holland-Frei Cancer Medicine Book in PDF, ePub and Kindle
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author | : Binghe Wang |
Publisher | : John Wiley & Sons |
Total Pages | : 740 |
Release | : 2016-04-18 |
Genre | : Science |
ISBN | : 1118833368 |
Download Drug Delivery Book in PDF, ePub and Kindle
Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference. • Helps readers understand progress in drug delivery research and applications • Updates and expands coverage to reflect advances in materials for delivery vehicles, drug delivery approaches, and therapeutics • Covers recent developments including transdermal and mucosal delivery, lymphatic system delivery, theranostics • Adds new chapters on nanoparticles, controlled drug release systems, theranostics, protein and peptide drugs, and biologics delivery
Author | : Bruce Chabner |
Publisher | : |
Total Pages | : 879 |
Release | : 2006 |
Genre | : Medical |
ISBN | : 0781756286 |
Download Cancer Chemotherapy and Biotherapy Book in PDF, ePub and Kindle
Updated to include the newest drugs and those currently in development, this Fourth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition provides expanded coverage of monoclonal antibodies, molecularly targeted drugs, vaccines, cell based therapies, growth factors, and pharmacogenetics.
Author | : H. J. Smith |
Publisher | : Elsevier |
Total Pages | : 306 |
Release | : 2016-06-14 |
Genre | : Medical |
ISBN | : 1483183505 |
Download Introduction to the Principles of Drug Design Book in PDF, ePub and Kindle
Introduction to the Principles of Drug Design provides a framework of fundamental drug design and principles into which drugs following on developments may be fitted. This book presents the rationales behind the design of drugs. Organized into nine chapters, this book begins with an overview of how the body handles a drug in terms of absorption, metabolism, distribution, and excretion. This text then examines the critical drug activity at the receptor site, which is usually related to blood and other distribution fluid levels. Other chapters consider the factors involved in binding a drug, metabolite, or substrate to a receptor. The final chapter deals with the design of chemotherapeutic agent for clinical use in the treatment of human infections. This book is intended for use in undergraduate pharmacy courses in medicinal chemistry and as an aid in similar courses in biochemistry and pharmacology. Graduates in chemistry just entering the pharmaceutical industry will also find this book useful.