Optical Coherence Tomography In Multiple Sclerosis PDF Download
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Author | : Axel Petzold |
Publisher | : Springer |
Total Pages | : 203 |
Release | : 2015-08-28 |
Genre | : Medical |
ISBN | : 3319209701 |
Download Optical Coherence Tomography in Multiple Sclerosis Book in PDF, ePub and Kindle
This book gives a clinical context to optical coherence tomography (OCT) findings, while considering the differential diagnosis and providing patient management guidance. Relevant anatomical and technical aspects are discussed, followed by a pragmatic illustration of the use of OCT for the clinical spectrum of multiple sclerosis and optic neuritis, and finishing with information on monitoring ocular side effects of recently approved disease-modifying treatments in multiple sclerosis. Optical Coherence Tomography in Multiple Sclerosis: Clinical Applications is aimed at clinical neurologists working with patients suffering from MS and general neurologists who see patients with visual symptoms in their daily practice. Ophthalmologists sharing clinical responsibilities with neurologists for patients under disease-modifying treatments will also find the book of interest.
Author | : Peter A. Calabresi |
Publisher | : Cambridge University Press |
Total Pages | : 235 |
Release | : 2015-05-14 |
Genre | : Medical |
ISBN | : 1107041309 |
Download Optical Coherence Tomography in Neurologic Diseases Book in PDF, ePub and Kindle
The first comprehensive review of the use of optical coherence tomography in neurological diseases for neurologists, neuro-ophthalmologists, and neuroradiologists.
Author | : |
Publisher | : |
Total Pages | : 0 |
Release | : 2021 |
Genre | : |
ISBN | : 9789464168723 |
Download Optical Coherence Tomography in Multiple Sclerosis Book in PDF, ePub and Kindle
Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) affecting more than two million people worldwide. The disease is characterised by inflammation in the CNS (leading to episodes of focal neurological dysfunction, i.e. relapses) and neurodegeneration (leading to progressive and permanent disability). Depending on the localisation of the CNS damage, patients exhibit a wide range of symptoms including muscle weakness, sensory disturbances, problems with coordination, fatigue and cognitive impairment. Visual symptoms are common as well, with more dan 50% of MS patients experiencing one or more episodes of optic neuritis (ON) during the course of the disease. The disease course in MS is highly variable and difficult to predict. However, predicting the disease course is crucial for determining the proper treatment. This thesis focuses on how optical coherence tomography (OCT) can aid in monitoring and predicting the disease course in patients with MS. OCT is an imaging technique that generates high resolution images of the retina and all its layers. The inner two retinal layers consist of the retinal ganglion cells and their axons that will eventually form the optic nerve. Thereby, these two layers are directly connected to the brain. Previous research has demonstrated that previous episodes of ON result in atrophy (thinning) of these two layers. Sometimes, it can be challenging to establish whether a patient has ever experienced an episode of optic neuritis clinically. The absolute thickness of the retinal layers is not a good indicator for this. Our research shows that the difference in retinal layer thickness between the eyes of a single patient can, with high accuracy, discriminate ON patients from non-ON patients. Being able to establish the presence of a previous episode of ON in this way, might lead to an earlier diagnosis of MS and earlier treatment.
Author | : |
Publisher | : |
Total Pages | : 560 |
Release | : 2020 |
Genre | : Central nervous system |
ISBN | : 9783030262709 |
Download OCT and Imaging in Central Nervous System Diseases Book in PDF, ePub and Kindle
The second edition of OCT and Imaging in Central Nervous System Diseases offers updated state-of-the-art advances using optical coherence tomography (OCT) regrading neuronal loss within the retina. Detailed information on the OCT imaging and interpretation is provided for the evaluation of disease progression in numerous neurodegenerative disorders and as a biological marker of neuroaxonal injury. Covering disorders like multiple sclerosis, Parkinson's disease, Alzheimer's disease, intracranial hypertension, Friedreich's ataxia, schizophrenia, hereditary optic neuropathies, glaucoma, and amblyopia, readers will given insights into effects on the retina and the and optic nerve. Individual chapters are also devoted to OCT technique, new OCT technology in neuro-ophthalmology, OCT and pharmacological treatment, and the use of OCT in animal models. Similar to the first edition, this book is an excellent and richly illustrated reference for diagnosis of many retinal diseases and monitoring of surgical and medical treatment. OCT allows to study vision from of the retina to the optic tracts. Retinal axons in the retinal nerve fiber layer (RNFL) are non-myelinated until they penetrate the lamina cribrosa. Hence, the RNFL is an ideal structure for visualization of any process of neurodegeneration, neuroprotection, or regeneration. By documenting the ability of OCT to provide key information on CNS diseases, this book illustrates convincingly that the eye is indeed the "window to the brain".
Author | : Bilyana Mihaylova |
Publisher | : |
Total Pages | : 0 |
Release | : 2019 |
Genre | : Electronic books |
ISBN | : |
Download Optical Coherence Tomography (OCT) and Angio-OCT Imaging Techniques in Multiple Sclerosis Patients with Or Without Optic Neuritis Book in PDF, ePub and Kindle
The visual system is typically affected in multiple sclerosis (MS) patients. The most common ocular manifestation during the clinical course of the disease is optic neuritis (ON). Optical coherence tomography (OCT) is well-established tool for biomedical imaging that enables detection of retinal nerve fiber layer and ganglion cell layer thickness reduction ,Äì biomarkers of axonal damage and neuronal loss in MS. And OCT angiography (angio-OCT) is another imaging method for assessing retinal and choroidal vessels with no need of contrast dye injection. In our prospective study, we investigate parafoveal and peripapillary microvascular retinal networks in 18 MS patients (35 eyes) through angio-OCT (AngioVue, OptoVue). According to our results, early structural changes in MS patients without previous history of acute ON episode are unable to be detected. As a follow-up imaging technique, OCT is very useful for changes in axonal thickness and defines the progression rate of the disease. Angio-OCT vis-√†-vis OCT investigation detects the ocular perfusion reduction before the appearance of structural changes. From all investigated structural and density parameters only those in superficial capillary plexus show significant changes in MS patients without ON. For accurate diagnostic and following-up process, both structural and vascular parameters need to be assessed in MS patients.
Author | : Josef F. Bille |
Publisher | : Springer |
Total Pages | : 407 |
Release | : 2019-08-13 |
Genre | : Medical |
ISBN | : 3030166384 |
Download High Resolution Imaging in Microscopy and Ophthalmology Book in PDF, ePub and Kindle
This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
Author | : Wolfgang Drexler |
Publisher | : Springer Science & Business Media |
Total Pages | : 1346 |
Release | : 2008-12-10 |
Genre | : Medical |
ISBN | : 3540775501 |
Download Optical Coherence Tomography Book in PDF, ePub and Kindle
Optical coherence tomography (OCT) is the optical analog of ultrasound imaging and is emerging as a powerful imaging technique that enables non-invasive, in vivo, high resolution, cross-sectional imaging in biological tissue. This book introduces OCT technology and applications not only from an optical and technological viewpoint, but also from biomedical and clinical perspectives. The chapters are written by leading research groups, in a style comprehensible to a broad audience.
Author | : |
Publisher | : Academic Press |
Total Pages | : 759 |
Release | : 2007-06-07 |
Genre | : Science |
ISBN | : 0080544274 |
Download The Neurobiology of Multiple Sclerosis Book in PDF, ePub and Kindle
Multiple sclerosis (MS) is an immune-mediated neurodegenerative disorder of the human central nervous system (CNS) which usually affects young adults with certain genetic backgrounds who are then exposed to certain precipitating environmental antigen(s). Despite major advances of the past two decades in understanding the pathophysiology of MS, and in spite of the introduction of new immunomodulatory and immuno-suppressive agents which may slow down disease progression and delay the onset of disability, the “cause and the “cure for MS remain elusive. This volume of International Review of Neurobiology focuses on MS and related disorders. The volume can be divided into various sections with the main emphasis on MS pathogenesis, clinical features and epidemiology, neuroimaging, and treatment. The ultimate goal of this book is to encourage further research into the pathogenesis of this elusive disease.
Author | : |
Publisher | : |
Total Pages | : |
Release | : 2014 |
Genre | : |
ISBN | : |
Download Optische Kohärenztomographie zeigt bei Neuromyelitis Optica und Multipler Sklerose deutliche Unterschiede in der Netzhautschädigung auf Book in PDF, ePub and Kindle
Author | : Jonathan Micieli |
Publisher | : |
Total Pages | : 536 |
Release | : 2019-06-18 |
Genre | : |
ISBN | : 9781074839628 |
Download Case-Based Neuro-Ophthalmology Book in PDF, ePub and Kindle
Case-Based Neuro-Ophthalmology is designed for ophthalmology and neurology residents learning neuro-ophthalmology. Multiple choice questions are a common way of assessing knowledge on standardized examinations, but are also a useful way to learn. This book aims to familiarize the reader with common neuro-ophthalmology case presentations and poses questions that must be considered before arriving at a coherent impression and plan. Common test questions are also included to help with preparation for standardized examinations.Key Features:- Neuroimaging review tailored to ophthalmology residents for high-yield topics and images relevant to neuro-ophthalmology- Optical coherence tomography chapter dedicated to high-yield topics for neurology and ophthalmology residents- 23 of the most common neuro-ophthalmology cases ranging from optic neuritis, ischemic optic neuropathy and 6th nerve palsy with a complete set of multiple choice questions, answers and explanations. - Clinical pearls are highlighted in Clinical Pearl boxes for the most high yield information