Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 427 Skin Absorption In Vivo Method PDF Download
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Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 8 |
Release | : 2004-11-23 |
Genre | : |
ISBN | : 9264071067 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 427: Skin Absorption: In Vivo Method Book in PDF, ePub and Kindle
The in vivo percutaneous absorption study set out in this Test Guideline provides the linkage necessary to extrapolate from oral studies when making safety assessments following dermal exposure. The in vivo method, described in this guideline ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 8 |
Release | : 2004-11-23 |
Genre | : |
ISBN | : 9264071083 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 428: Skin Absorption: In Vitro Method Book in PDF, ePub and Kindle
This Test method has been designed to provide information on absorption of a test substance, (ideally radiolabelled), applied to the surface of a skin sample separating the two chambers (a donor chamber and a receptor chamber) of a diffusion cell ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 31 |
Release | : 2004-11-01 |
Genre | : |
ISBN | : 9264078797 |
Download OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Document for the Conduct of Skin Absorption Studies Book in PDF, ePub and Kindle
This guidance document has been prepared to support technical aspects of the OECD skin absorption test guidelines. In particular is discusses the various aspects of in vivo vs. in vitro testing.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 28 |
Release | : 2021-06-17 |
Genre | : |
ISBN | : 9264242848 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method Book in PDF, ePub and Kindle
This Test Guideline describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 63 |
Release | : 2015-02-05 |
Genre | : |
ISBN | : 9264229701 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 442C: In Chemico Skin Sensitisation Assays addressing the Adverse Outcome Pathway key event on covalent binding to proteins Book in PDF, ePub and Kindle
This Test Guideline addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. It provides an in chemico procedure (Direct Peptide Reactivity Assay – DPRA) used for supporting the discrimination between skin sensitisers and non-sensitisers.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 13 |
Release | : 2017-10-09 |
Genre | : |
ISBN | : 9264070583 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 402: Acute Dermal Toxicity Book in PDF, ePub and Kindle
This method provides information on health hazard likely to arise from a short-term exposure to solid or liquid test substance by the dermal route. This Test Guideline is intended primarily for use with rodents (rat, rabbit or guinea pig may be ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 67 |
Release | : 2018-06-27 |
Genre | : |
ISBN | : 9264229825 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 442D: In Vitro Skin Sensitisation Assays addressing the Adverse Outcome Pathway Key Event on Keratinocyte activation Book in PDF, ePub and Kindle
This Test Guideline (TG) provides an in vitro procedure (the ARE-Nrf2 luciferase test method) used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 28 |
Release | : 2023-07-04 |
Genre | : |
ISBN | : 9264353089 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 498: In vitro Phototoxicity - Reconstructed Human Epidermis Phototoxicity test method Book in PDF, ePub and Kindle
Skin phototoxicity (photoirritation) is defined as an acute toxic response elicited by topically or systemically administered photoreactive chemicals after the exposure of the skin to environmental light. The in vitro reconstructed human epidermis phototoxicity test (RhE PT) is used to identify the phototoxic potential of a test chemical after topical application in reconstructed human epidermis (RhE) tissues in the presence and absence of simulated sunlight.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 8 |
Release | : 1981-05-12 |
Genre | : |
ISBN | : 9264070745 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 410: Repeated Dose Dermal Toxicity: 21/28-day Study Book in PDF, ePub and Kindle
This study relates to the analysis, via dermal application, of the health hazard of solid or liquid test substance. This method is composed of two tests: the main test and the limit test. This Test Guideline is intended for use with the adult rat ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 53 |
Release | : 2023-07-04 |
Genre | : |
ISBN | : 9264903003 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Guideline No. 497: Defined Approaches on Skin Sensitisation Book in PDF, ePub and Kindle
A Defined Approach (DA) consists of a selection of information sources (e.g in silico predictions, in chemico, in vitro data) used in a specific combination, and resulting data are interpreted using a fixed data interpretation procedure (DIP) (e.g. a mathematical, rule-based model). DAs use methods in combination and are intended to overcome some limitations of the individual, stand-alone methods.