Pnh And The Gpi Linked Proteins PDF Download
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| Author | : Neal S. Young |
| Publisher | : Elsevier |
| Total Pages | : 279 |
| Release | : 2000-04-28 |
| Genre | : Medical |
| ISBN | : 9780080492094 |
Download PNH and the GPI-Linked Proteins Book in PDF, ePub and Kindle
Paroxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctive biochemical and physical characteristics. Recently it has been acknowledged that PNH is not rare, and once sensitive assays--based on the chemistry of the proteins--can be applied to many patients. Written by international experts in the field, this book includes a number of distinctive characteristics, such as the clinical features of PNH, the mechanism of hemolysis, the biochemistry of glycosylphosphoinositol anchors, and the chemistry and biophysics of GPI-anchored proteins. This unique and timely volume will have a wide audience, including hematologists and oncologists with a clinical interest in this disease, as well as basic biochemists, immunologists, and cell biologists studying this class of proteins. Outlines the chemical features of PNH Explains the mechanism of hemolysis Includes work on the biochemistry of glycophosphoinositol anchors Contains descriptions of the chemistry and biophysics of GPI-anchored proteins
| Author | : Yuzuru Kanakura |
| Publisher | : Springer |
| Total Pages | : 358 |
| Release | : 2017-01-16 |
| Genre | : Medical |
| ISBN | : 4431560033 |
Download Paroxysmal Nocturnal Hemoglobinuria Book in PDF, ePub and Kindle
This volume reviews the fundamental understanding of this potentially life-threatening disease and the advances in treatment that have been achieved with the use of the monoclonal antibody eculizumab. Although the PIGA gene has been known for many years, the mechanism of clonal dominance in paroxysmal nocturnal hemoglobinuria is still largely unknown. This book, Paroxysmal Nocturnal Hemoglobinuria, discusses the direction of continuing research in this area, as well as the potential for the development of management guidelines. It serves as a valuable source of information for both basic scientists and physicians, especially immunologists targeting GPI-anchored proteins and complements, and hematologists specializing in bone marrow failure.
| Author | : Mahmoud Deeb Aljurf |
| Publisher | : Elsevier |
| Total Pages | : 274 |
| Release | : 2016-12-23 |
| Genre | : Science |
| ISBN | : 0128041757 |
Download Congenital and Acquired Bone Marrow Failure Book in PDF, ePub and Kindle
Congenital and Acquired Bone Marrow Failure is a comprehensive guide to congenital and acquired bone marrow failure in adult and pediatric patients. Chapters are divided into two sections, acquired aplastic anemia and inherited bone marrow failure syndromes. Content ranges from the basic, to the translational, and from the epidemiology of acquired aplastic anemia and telomere biology, to the management, treatment, and supportive care of pediatric, adult, and geriatric patients. Contributors are world leading experts in the field of bone marrow failure. The book is required reading for residents, fellows, clinicians, and researchers across hematology, oncology, pathology, bone marrow transplantation, pediatrics, and internal medicine. Provides an overview of all congenital and acquired bone marrow failure syndromes Focuses on the molecular pathogenesis, clinical manifestation and diagnosis, laboratory features, and treatment of each disease within the syndromes Features the area of supportive care which is a topic of great interest to infectious disease physicians and those involved in transfusion services
| Author | : M. Omine |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 376 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 4431678670 |
Download Paroxysmal Nocturnal Hemoglobinuria and Related Disorders Book in PDF, ePub and Kindle
Few publications focus on the mysterious, genetically acquired disease paroxysmal nocturnal hemoglobinuria (PNH) and the related "intractable" disorders—aplastic anemia and myelodysplastic syndromes. Now, however, the latest understanding of the clinical and molecular genetic aspects of PNH is summarized here in the proceedings of the International Symposium held in Tokyo in 2001. Major topics reviewed include the molecular mechanisms of the PIG-A gene mutation; complement activation and inhibitors; experimental animal models; pathogenesis; the history of PNH research; the natural history of the disease; the mechanism of PNH clone expansion; the emergence of PNH clones under bone marrow failure syndromes; and treatment of the disease by immunosuppressive agents and stem cell transplantation. This book provides an invaluable summary of current research on the fundamental aspects of PNH pathology, presented by renowned experts in the field.
| Author | : Hubert Schrezenmeier |
| Publisher | : Cambridge University Press |
| Total Pages | : 410 |
| Release | : 2000 |
| Genre | : Medical |
| ISBN | : 9780521641012 |
Download Aplastic Anemia Book in PDF, ePub and Kindle
Comprehensive and up-to-date clinical reference, with an emphasis on treatment.
| Author | : Michael Andreeff |
| Publisher | : |
| Total Pages | : 424 |
| Release | : 1986 |
| Genre | : Science |
| ISBN | : |
Download Clinical Cytometry Book in PDF, ePub and Kindle
| Author | : Geoff Daniels |
| Publisher | : John Wiley & Sons |
| Total Pages | : 950 |
| Release | : 2013-01-16 |
| Genre | : Medical |
| ISBN | : 1118493540 |
Download Human Blood Groups Book in PDF, ePub and Kindle
Human Blood Groups is a comprehensive and fully referenced text covering both the scientific and clinical aspects of red cell surface antigens, including: serology, inheritance, biochemistry, molecular genetics, biological functions and clinical significance in transfusion medicine. Since the last edition, seven new blood group systems and over 60 new blood group antigens have been identified. All of the genes representing those systems have now been cloned and sequenced. This essential new information has made the launch of a third edition of Human Blood Groups, now in four colour, particularly timely. This book continues to be an essential reference source for all those who require clinical information on blood groups and antibodies in transfusion medicine and blood banking.
| Author | : Sa A. Wang |
| Publisher | : Springer |
| Total Pages | : 412 |
| Release | : 2018-06-04 |
| Genre | : Medical |
| ISBN | : 3319202790 |
Download Diagnosis of Blood and Bone Marrow Disorders Book in PDF, ePub and Kindle
This book focuses on hematopoietic and lymphoid neoplasms that initially present as peripheral blood abnormalities, with either cytopenias or elevated peripheral blood counts, as well as non-neoplastic conditions that may raise concern for a hematologic malignancy. The scope of the book includes myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), mixed myelodysplastic/myeloproliferative neoplasms (MDS/MPN), as well as lymphomas and lymphoid leukemias that typically present initially with peripheral blood abnormalities. Within each category, a comprehensive list of differential diagnoses is discussed. For each disease entity, the reader is updated with new molecular genetic data, biomarkers, and recent applications of immunophenotyping, and how to incorporate the new information in disease diagnosis and classifications is illustrated, including the use of diagnostic algorithms where appropriate. The book employs the revised WHO Classification of Hematopoietic Neoplasms for all disease entities. Diagnosis of Blood and Bone Marrow Disorders will serve as a very useful resource for pathologists, pathologists in training, hematologists and medical technologists who are involved in the clinical work-up of patients with bone marrow and blood neoplasms. It will provide a practical and concise yet comprehensive review.
| Author | : Robert V. Stick |
| Publisher | : Elsevier |
| Total Pages | : 496 |
| Release | : 2010-08-06 |
| Genre | : Science |
| ISBN | : 9780080927022 |
Download Carbohydrates: The Essential Molecules of Life Book in PDF, ePub and Kindle
This book provides the "nuts and bolts" background for a successful study of carbohydrates - the essential molecules that not only give you energy, but are an integral part of many biological processes. A question often asked is 'Why do carbohydrate chemistry?' The answer is simple: It is fundamental to a study of biology. Carbohydrates are the building blocks of life and enable biological processes to take place. Therefore the book will provide a taste for the subject of glycobiology. Covering the basics of carbohydrates and then the chemistry and reactions of carbohydrates this book will enable a chemist to gain essential knowledge that will enable them to move smoothly into the worlds of biochemistry, molecular biology and cell biology. * includes perspective from new co-author Spencer Williams, who enhances coverage of the connection between carbohydrates and life * describes the basic chemistry and biology of carbohydrates * reviews the concepts, synthesis, reactions, and biology of carbohydrates
| Author | : Christopher D. Hillyer |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 910 |
| Release | : 2006-10-18 |
| Genre | : Medical |
| ISBN | : 0443069816 |
Download Blood Banking and Transfusion Medicine Book in PDF, ePub and Kindle
Ever since the discovery of blood types early in the last century, transfusion medicine has evolved at a breakneck pace. This second edition of Blood Banking and Transfusion Medicine is exactly what you need to keep up. It combines scientific foundations with today's most practical approaches to the specialty. From blood collection and storage to testing and transfusing blood components, and finally cellular engineering, you'll find coverage here that's second to none. New advances in molecular genetics and the scientific mechanisms underlying the field are also covered, with an emphasis on the clinical implications for treatment. Whether you're new to the field or an old pro, this book belongs in your reference library. Integrates scientific foundations with clinical relevance to more clearly explain the science and its application to clinical practice. Highlights advances in the use of blood products and new methods of disease treatment while providing the most up-to-date information on these fast-moving topics Discusses current clinical controversies, providing an arena for the discussion of sensitive topics. Covers the constantly changing approaches to stem cell transplantation and brings you the latest information on this controversial topic.
