Paediatric Drug Optimization For Neglected Tropical Diseases PDF Download
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| Author | : World Health Organization |
| Publisher | : World Health Organization |
| Total Pages | : 56 |
| Release | : 2023-11-21 |
| Genre | : Business & Economics |
| ISBN | : 9240085173 |
Download Paediatric drug optimization for neglected tropical diseases Book in PDF, ePub and Kindle
Priority-setting is the first step to enable a targeted approach to research and development. Developing a prioritized drug portfolio of the most needed formulations for children is essential to streamline researchers’ and supplier’s efforts and resources around specific dosage forms and formulations that address most urgent needs for children. In general, due to limited financial incentives, few new drugs are being developed for Neglected Tropical Diseases (NTDs). Several NTDs disproportionately affect children compared to adults and, as is the case like for most diseases affecting adults and children, the burden to children is compounded by lack of inclusion of paediatric populations in clinical trials and/or lack of age-appropriate dosing regimens and formulations. The PADO-NTD exercise concluded with a final meeting organized in September 2023 with representatives from the four prioritized disease areas to reach consensus on a final PADO-NTD priority list, watch list and research questions and discuss transversal issues for the way forward. The meeting report will include summaries of the background, discussions and deliberations of all PADO exercises, and final conclusions and outputs of the overall PADO for NTD exercises.
| Author | : World Health Organization |
| Publisher | : World Health Organization |
| Total Pages | : 56 |
| Release | : 2024-05-30 |
| Genre | : Medical |
| ISBN | : 9240094822 |
Download Paediatric drug optimization for tuberculosis Book in PDF, ePub and Kindle
Paediatric drug optimization (PADO) exercises have been convened by the World Health Organization (WHO) for various diseases, demonstrating their potential and impact to accelerate access to optimal formulations in the context of fragmented small markets for medicines for children. The WHO Global Tuberculosis Programme has convened PADO-TB meetings since February 2019 (PADO-TB1), followed by an interim review of the PADO-TB1 priorities in September 2020. Optimization of paediatric TB medicines forms part of the key actions in the Roadmap towards ending TB in children and adolescents, third edition and contributes to the achievement of the targets for ending TB in children and adolescents set out at the second United Nations High-level Meeting on the Fight Against TB in 2023. Considering the latest WHO recommendations on drug-susceptible TB, drug-resistant TB and TB preventive treatment, recent developments in new TB medicines and formulations made available, results of clinical trials and studies, and advancements of key medicines in the TB R&D pipeline, WHO convened the second PADO-TB meeting (PADO-TB2) on 3–5 October 2023. This meeting report summarizes the proceedings, discussions and the main consensus-based outputs of the PADO-TB2 meeting: - PADO-TB2 priority list (priority formulations to be investigated/developed in the short term and essential formulations to be developed in the longer term) - PADO-TB2 watch list (promising candidates for investigation/development for children within 5–10 years) - Priority research questions.
| Author | : World Health Organization |
| Publisher | : World Health Organization |
| Total Pages | : 17 |
| Release | : 2022-11-30 |
| Genre | : Medical |
| ISBN | : 9240062041 |
Download First meeting of the WHO Strategic and Technical Advisory Group working group on access to safe, efficacious and quality-assured health products for neglected tropical diseases Book in PDF, ePub and Kindle
| Author | : World Health Organization |
| Publisher | : World Health Organization |
| Total Pages | : 16 |
| Release | : 2023-11-30 |
| Genre | : Medical |
| ISBN | : 9240083030 |
Download Second meeting of the WHO Strategic and Technical Advisory Group working group on access to safe, efficacious and quality-assured health products for neglected tropical diseases Book in PDF, ePub and Kindle
The STAG Working Group on access to safe, efficacious and quality-assured health products for neglected tropical diseases was established in 2021 to facilitate alignment of stakeholders on strategies and best practices for improving access to medicines and other health products for NTDs. The Working Group held its second technical meeting virtually on 19 September 2023. The main outcomes of the meeting were to expand the scope of drug efficacy monitoring to include other neglected tropical diseases and to seek synergy in addressing common issues and challenges across diseases for procurement and supply chain management. In addition to the Working Group’s members, observers, invited guests and the WHO secretariat attended the meeting. This publication contains the report of the meeting and its recommendations to STAG, which will be helpful as a reference and of use to the wider NTD community.
| Author | : |
| Publisher | : World Health Organization |
| Total Pages | : 72 |
| Release | : 2022-01-17 |
| Genre | : Family & Relationships |
| ISBN | : 9240041362 |
Download Working for a brighter, healthier future Book in PDF, ePub and Kindle
| Author | : World Health Organization |
| Publisher | : World Health Organization |
| Total Pages | : 31 |
| Release | : 2024-04-19 |
| Genre | : Business & Economics |
| ISBN | : 9240091270 |
Download Report of the Paediatric Regulatory Network meeting, 12-13 May 2022 Book in PDF, ePub and Kindle
The Paediatric Regulatory Network was initially created as a global paediatric working group in February 2010 in response to a recommendation from the 2008 International Conference on Drug Regulatory Authorities and as part of the World Health Organization (WHO) Better Medicines for Children Project in collaboration with the Bill & Melinda Gates Foundation, to offer a platform for discussion on paediatric regulatory considerations for national regulatory authorities. The Network was reactivated in December 2019 as a global paediatric network supporting the availability of quality-assured medical products for children, by facilitating communication, collaboration, training and regulatory harmonization across the development, registration and pharmacovigilance of paediatric medical products. The Network’s activities contribute efficiently to the implementation of World Health Assembly resolutions WHA60.20 (2007) on better medicines for children, WHA69.20 (2016) on promoting innovation and access to quality, safe, efficacious and affordable medicines for children, WHA67.20 (2014) on regulatory system strengthening for medical products and WHA67.22 (2014) on access to essential medicines.
| Author | : World Health Organization |
| Publisher | : World Health Organization |
| Total Pages | : 86 |
| Release | : 2024-05-04 |
| Genre | : Medical |
| ISBN | : 924009153X |
Download Global report on neglected tropical diseases 2024 Book in PDF, ePub and Kindle
This document is the second in a series of global reports describing progress towards the 2030 targets set in Ending the neglect to attain the Sustainable Development Goals: a road map for neglected tropical diseases 2021–2030. It describes a wide range of activities, accomplishments and challenges across the portfolio of NTDs and across all six WHO regions. The report presents epidemiological and programmatic data for 2022, which were gathered, compiled and analysed in 2023. In some cases, 2023 data are available and presented; in other cases, less recent information is included, when 2022 data are not available. In addition, it presents the main facts or events that occurred in 2023. In line with the road map’s companion document Ending the neglect to attain the Sustainable Development Goals: a framework for monitoring and evaluating progress of the road map for neglected tropical diseases 2021−2030, the report includes quantitative information on the status of the overarching, cross-cutting and disease-specific indicators. This is followed by qualitative information on each of the three road map pillars and on regional and country progress. The conclusions of the report and way forward are further complemented by annexes on cross-cutting indicator 6, status of donated medicines for treatment of NTDs, articles on NTDs published in the Weekly Epidemiological Record, target product profiles published as of 31 December 2023 and the list of global NTD reports published by WHO so far.
| Author | : World Health Organization |
| Publisher | : World Health Organization |
| Total Pages | : 56 |
| Release | : 2022-08-26 |
| Genre | : Medical |
| ISBN | : 9240056904 |
Download Shaping the global innovation and access landscape for better paediatric medicines Book in PDF, ePub and Kindle
| Author | : World Health Organization |
| Publisher | : World Health Organization |
| Total Pages | : 32 |
| Release | : 2019-09-02 |
| Genre | : Medical |
| ISBN | : 9241515341 |
Download Bench aids for the diagnosis of intestinal parasites Book in PDF, ePub and Kindle
This second edition of Bench aids for the diagnosis of intestinal parasites is intended both as a practical tool for the diagnosis of intestinal parasitic infections for laboratory and field workers and as a teaching aid for students and trainees. The plates are arranged on two sides: the recto with microphotographs for the identification of eggs larvae trophozoites cysts and oocysts occurring in faeces and the verso dedicated to the different copromicroscopical methods (procedures) and main staining techniques used in parasitology. Special attention has been devoted to all graphical and pictorial contents. The decision to include the outline of an Ascaris lumbricoides egg in its relative size next to each parasitic structure fulfils the intention of visualizing the actual dimensions that the eye needs to be looking for when examining the specimens with a microscope. For each image the size of the parasite and a short description are provided to assist in the microscopical identification. Two summary plates one for helminths and the other for protozoa are also included to provide a visual overview of the different presentations of parasitic elements. The bench aids have been produced in a weatherproof plastic-sealed format that is robust and easy to use at the bench. They are recommended for use by all health workers engaged in the routine diagnosis of intestinal parasitic infections.
| Author | : World Health Organization |
| Publisher | : World Health Organization |
| Total Pages | : 25 |
| Release | : 2024-02-19 |
| Genre | : Medical |
| ISBN | : 9240086021 |
Download Tenth meeting of the Working Group on Monitoring of Neglected Tropical Diseases Drug Efficacy, Ghent, 21 June 2023 Book in PDF, ePub and Kindle
Helminth control programmes based on preventive chemotherapy against soil?transmitted helminthiases and schistosomiasis are continuing to scale up. In 2021, the global coverage of preventive chemotherapy reached 62.2% for soil-transmitted helminthiases and 40.3% for schistosomiasis; more than 650 million individuals were treated with albendazole and mebendazole for soil-transmitted helminthiases and with praziquantel for schistosomiasis. The expansion of preventive chemotherapy can potentially risk triggering anthelminthic drug resistance and put at stake the long-term public health benefits of the intervention. Antimicrobial resistance is not yet a public health problem in human helminthiases, as opposed to helminths of veterinary importance. The Working Group on Monitoring of Neglected Tropical Diseases Drug Efficacy (“the Working Group”) was established by the World Health Organization (WHO) in 2011 with the purpose of promoting: - the establishment of a standard system for monitoring drug efficacy; - the judicious use of anthelminthics in order to sustain their efficacy and delay antimicrobial resistance; and - the testing of alternative drugs and drug combinations, should antimicrobial resistance emerge for the front-line drugs presently used in preventive chemotherapy programmes. The tenth meeting of the Working Group was held at Ghent University (Ghent, Belgium) on 21 June 2023. The meeting was chaired by Professor Jozef Vercruysse (Ghent University). The rapporteurs were Dr Bruno Levecke (Ghent University) and Dr Denise Mupfasoni (WHO Global Neglected Tropical Diseases Programme). The objectives of the meeting were: - to review the data on monitoring the efficacy of anthelminthics currently used in large-scale deworming programmes for soil-transmitted helminthiases and schistosomiasis; - to review the need for, and recommend the revision of, the WHO guidance on monitoring drug efficacy in large-scale deworming programmes; and - to review ongoing research on anthelminthic drugs (combinations).
