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Paroxysmal Nocturnal Hemoglobinuria

Paroxysmal Nocturnal Hemoglobinuria
Author: Yuzuru Kanakura
Publisher: Springer
Total Pages: 358
Release: 2017-01-16
Genre: Medical
ISBN: 4431560033

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This volume reviews the fundamental understanding of this potentially life-threatening disease and the advances in treatment that have been achieved with the use of the monoclonal antibody eculizumab. Although the PIGA gene has been known for many years, the mechanism of clonal dominance in paroxysmal nocturnal hemoglobinuria is still largely unknown. This book, Paroxysmal Nocturnal Hemoglobinuria, discusses the direction of continuing research in this area, as well as the potential for the development of management guidelines. It serves as a valuable source of information for both basic scientists and physicians, especially immunologists targeting GPI-anchored proteins and complements, and hematologists specializing in bone marrow failure.


NORD Guide to Rare Disorders

NORD Guide to Rare Disorders
Author: National Organization for Rare Disorders
Publisher: Lippincott Williams & Wilkins
Total Pages: 982
Release: 2003
Genre: Medical
ISBN: 9780781730631

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NORD Guide to Rare Disorders is a comprehensive, practical, authoritative guide to the diagnosis and management of more than 800 rare diseases. The diseases are discussed in a uniform, easy-to-follow format--a brief description, signs and symptoms, etiology, related disorders, epidemiology, standard treatment, investigational treatment, resources, and references.The book includes a complete directory of orphan drugs, a full-color atlas of visual diagnostic signs, and a Master Resource List of support groups and helpful organizations. An index of symptoms and key words offers physicians valuable assistance in finding the information they need quickly.


Clinical Cytometry

Clinical Cytometry
Author: Michael Andreeff
Publisher:
Total Pages: 424
Release: 1986
Genre: Science
ISBN:

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PNH and the GPI-Linked Proteins

PNH and the GPI-Linked Proteins
Author: Neal S. Young
Publisher: Elsevier
Total Pages: 279
Release: 2000-04-28
Genre: Medical
ISBN: 9780080492094

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Paroxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctive biochemical and physical characteristics. Recently it has been acknowledged that PNH is not rare, and once sensitive assays--based on the chemistry of the proteins--can be applied to many patients. Written by international experts in the field, this book includes a number of distinctive characteristics, such as the clinical features of PNH, the mechanism of hemolysis, the biochemistry of glycosylphosphoinositol anchors, and the chemistry and biophysics of GPI-anchored proteins. This unique and timely volume will have a wide audience, including hematologists and oncologists with a clinical interest in this disease, as well as basic biochemists, immunologists, and cell biologists studying this class of proteins. Outlines the chemical features of PNH Explains the mechanism of hemolysis Includes work on the biochemistry of glycophosphoinositol anchors Contains descriptions of the chemistry and biophysics of GPI-anchored proteins


Congenital and Acquired Bone Marrow Failure

Congenital and Acquired Bone Marrow Failure
Author: Mahmoud Deeb Aljurf
Publisher: Elsevier
Total Pages: 274
Release: 2016-12-23
Genre: Science
ISBN: 0128041757

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Congenital and Acquired Bone Marrow Failure is a comprehensive guide to congenital and acquired bone marrow failure in adult and pediatric patients. Chapters are divided into two sections, acquired aplastic anemia and inherited bone marrow failure syndromes. Content ranges from the basic, to the translational, and from the epidemiology of acquired aplastic anemia and telomere biology, to the management, treatment, and supportive care of pediatric, adult, and geriatric patients. Contributors are world leading experts in the field of bone marrow failure. The book is required reading for residents, fellows, clinicians, and researchers across hematology, oncology, pathology, bone marrow transplantation, pediatrics, and internal medicine. Provides an overview of all congenital and acquired bone marrow failure syndromes Focuses on the molecular pathogenesis, clinical manifestation and diagnosis, laboratory features, and treatment of each disease within the syndromes Features the area of supportive care which is a topic of great interest to infectious disease physicians and those involved in transfusion services


Paroxysmal Nocturnal Hemoglobinuria and Related Disorders

Paroxysmal Nocturnal Hemoglobinuria and Related Disorders
Author: M. Omine
Publisher: Springer Science & Business Media
Total Pages: 376
Release: 2012-12-06
Genre: Medical
ISBN: 4431678670

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Few publications focus on the mysterious, genetically acquired disease paroxysmal nocturnal hemoglobinuria (PNH) and the related "intractable" disorders—aplastic anemia and myelodysplastic syndromes. Now, however, the latest understanding of the clinical and molecular genetic aspects of PNH is summarized here in the proceedings of the International Symposium held in Tokyo in 2001. Major topics reviewed include the molecular mechanisms of the PIG-A gene mutation; complement activation and inhibitors; experimental animal models; pathogenesis; the history of PNH research; the natural history of the disease; the mechanism of PNH clone expansion; the emergence of PNH clones under bone marrow failure syndromes; and treatment of the disease by immunosuppressive agents and stem cell transplantation. This book provides an invaluable summary of current research on the fundamental aspects of PNH pathology, presented by renowned experts in the field.


Hematology

Hematology
Author: Ronald Hoffman
Publisher:
Total Pages: 2821
Release: 2005
Genre: Blood
ISBN: 9780443066283

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The Saint-Chopra Guide to Inpatient Medicine

The Saint-Chopra Guide to Inpatient Medicine
Author: Sanjay Saint
Publisher: Oxford University Press, USA
Total Pages: 609
Release: 2018
Genre: Medical
ISBN: 0190862807

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Preceded by: Clinical clerkship in inpatient medicine / Sanjay Saint. 3rd ed. c2010.


Aplastic Anemia

Aplastic Anemia
Author: Hubert Schrezenmeier
Publisher: Cambridge University Press
Total Pages: 410
Release: 2000
Genre: Medical
ISBN: 9780521641012

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Comprehensive and up-to-date clinical reference, with an emphasis on treatment.


Handbook of Benign Hematology

Handbook of Benign Hematology
Author: Martha Pritchett Mims, MD, PhD
Publisher: Springer Publishing Company
Total Pages: 555
Release: 2019-12-11
Genre: Medical
ISBN: 0826149871

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Handbook of Benign Hematology is a practical guide to the diagnosis and management of benign hematologic conditions. The book begins with a chapter on normal hematopoiesis and follows with chapters devoted to groups of blood disorders and syndromes including neutrophil disorders, nonmalignant myeloid disorders, bone marrow failure syndromes, myeloproliferative disorders, anemias, iron metabolism disorders, platelet disorders, hemostasis and coagulation defects, and thrombosis. Each disorder subtype covered features a clinical case, an introduction to the condition, details on diagnosis including applicable criteria and lab work needed, key diagnostic dilemmas, prognosis, treatment options, details on clinical trials and emerging clinical strategies, and bulleted key points to highlight clinical pearls and common pitfalls. The final chapters provide best practices for transfusion medicine and a guide to pharmacologic agents and their uses in clinical practice for adult and pediatric patients. The handbook is filled with tables and illustrations which highlight FDA-approved drug information, clinical trials data, hematopathologic characteristics of different disorders, important management criteria and more, making it the ideal handbook for those in practice or for review. The Editors and chapter authors are experienced academic practitioners in the fields of adult and pediatric hematology, pathology, blood banking, and pharmacology. Emphasizing best practices for patient management, this handbook is essential for oncologists, hematologists, trainees, and other practitioners who regularly or increasingly receive referrals to diagnose and treat adults or children with nonmalignant hematologic conditions. Key Features: Includes dozens of clinical cases covering all nonmalignant blood disorders Emphasizes patient management and best practices for disorders seen in adults and children Contains over 30 color images and numerous tables for quick reference Presents important details of all pharmacologic agents used to treat or manage hematologic disorders and their complications Purchase includes access to the ebook for use on most mobile devices or computers