Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 431 In Vitro Skin Corrosion Reconstructed Human Epidermis Rhe Test Method PDF Download
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Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 29 |
Release | : 2019-06-18 |
Genre | : |
ISBN | : 9264264612 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method Book in PDF, ePub and Kindle
The test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight of evidence determination using other existing information.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 34 |
Release | : 2013-07-26 |
Genre | : |
ISBN | : 9264203826 |
Download Test No. 431: In Vitro Skin Corrosion: Reconstructed Human Epidermis (RHE) Test Method Book in PDF, ePub and Kindle
The present Test Guideline addresses the human health hazard endpoint skin corrosion, following exposure to a test chemical. Skin corrosion is defined as the production of irreversible tissue damage, manifested as visible necrosis of the skin ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 28 |
Release | : 2021-06-17 |
Genre | : |
ISBN | : 9264242848 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method Book in PDF, ePub and Kindle
This Test Guideline describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 8 |
Release | : 2004-11-23 |
Genre | : |
ISBN | : 9264071148 |
Download Test No. 431: In Vitro Skin Corrosion: Human Skin Model Test Book in PDF, ePub and Kindle
The test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight of evidence determination using ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 28 |
Release | : 2023-07-04 |
Genre | : |
ISBN | : 9264353089 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 498: In vitro Phototoxicity - Reconstructed Human Epidermis Phototoxicity test method Book in PDF, ePub and Kindle
Skin phototoxicity (photoirritation) is defined as an acute toxic response elicited by topically or systemically administered photoreactive chemicals after the exposure of the skin to environmental light. The in vitro reconstructed human epidermis phototoxicity test (RhE PT) is used to identify the phototoxic potential of a test chemical after topical application in reconstructed human epidermis (RhE) tissues in the presence and absence of simulated sunlight.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 18 |
Release | : 2010-07-23 |
Genre | : |
ISBN | : 9264090959 |
Download Test No. 439: In Vitro Skin Irritation Reconstructed Human Epidermis Test Method Book in PDF, ePub and Kindle
This Test Guideline describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2 ...
Author | : Organisation de coopération et de développement économiques |
Publisher | : |
Total Pages | : 26 |
Release | : 2015 |
Genre | : |
ISBN | : |
Download Test No. 431: In Vitro Skin Corrosion: Reconstructed Human Epidermis (RHE) Test Method Book in PDF, ePub and Kindle
The test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight of evidence determination using other existing information. The test protocol may also provide an indication of the distinction between severe and less severe skin corrosives. This Test Guideline does not require the use of live animals or animal tissue for the assessment of skin corrosivity. The test material (solid or liquid) is applied uniformly and topically to a three-dimensional human skin model, comprising at least a reconstructed epidermis with a functional stratum corneum. Two tissue replicates are used for each treatment (exposure time), and for controls. Corrosive materials are identified by their ability to produce a decrease in cell viability below defined threshold levels at specified exposure periods. Coloured chemicals can also be tested by used of an HPLC procedure. The principle of the human skin model assay is based on the hypothesis that corrosive chemicals are able to penetrate the stratum corneum by diffusion or erosion, and are cytotoxic to the underlying cell layers.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 15 |
Release | : 2015-07-28 |
Genre | : |
ISBN | : 9264242732 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 430: In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method (TER) Book in PDF, ePub and Kindle
This Test Guideline addresses the human health endpoint skin corrosion. It is based on the rat skin transcutaneous electrical resistance (TER) test method, which utilizes skin discs to identify corrosives by their ability to produce a loss of normal stratum corneum integrity and barrier function.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 13 |
Release | : 2015-07-28 |
Genre | : |
ISBN | : 9264242791 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 435: In Vitro Membrane Barrier Test Method for Skin Corrosion Book in PDF, ePub and Kindle
This updated Test Guideline 435 provides an in vitro membrane barrier test method that can be used to identify corrosive chemicals. The test method utilizes an artificial membrane designed to respond to corrosive chemicals in a manner similar to animal skin in situ.
Author | : |
Publisher | : |
Total Pages | : |
Release | : 2013 |
Genre | : |
ISBN | : |
Download Test No. 431 Book in PDF, ePub and Kindle