New Horizons In Predictive Toxicology PDF Download
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Author | : Alan G. E. Wilson |
Publisher | : Royal Society of Chemistry |
Total Pages | : 711 |
Release | : 2012 |
Genre | : Medical |
ISBN | : 1849730512 |
Download New Horizons in Predictive Toxicology Book in PDF, ePub and Kindle
The sophistication of modelling and simulation technologies have improved dramatically over the past decade and their applications in toxicity prediction and risk assessment are of critical importance. The integration of predictive toxicology approaches will become increasingly necessary as industrial chemicals advance and as new pharmaceuticals enter the market. In this comprehensive discussion of predictive toxicology and its applications, leading experts express their views on the technologies currently available and the potential for future developments. The book covers a wide range of topics including in silico, in vitro and in vivo approaches that are being used in the safety assessment of chemical substances. It reflects the growing and urgent need to strengthen and improve our ability to predict the safety and risks posed by industrial and pharmaceutical chemicals in humans. The reader will find extensive information on the use of current animal models used for various toxicities and target mediated toxicities. Also discussed are the recent regulatory initiatives to improve the safety assessment of chemicals. The book provides an expert and comprehensive discussion on the current status and future directions of predictive toxicology and its application. The various chapters in the book also reflect the growing need for improvements in our technologies and abilities to predict toxicities of pharmaceutical and industrial chemicals to ensure product safety and protect public health.
Author | : Alan G E Wilson |
Publisher | : Royal Society of Chemistry |
Total Pages | : 444 |
Release | : 2015-11-20 |
Genre | : Medical |
ISBN | : 1782622373 |
Download New Horizons in Predictive Drug Metabolism and Pharmacokinetics Book in PDF, ePub and Kindle
Drug metabolism, pharmacokinetics and toxicokinetics as determinants of drug attrition and the safety of xenobiotics are critically important. This book presents a comprehensive treatise on the current issues and challenges facing drug metabolism and pharmacokinetics. Readers will find a thorough exploration of their predictive role in impacting drug discovery and development and in improving the success rate and safety assessment of pharmaceuticals and industrial or occupational chemicals. Chapters not only focus on the current state of art, with distinct examples, but on future needs and approaches likely to improve our prediction of potential human risk. Discussions of critical properties that are determinants of a compound’s metabolic and pharmacokinetic fate follow introductory chapters. The Drug Discovery process increasingly incorporates pharmacokinetics and drug metabolism screening and focus has shifted towards in silico, computational and systems biology approaches. Core chapters reflect this and the recent interest and need to assess the role of transporters, along with drug metabolizing enzymes, as potential determinants of pharmacokinetic behaviour, toxicity and drug-drug interactions. Lastly, chapters cover the issues and factors involved in translating pharmacokinetics from in silico to in vivo and from animal models to man, and postulate future directions and opportunities. Leading experts from academia, industry and regulatory bodies across the globe contribute their knowledge to this book, which scientists involved in many aspects of the drug discovery process, as well as regulators and postgraduate students, will find a useful resource.
Author | : Friedlieb Pfannkuch |
Publisher | : John Wiley & Sons |
Total Pages | : 430 |
Release | : 2015-01-20 |
Genre | : Medical |
ISBN | : 3527336087 |
Download Predictive Toxicology Book in PDF, ePub and Kindle
Ein moderner integrierter Ansatz für die Sicherheitsprüfung in der Arzneimittelentwicklung: Dieses Praktikerbuch behandelt In-silico- und In-vitro-Methoden sowie den Einsatz von Biomarkern, mit denen bei kleinen Arzneistoffmolekülen und Biologika frühzeitig und zuverlässig Toxizitäts-Screenings durchgeführt werden können.
Author | : Jinghai J. Xu |
Publisher | : Cambridge University Press |
Total Pages | : |
Release | : 2010-09-27 |
Genre | : Medical |
ISBN | : 1139493094 |
Download Predictive Toxicology in Drug Safety Book in PDF, ePub and Kindle
According to the Institute of Medicine (IOM) and U.S. Food and Drug Administration (FDA), 'developing new scientific approaches to detecting, understanding, predicting and preventing adverse events' was a critical path to the future of drug safety. This book brings together a collection of state-of-the-art chapters, written by experts in the drug safety field. It provides information on the present knowledge of drug side effects and their mitigation strategy during drug discovery, gives guidance for risk assessment and promotes evidence-based toxicology. Each specific area of toxicology relevant for drug discovery is discussed in detail, including theory, experimental approaches and data interpretation supported by comprehensive up-to-date references. Many chapters provide fascinating case studies, which are of general interest for those who have basic science training and are interested in how chemicals interact with the human body.
Author | : International Business Communications, Inc |
Publisher | : |
Total Pages | : |
Release | : 1999 |
Genre | : |
ISBN | : |
Download Predictive Toxicology in Drug Discovery Book in PDF, ePub and Kindle
Author | : |
Publisher | : |
Total Pages | : 0 |
Release | : 2014-02-21 |
Genre | : Medical |
ISBN | : 9781782620921 |
Download Drug Safety and Efficacy Set Book in PDF, ePub and Kindle
A set of books from the Royal Society of Chemistry covering absorption, distribution, metabolism, degradation, efficacy and toxicity of drugs, for pharmaceutical scientists, regulators and medicinal chemistry students.
Author | : Jerry B. Hook |
Publisher | : CRC Press |
Total Pages | : 588 |
Release | : 1993-06-30 |
Genre | : Medical |
ISBN | : 9780881678857 |
Download Toxicology of the Kidney Book in PDF, ePub and Kindle
This second edition provides a synthesis of recent research on the mechanisms of chemically-induced kidney injury. The text includes a review of current concepts of clinical nephrotoxicity and renal failure, and mechanisms of specific classes of nephrotoxic drugs and environmental chemicals.
Author | : Andrew G. Mtewa |
Publisher | : John Wiley & Sons |
Total Pages | : 444 |
Release | : 2020-12-22 |
Genre | : Science |
ISBN | : 1119650232 |
Download Poisonous Plants and Phytochemicals in Drug Discovery Book in PDF, ePub and Kindle
Focusing on phytochemicals and their potential for drug discovery, this book offers a comprehensive resource on poisonous plants and their applications in chemistry and in pharmacology. Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career
Author | : Mark T. D. Cronin |
Publisher | : Royal Society of Chemistry |
Total Pages | : 689 |
Release | : 2010 |
Genre | : Medical |
ISBN | : 1849730040 |
Download In Silico Toxicology Book in PDF, ePub and Kindle
This book defines the use of computational approaches to predict the environmental toxicity and human health effects of organic chemicals.
Author | : Yvonne Will |
Publisher | : John Wiley & Sons |
Total Pages | : 899 |
Release | : 2016-03-22 |
Genre | : Medical |
ISBN | : 1119053390 |
Download Drug Discovery Toxicology Book in PDF, ePub and Kindle
As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices