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Cellular Peptide Hormone Synthesis and Secretory Pathways

Cellular Peptide Hormone Synthesis and Secretory Pathways
Author: Jens F. Rehfeld
Publisher: Springer Science & Business Media
Total Pages: 245
Release: 2010-03-10
Genre: Science
ISBN: 3642118364

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The concept of hormonal regulation using intercellular peptide messengers dates back to the discovery of secretin in 1902. The concept was simple: A peptide is released from specific hormone producing cells, endocrine cells, into circulation upon stimulation of the cells. The peptide hormone travels via blood to its target, the cells of which are equipped with specific receptors for high-affinity binding of the particular peptide hormone. Receptor binding subsequently elicits action of the target cells. This concept has been seriously challenged by modern biochemistry and cell biology. Thus, it is now well established that the gene of a specific peptide hormone may be expressed in different types of endocrine cells, in neurons, and in some instances also in adipocytes, myocytes, osteoblasts, and immune cells. Today, only a few hormones – including the old master hormone insulin – represent the original endocrine paradigm. Instead, the widespread cellular synthesis now raises the qu- tion of how the body maintains the regulation of its functions by peptide hormones when a hormone may originate from a variety of cells.


Peptide Hormone Secretion

Peptide Hormone Secretion
Author: K. Siddle
Publisher: Oxford University Press, USA
Total Pages: 376
Release: 1990
Genre: Medical
ISBN:

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Polypeptide hormones play a central role in the regulation of biological processes from the minute-to-minute control of vital functions to the programming of birth, development, reproduction, and ageing. The first of a two-volume work on the methods of study used in this field, Peptide Hormone Secretion focuses on the isolation of polypeptide hormones and their identification and structural analysis, the development of sensitive bioassay and immunoassay techniques, and tissue localization of peptide hormones and their encoding MRNAs, as well as techniques for characterization of peptide hormone receptors. Ideal for graduate students and researchers, the book includes coverage of the general principles and strategies that the methods are based on, so the techniques will have a wide application to biologically active peptides involved in neurotransmission, growth regulations, differentiation, and vasoregulation.


Therapeutic Protein and Peptide Formulation and Delivery

Therapeutic Protein and Peptide Formulation and Delivery
Author: Zahra Shahrokh
Publisher:
Total Pages: 248
Release: 1997
Genre: Language Arts & Disciplines
ISBN:

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This volume reviews protein stability and the analytical and biophysical characterization of proteins. It emphasizes drug delivery approaches, especially local delivery through the skin. Including both academic and industrial perspectives from such companies as Genentech, Amgen, and Merck, the book also discusses novel drug delivery polymers and the development of pharmaceutical protein formulations.


Peptide Hormone Secretion

Peptide Hormone Secretion
Author: K. Siddle
Publisher:
Total Pages: 0
Release:
Genre: Peptide hormones
ISBN: 9781383047875

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The first volume of a two-volume work, this book focuses on procedures used in the isolation of polypeptide hormones and their identification and structural analysis. The second volume is entitled "Peptide Hormone Action".


Anatomy and Physiology

Anatomy and Physiology
Author: J. Gordon Betts
Publisher:
Total Pages: 0
Release: 2013-04-25
Genre:
ISBN: 9781947172807

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Growth Hormone in Adults

Growth Hormone in Adults
Author: Anders Juul
Publisher: Cambridge University Press
Total Pages: 536
Release: 2000-04-27
Genre: Medical
ISBN: 9780521641883

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This revised new edition reviews the substantial advances in our understanding of the vital role of growth hormone (GH) in maintaining adult health, and the resulting disorders from GH deficiency. The first edition, published in 1996, provided a pioneering overview of the subject; this new edition provides an even more comprehensive account, fully updated with the latest research, clinical applications, and references. The therapeutic benefits of GH treatment in GH deficiency are thoroughly evaluated, including effects on metabolism, cardiac function, exercise performance, psychosocial aspects, and aging and gender-specific effects. This compilation by the world's leading experts covers clinical investigation, diagnosis and treatment issues, and encompasses new knowledge of the control and action of GH secretion. This volume is the most authoritative, comprehensive, and detailed account available and will be an essential source of reference for all endocrinologists.


Cellular Peptide Hormone Synthesis and Secretory Pathways

Cellular Peptide Hormone Synthesis and Secretory Pathways
Author: Jens F. Rehfeld
Publisher: Springer
Total Pages: 239
Release: 2010-10-22
Genre: Science
ISBN: 9783642118357

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The concept of hormonal regulation using intercellular peptide messengers dates back to the discovery of secretin in 1902. The concept was simple: A peptide is released from specific hormone producing cells, endocrine cells, into circulation upon stimulation of the cells. The peptide hormone travels via blood to its target, the cells of which are equipped with specific receptors for high-affinity binding of the particular peptide hormone. Receptor binding subsequently elicits action of the target cells. This concept has been seriously challenged by modern biochemistry and cell biology. Thus, it is now well established that the gene of a specific peptide hormone may be expressed in different types of endocrine cells, in neurons, and in some instances also in adipocytes, myocytes, osteoblasts, and immune cells. Today, only a few hormones – including the old master hormone insulin – represent the original endocrine paradigm. Instead, the widespread cellular synthesis now raises the qu- tion of how the body maintains the regulation of its functions by peptide hormones when a hormone may originate from a variety of cells.


Peptidomics

Peptidomics
Author: Mikhail Soloviev
Publisher: John Wiley & Sons
Total Pages: 432
Release: 2007-12-21
Genre: Science
ISBN: 0470196491

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The definitive guide to peptidomics- a hands-on lab reference The first truly comprehensive book about peptidomics for protein and peptide analysis, this reference provides a detailed description of the hows and whys of peptidomics and how the techniques have evolved. With chapters contributed by leading experts, it covers naturally occurring peptides, peptidomics methods and new developments, and the peptidomics approach to biomarker discovery. Explaining both the principles and the applications, Peptidomics: Methods and Applications: * Features examples of applications in diverse fields, including pharmaceutical science, toxicity biomarkers, and neuroscience * Details the successful peptidomic analyses of biological material ranging from plants to mammals * Describes a cross section of analytical techniques, including traditional methodologies, emerging trends, and new techniques for high throughput approaches An enlightening reference for experienced professionals, this book is sufficiently detailed to serve as a step-by-step guide for beginning researchers and an excellent resource for students taking biotechnology and proteomics courses. It is an invaluable reference for protein chemists and biochemists, professionals and researchers in drug and biopharmaceutical development, analytical and bioanalytical chemists, toxicologists, and others.


Human Biochemistry

Human Biochemistry
Author: Gerald Litwack
Publisher: Academic Press
Total Pages: 883
Release: 2021-11-28
Genre: Science
ISBN: 032391053X

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Human Biochemistry, Second Edition provides a comprehensive, pragmatic introduction to biochemistry as it relates to human development and disease. Here, Gerald Litwack, award-wining researcher and longtime teacher, discusses the biochemical aspects of organ systems and tissue, cells, proteins, enzymes, insulins and sugars, lipids, nucleic acids, amino acids, polypeptides, steroids, and vitamins and nutrition, among other topics. Fully updated to address recent advances, the new edition features fresh discussions on hypothalamic releasing hormones, DNA editing with CRISPR, new functions of cellular prions, plant-based diet and nutrition, and much more. Grounded in problem-driven learning, this new edition features clinical case studies, applications, chapter summaries, and review-based questions that translate basic biochemistry into clinical practice, thus empowering active clinicians, students and researchers. Presents an update on a past edition winner of the 2018 Most Promising New Textbook (College) Award (Texty) from the Textbook and Academic Authors Association and the PROSE Award of the Association of American Publishers Provides a fully updated resource on current research in human and medical biochemistry Includes clinical case studies, applications, chapter summaries and review-based questions Adopts a practice-based approach, reflecting the needs of both researchers and clinically oriented readers


Hormonally Active Brain Peptides

Hormonally Active Brain Peptides
Author: Kenneth W. McKerns
Publisher: Springer Science & Business Media
Total Pages: 642
Release: 2013-11-11
Genre: Science
ISBN: 1461592488

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Near the end of September 1980, the contributors to Hormonally Active Brain Pep tides: Structure and Function met to discuss their chapters for the monograph. This meeting was the eighth sponsored by the International Foundation for Biochemical Endocrinology and was held at the Hotel Plakir in Dubrovnik, Yugoslavia. Several months were allowed after the meeting for the contributors to revise their manuscripts and for editing. Professor Dr. Vladimir Pantie and the Serbian Academy of Sciences and Arts were in charge of the local arrangements and social activities. The Foundation is grateful for the splendid job that was done and for the out standing scientific, cultural, and social activities. I thank the Serbian Acad emy of Sciences and Arts and the Yugoslav Council of Academies for spon soring my stay in Yugoslavia. I greatly enjoyed giving lectures, visiting laboratories, and discussing research projects in a number of centers in Yugoslavia. A diverse group of topics was presented in Dubrovnik concerning cer tain brain peptides. The topics included "Structure, Function, and Confor mation of Neuropeptides," "Distribution of Peptides in the Brain," "Reg ulation of the Release of Peptide Hormones," "The Active Center of Gonadotropins," "In Vitro Synthesis of Hypothalamic Hormones," "Stud ies on Gonadotropin-Releasing Hormone," "Studies on the Biosynthesis, Release, and Degradation of LH-RH," "Genesis and Properties of Pitu itary ACTH, Prolactin, and Growth Hormone Producing Cells," "Precur sors to Oligopeptide Hormones," and "Stress Effects on Peptide Hormone Synthesis