Novel Cancer Treatments Based On Autophagy Modulation PDF Download
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Author | : Marco Cordani |
Publisher | : Frontiers Media SA |
Total Pages | : 236 |
Release | : 2021-06-11 |
Genre | : Science |
ISBN | : 2889668738 |
Download Novel Cancer Treatments based on Autophagy Modulation Book in PDF, ePub and Kindle
Author | : Sujit Kumar Bhutia |
Publisher | : Springer Nature |
Total Pages | : 284 |
Release | : 2020-10-24 |
Genre | : Medical |
ISBN | : 9811569304 |
Download Autophagy in tumor and tumor microenvironment Book in PDF, ePub and Kindle
This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.
Author | : Jin-Ming Yang |
Publisher | : Springer |
Total Pages | : 146 |
Release | : 2016-09-02 |
Genre | : Medical |
ISBN | : 3319427407 |
Download Targeting Autophagy in Cancer Therapy Book in PDF, ePub and Kindle
This volume will detail the current state and perspectives of autophagy-based cancer therapy. Covering a wide range of topics, it will include an overview of autophagy as a therapeutic target in cancer, autophagy modulators as cancer therapeutic agents, implications of micro-RNA-regulated autophagy in cancer therapy, modulation of autophagy through targeting PI3 kinase in cancer therapy, targeting autophagy in cancer stem cells, and roles of autophagy in cancer immunotherapy. In addition, the volume will review applications of system biology and bioinformatics approaches to discovering cancer therapeutic targets in the autophagy regulatory network. The volume will be beneficial for a variety of basic and clinical scientists, including cancer biologists, autophagy researchers, pharmacologists, and clinical oncologists who wish to delve more deeply into this field of cancer research. This volume will be the first book to focus solely on autophagy as a target in cancer therapy. As well, it will comprehensively discuss the roles of autophagy in most currently available cancer treatments.
Author | : Patrizia Agostinis |
Publisher | : Frontiers Media SA |
Total Pages | : 111 |
Release | : 2018-02-19 |
Genre | : |
ISBN | : 2889454223 |
Download Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy Book in PDF, ePub and Kindle
Macroautophagy, the major lysosomal pathway for recycling intracellular components including whole organelles, has emerged as a key process modulating tumorigenesis, tumor–stroma interactions, and cancer therapy. An impressive number of studies over the past decade have unraveled the plastic role of autophagy during tumor development and dissemination. The discoveries that autophagy may either support or repress neoplastic growth and contextually favor or weaken resistance and impact antitumor immunity have spurred efforts from many laboratories trying to conceptualize the complex role of autophagy in cancer using cellular and preclinical models. This complexity is further accentuated by recent findings highlighting that various autophagy-related genes have roles beyond this catabolic mechanism and interface with oncogenic pathways, other trafficking and degradation mechanisms and the cell death machinery. From a therapeutic perspective, knowledge of how autophagy modulates the tumor microenvironment is crucial to devise autophagy-targeting strategies using smart combination of drugs or anticancer modalities. This eBook contains a collection of reviews by autophagy researchers and provides a background to the state-of-the-art in the field of autophagy in cancer, focusing on various aspects of autophagy regulation ranging from its molecular components to its cell autonomous role, e.g. in cell division and oncogenesis, miRNAs regulation, cross-talk with cell death pathways as well as cell non-autonomous role, e.g. in secretion, interface with tumor stroma and clinical prospects of autophagy-based biomarkers and autophagy modulators in anticancer therapy. This eBook is part of the TransAutophagy initiative to better understand the clinical implications of autophagy in cancer.
Author | : Hong-Gang Wang |
Publisher | : Springer Science & Business Media |
Total Pages | : 267 |
Release | : 2013-03-30 |
Genre | : Medical |
ISBN | : 1461465613 |
Download Autophagy and Cancer Book in PDF, ePub and Kindle
With the explosion of information on autophagy in cancer, this is an opportune time to speed the efforts to translate our current knowledge about autophagy regulation into better understanding of its role in cancer. This book will cover the latest advances in this area from the basics, such as the molecular machinery for autophagy induction and regulation, up to the current areas of interest such as modulation of autophagy and drug discovery for cancer prevention and treatment. The text will include an explanation on how autophagy can function in both oncogenesis and tumor suppression and a description of its function in tumor development and tumor suppression through its roles in cell survival, cell death, cell growth as well as its influences on inflammation, immunity, DNA damage, oxidative stress, tumor microenvironment, etc. The remaining chapters will cover topics on autophagy and cancer therapy. These pages will serve as a description on how the pro-survival function of autophagy may help cancer cells resist chemotherapy and radiation treatment as well as how the pro-death functions of autophagy may enhance cell death in response to cancer therapy, and how to target autophagy for cancer prevention and therapy − what to target and how to target it.
Author | : Marco Cordani |
Publisher | : Frontiers Media SA |
Total Pages | : 164 |
Release | : 2023-06-29 |
Genre | : Medical |
ISBN | : 2832527620 |
Download Autophagy Modulation in Cancer Treatment Utilizing Nanomaterials and Nanocarriers Book in PDF, ePub and Kindle
Author | : |
Publisher | : Academic Press |
Total Pages | : 384 |
Release | : 2021-04-13 |
Genre | : Medical |
ISBN | : 0128241594 |
Download Autophagy and Senescence in Cancer Therapy Book in PDF, ePub and Kindle
Advances in Cancer Research, Volume 150, the latest release in this ongoing series, covers the relationship(s) between autophagy and senescence, how they are defined, and the influence of these cellular responses on tumor dormancy and disease recurrence. Specific sections in this new release include Autophagy and senescence, converging roles in pathophysiology, Cellular senescence and tumor promotion: role of the unfolded protein response, autophagy and senescence in cancer stem cells, Targeting the stress support network regulated by autophagy and senescence for cancer treatment, Autophagy and PTEN in DNA damage-induced senescence, mTOR as a senescence manipulation target: A forked road, and more. Addresses the relationship between autophagy and senescence in cancer therapy Covers autophagy and senescence in tumor dormancy Explores autophagy and senescence in disease recurrence
Author | : Xi Chen |
Publisher | : Elsevier Inc. Chapters |
Total Pages | : 19 |
Release | : 2013-09-03 |
Genre | : Medical |
ISBN | : 0128069457 |
Download Autophagy Book in PDF, ePub and Kindle
Autophagy is involved in the resistance against anticancer treatment. Both autophagy inhibitors and inducers have been demonstrated to be effective in enhancing the effect of chemotherapy and irradiation in various anticancer regimes. Currently, autophagy inhibitors are being examined in clinical trials as an adjuvant for traditional therapies. However, caution must be exercised, considering the complexity of autophagy regulation in tumorigenesis and in development of therapeutic resistance. There is also evidence suggesting that targeting autophagy may not have the desired effects. We have found that cancer cells with long-term autophagy deficiency can evade the dependence on autophagy to survive. Furthermore, some tumors are intrinsically insensitive to autophagy manipulation. Although regulation of autophagy is a promising new addition to cancer therapy, careful evaluations must be exercised when applying this strategy in clinical practice on individual bases.
Author | : Salem Chouaib |
Publisher | : Academic Press |
Total Pages | : 242 |
Release | : 2020-05-25 |
Genre | : Science |
ISBN | : 0128196092 |
Download Autophagy in Immune Response: Impact on Cancer Immunotherapy Book in PDF, ePub and Kindle
Autophagy in Immune Response: Impact on Cancer Immunotherapy focuses on the status and future directions of autophagy with respect to different aspects of its interaction with the immune system and immunotherapy. The book takes scientific research in autophagy a step further by presenting reputable information on the topic and offering integrated content with advancements in autophagy, from cell biology and biochemical research, to clinical treatments. This book is a valuable source for cancer researchers, oncologists, graduate students and several members of biomedical field who are interested in learning more on the relationship between autophagy and immunotherapies. Presents updated knowledge on autophagy at the basic level and its potential use in cancer treatment Offers the first book to cover autophagy at the interface of cell biology, immunology and tumor biology Provides a wealth of information on the topic in a coherent and comprehensive collection of contributions by world renowned scientists and investigators
Author | : Liliya Tyutyunyk-Massey |
Publisher | : |
Total Pages | : |
Release | : 2019 |
Genre | : |
ISBN | : |
Download Modulation of Autophagy and Senescence to Enhance the Response to Therapy in Triple Negative Breast Cancer Book in PDF, ePub and Kindle
Abstract Although great strides have been made over the decades in development and optimization of anti-cancer therapies, even highly effective drugs often fail to completely eliminate tumors. Residual tumor cells can enter into a state of dormancy for prolonged periods of time but eventually are able to regain proliferative capacity and reemerge as chemotherapy-resistant disease. Because recurrent disease is a leading contributor to patient's mortality, it is paramount to identify strategies for effectively destroying residual tumor cells. Cytotoxic drugs and ionizing radiation are used as standard therapies in a variety of cancers. These modalities induce apoptosis, autophagy and senescence. Senescence is a state of prolonged growth arrest, which cells are able to eventually escape regaining proliferative capacity. Autophagy is generally considered to be a protective mechanism; however, it can take non-protective or even cytotoxic form in response to anti-cancer treatments. Furthermore, chemotherapy or radiation induced autophagy was shown to be a contributor to the immune response against tumor cells. Using a model of Triple Negative Breast Cancer, we were able to show increased immunosurveillance of tumor cells after enhanced autophagy was achieved by combining epigenetic remodeling with chemotherapy. Alternatively, we were able to achieved effective clearance of tumor cells induced into senescence by chemotherapy or radiation by the senolytic drug ABT-263 (Navitoclax). In summary, autophagy and senescence alone or in concert, can be induced by conventional anti-tumor modalities. Those processes can be modulated independently to achieve clearance of residual tumor cells following anti-cancer therapies.