Peptide Drug Discovery And Development PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Peptide Drug Discovery And Development PDF full book. Access full book title Peptide Drug Discovery And Development.
| Author | : Miguel Castanho |
| Publisher | : John Wiley & Sons |
| Total Pages | : 547 |
| Release | : 2011-10-24 |
| Genre | : Medical |
| ISBN | : 3527636749 |
Download Peptide Drug Discovery and Development Book in PDF, ePub and Kindle
Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the "bench to bedside" translational approach to drug development. Clearly structured into three major parts, the book stakes out the boundaries of peptide drug development in the preclinical as well as clinical stages. The first part provides a general background and focuses on the characteristic strengths and weaknesses of peptide drugs. The second section contains five cases studies of peptides from diverse therapeutic fields, and the lessons to be learned from them, while the final part looks at new targets and opportunities, discussing several drug targets and diseases for which peptide drugs are currently being developed.
| Author | : Ved Srivastava |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 589 |
| Release | : 2017-06-26 |
| Genre | : Science |
| ISBN | : 1782627324 |
Download Peptide-based Drug Discovery Book in PDF, ePub and Kindle
With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies. What does it take to develop a peptide-based medicine? What are the key challenges and how are they overcome? What are emerging therapeutics for peptide modalities? This book answers these questions with a holistic story from molecules to medicine, combining the themes of design, synthesis and clinical applications of peptide-based therapeutics and biomarkers. Chapters are written and edited by leaders in the field from industry and academia and they cover the pharmacokinetics of peptide therapeutics, attributes necessary for commercially successful metabolic peptides, medicinal chemistry strategies for the design of peptidase-resistant peptide analogues, disease classes for which peptide therapeutic are most relevant, and regulatory issues and guidelines. The critical themes covered provide essential background information on what it takes to develop peptide-based medicine from a chemistry perspective and views on the future of peptide drugs. This book will be a valuable resource not only as a reference book for the researcher engaged in academic and pharmaceutical setting, from basic research to manufacturing and from organic chemistry to biotechnology, but also a valuable resource to graduate students to understand discovery and development process for peptide-based medicine.
| Author | : Ved Srivastava |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 572 |
| Release | : 2019-08-28 |
| Genre | : Science |
| ISBN | : 1788014332 |
Download Peptide Therapeutics Book in PDF, ePub and Kindle
Peptide therapy has become a key strategy in innovative drug development, however, one of the potential barriers for the development of novel peptide drugs in the clinic is their deficiencies in clearly defined chemistry, manufacturing and controls (CMC) strategy from clinical development to commercialization. CMC can often become a rate-limiting step due to lack of knowledge and lack of a formal policy or guidelines on CMC for peptide-based drugs. Regulators use a risk-based approach, reviewing applications on a case-by-case basis. Peptide Therapeutics: Strategy and Tactics for Chemistry, Manufacturing, and Controls covers efficient manufacturing of peptide drug substances, a review of the process for submitting applications to the regulatory authority for drug approval, a holistic approach for quality attributes and quality control from a regulatory perspective, emerging analytical tools for the characterisation of impurities, and the assessment of stability. This book is an essential reference work for students and researchers, in both academia and industry, with an interest in learning about CMC, and facilitating development and manufacture of peptide-based drugs.
| Author | : Ben M. Dunn |
| Publisher | : John Wiley & Sons |
| Total Pages | : 336 |
| Release | : 2015-02-02 |
| Genre | : Medical |
| ISBN | : 1118995287 |
Download Peptide Chemistry and Drug Design Book in PDF, ePub and Kindle
This book focuses on peptides as drugs, a growing area ofpharmaceutical research and development. It helps readers solveproblems of discovering, developing, producing, and deliveringpeptide-based drugs. • Identifies promising new areas in peptide drugdiscovery • Includes chapters on discovery from natural sources,metabolic modification, and drug delivery • Overviews separation methods and techniques foranalysis, bond formation, and purification • Offers readers both a professional reference and atext or resource for graduate-level students
| Author | : Nir Qvit |
| Publisher | : Academic Press |
| Total Pages | : 792 |
| Release | : 2022-09-22 |
| Genre | : Science |
| ISBN | : 0128204478 |
Download Peptide and Peptidomimetic Therapeutics Book in PDF, ePub and Kindle
Peptide and Peptidomimetic Therapeutics: From Bench to Beside offers applied, evidence-based instruction on developing and applying peptide therapeutics in disease treatment, driving drug discovery, and improving patient care. Here, researchers, clinicians and students will find tools to harness the full power of peptides and peptidomimetics and improve bioavailability, stability, efficiency and selectivity of new therapeutics and their application in treatment plans. More than 20 leaders in the field share their approaches for identifying and advancing peptide and peptidomimetic therapeutics. Topics examined run from "bench to bedside," beginning with fundamental peptide science, protein-protein interactions and peptide synthesis. Later chapters examine modes for peptide drug delivery, including cell penetration peptide and peptidomimetic delivery, as well as the targeting of specific disease types, peptide therapeutics as applied to infectious disease, cancer, metabolic disorders, neurodegenerative disorders, and skin disorders, and antiparasitic and immunosuppressive peptidomimetics. Helps researchers and clinicians harness the full of power of peptides and peptidomimetics in their daily work and drug discovery Features chapters running from “bench to bedside , providing a thorough grounding in fundamental peptide science, drug delivery methods, and targeting of specific disease types Features chapter contributions from international leaders in peptide science and drug development
| Author | : Bernd Groner |
| Publisher | : John Wiley & Sons |
| Total Pages | : 242 |
| Release | : 2009-11-18 |
| Genre | : Medical |
| ISBN | : 3527626840 |
Download Peptides as Drugs Book in PDF, ePub and Kindle
By covering the full spectrum of topics relevant to peptidic drugs, this timely handbook serves as an introductory reference for both drug developers and biomedical researchers interested in pharmaceutically active peptides, presenting both the advantages and challenges associated with this molecular class. The first part discusses current approaches to developing pharmaceutically active peptides, including case studies of the use of peptidic drugs in cancer and AIDS therapy. The second part surveys strategies for the development and targeting of peptidic drugs. With its integration of biochemical, pharmaceutical and clinical research, this work reveals the full picture of modern peptide drug research in a single volume, making it an invaluable reference for medicinal chemists, biochemists, biotechnologists, and those in the pharmaceutical and biotechnological industries.
| Author | : Ben M. Dunn |
| Publisher | : John Wiley & Sons |
| Total Pages | : 8 |
| Release | : 2015-03-09 |
| Genre | : Medical |
| ISBN | : 0470317612 |
Download Peptide Chemistry and Drug Design Book in PDF, ePub and Kindle
This book focuses on peptides as drugs, a growing area of pharmaceutical research and development. It helps readers solve problems of discovering, developing, producing, and delivering peptide-based drugs. • Identifies promising new areas in peptide drug discovery • Includes chapters on discovery from natural sources, metabolic modification, and drug delivery • Overviews separation methods and techniques for analysis, bond formation, and purification • Offers readers both a professional reference and a text or resource for graduate-level students
| Author | : Seetharama D. Jois |
| Publisher | : Springer Nature |
| Total Pages | : 321 |
| Release | : 2022-09-26 |
| Genre | : Medical |
| ISBN | : 3031045440 |
Download Peptide Therapeutics Book in PDF, ePub and Kindle
This book explains how peptide-based drug design works, what steps are needed to develop a peptide-based therapeutic, and challenges in synthesis as well as regulatory issues. It covers the design concept of peptide therapeutics from fundamental principles using structural biology and computational approaches. The chapters are arranged in a linear fashion. A fresh graduate or a scientist who works on small molecules can use this to follow the design and development of peptide therapeutics to use as understanding the basic concepts. Each chapter is written by experts from academia as well as industry. Rather than covering extensive literature, the book provides concepts of design, synthesis, delivery, as well as regulatory affairs and manufacturing of peptides in a systematic way with examples in each case. The book can be used as a reference for a pharmaceutical or biomedical scientist or graduate student who wants to pursue their career in peptide therapeutics. Some chapters will be written as a combination of basic principles and protocol so that scientists can adopt these methods to their research work. The examples provided can be used to perform peptide formulation considerations for the designed peptides. The book has nine chapters, and each chapter can be read as an independent unit on a particular concept.
| Author | : Henry I. Mosberg |
| Publisher | : MDPI |
| Total Pages | : 406 |
| Release | : 2020-03-13 |
| Genre | : Medical |
| ISBN | : 3039282883 |
Download Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery Book in PDF, ePub and Kindle
Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery is a book dedicated to Prof. Victor J. Hruby on the occasion of his 80th birthday. This book includes twenty contributions from authors representing diverse multidisciplinary fields of scientific expertise, and is focused on the extraordinary potential of peptides and peptidomimetics as a surging therapeutic modality and as tools for basic research and technology development.
| Author | : Michael L. Gross |
| Publisher | : John Wiley & Sons |
| Total Pages | : 484 |
| Release | : 2011-09-26 |
| Genre | : Medical |
| ISBN | : 1118116542 |
Download Protein and Peptide Mass Spectrometry in Drug Discovery Book in PDF, ePub and Kindle
The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discovery An instrumental analytical method for quantifying the mass and characterization of various samples from small molecules to large proteins, mass spectrometry (MS) has become one of the most widely used techniques for studying proteins and peptides over the last decade. Bringing together the work of experts in academia and industry, Protein and Peptide Mass Spectrometry in Drug Discovery highlights current analytical approaches, industry practices, and modern strategies for the characterization of both peptides and proteins in drug discovery. Illustrating the critical role MS technology plays in characterizing target proteins and protein products, the methods used, ion mobility, and the use of microwave radiation to speed proteolysis, the book also covers important emerging applications for neuroproteomics and antigenic peptides. Placing an emphasis on the pharmaceutical industry, the book stresses practice and applications, presenting real-world examples covering the most recent advances in mass spectrometry, and providing an invaluable resource for pharmaceutical scientists in industry and academia, analytical and bioanalytical chemists, and researchers in protein science and proteomics.
