Norms Standards And Processes Underpinning Development Of Who Recommendations On Vector Control PDF Download

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Norms, standards and processes underpinning development of WHO recommendations on vector control

Norms, standards and processes underpinning development of WHO recommendations on vector control
Author: World Health Organization
Publisher: World Health Organization
Total Pages: 32
Release: 2020-12-23
Genre: Medical
ISBN: 9240017380

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Vector-borne diseases (VBDs) result in high levels of morbidity and mortality, and disproportionately affect some of the world’s poorest populations. However, there are currently few effective tools to combat transmission of vector-borne pathogens, making the development of new tools and strategies of paramount importance. For WHO to recommend a novel tool or strategy for use by governments and public health agencies, WHO must be certain that these interventions demonstrate public health value against their target disease(s). Furthermore, the interventions need to be safe, of high quality in their production and/or manufacturing, and efficacious against the target vectors. This document outlines the evaluation process that WHO’s undertakes to assess novel tools and strategies targeted at VBDs. Its aim is to articulate the linkage between the generation of evidence that demonstrates public health impact of novel interventions, and the development of recommendations based on the generated data. The document defines standards for the evaluation process, as well as the steps that an applicant needs to undertake, along with some guiding principles that aim to support applicants in the development of submissions with WHO.


Twentieth meeting of the WHO Vector Control Advisory Group

Twentieth meeting of the WHO Vector Control Advisory Group
Author: World Health Organization
Publisher: World Health Organization
Total Pages: 30
Release: 2024-06-28
Genre: Medical
ISBN: 9240096671

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On 4, 5 and 7 March 2024, the WHO Malaria Policy Advisory Group (MPAG) convened in Yaoundé, Cameroon, to review updates and progress, and to provide guidance on thematic areas of work by the Global Malaria Programme. The meeting focused on the following topics: malaria vaccine introduction and scale-up, and the Gavi-supported malaria learning agenda; the High burden to high impact (HBHI) approach; subnational tailoring; biological threats to vector control in Africa; the strategy to respond to antimalarial drug resistance in Africa; the development of guidelines recommendations on tafenoquine, primaquine and near-patient glucose-6-phosphate dehydrogenase (G6PD) diagnostic tests to support radical cure of Plasmodium vivax; and malaria elimination, including zoonotic malaria.


Data requirements and protocol for determining comparative efficacy of vector control products

Data requirements and protocol for determining comparative efficacy of vector control products
Author: World Health Organization
Publisher: World Health Organization
Total Pages: 36
Release: 2024-05-16
Genre: Medical
ISBN: 9240092749

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The aim of this protocol is to support the conduct of entomological comparative efficacy assessments for vector control products and the associated non-inferiority analysis. This evidence is used to inform discussions within the guidelines development context as to whether a new vector control product should be considered as covered by one or more existing WHO recommendations or not. Alternatively, the evidence may inform the extension of an existing WHO recommendation or the development of a new one, provided that non-inferiority is demonstrated.


Evidence generation for development of health products

Evidence generation for development of health products
Author: World Health Organization
Publisher: World Health Organization
Total Pages: 40
Release: 2023-12-15
Genre: Medical
ISBN: 9240084290

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This document describes the main elements that World Health Organization (WHO) technical departments should elaborate on when providing guidance on evidence generation to research and development (R&D) specialists who are developing health products to address critical unmet needs in public health. While WHO’s TPPs, preferred product characteristics (PPCs) and target regimen profiles (TRPs) provide high-level information on the desired characteristics of the product, the target population, and the key endpoints for safety and efficacy evaluation, more detailed guidance is needed to enable the development of suitable trial/study designs aimed at producing relevant evidence for WHO’s normative products such as guidelines. The objective of the Guidance for evidence generation (GEG) process is to produce a guidance document on how best to perform studies for the development of novel products (diagnostics, drugs, vaccines, vector control) and thus how to enable the generation of robust data and evidence to inform a WHO evidence review process.


Technical consultation on determining non-inferiority of vector control products within an established class

Technical consultation on determining non-inferiority of vector control products within an established class
Author:
Publisher: World Health Organization
Total Pages: 30
Release: 2021-11-24
Genre: Medical
ISBN: 9240038019

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This meeting report describes the discussion and outcomes of the technical consultation on the value of non-inferiority assessments within the vector control evaluation process, for interventions that fall within an established intervention class. The discussion was based on pilot trials assessing non-inferiority of pyrethroid-PBO nets against malaria. Objectives of the meeting included determining the value, and challenges associated with using non-inferiority assessments and considerations of how these evaluations could be implemented within the existing framework of the WHO vector control evaluation process.