Mouse Genetics And Transgenics PDF Download
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| Author | : Ian J. Jackson |
| Publisher | : OUP Oxford |
| Total Pages | : 324 |
| Release | : 1999-12-09 |
| Genre | : Science |
| ISBN | : 0191565830 |
Download Mouse Genetics and Transgenics Book in PDF, ePub and Kindle
A unique book that integrates knowledge from a wide range of expertise, specifically applied to the mouse, and addressed at a wide audience from those new to the field to experts who want an update on the state of the art. Mouse Genetics and Transgenics: APA covers all aspects of using the mouse as a genetic model organism: care & husbandry; archiving stocks as frozen embryos or sperm; making new mutations by chemical mutagenesis; transgenesis; and gene targetting; mapping mutations and polygenic traits by cytogenetic, genetic, and physical means; and disseminating and researching information via the Internet.
| Author | : Shree Ram Singh |
| Publisher | : Humana |
| Total Pages | : 0 |
| Release | : 2016-09-17 |
| Genre | : Medical |
| ISBN | : 9781493945672 |
Download Mouse Genetics Book in PDF, ePub and Kindle
Mouse Genetics: Methods and Protocols provide selected mouse genetic techniques and their application in modeling varieties of human diseases. The chapters are mainly focused on the generation of different transgenic mice to accomplish the manipulation of genes of interest, tracing cell lineages and modeling human diseases. Composed in the highly successful Methods in Molecular Biology series format, each chapter contains a brief introduction, a list of necessary materials, systematic, readily reproducible methods and a notes section, which shares tips on troubleshooting in order to avoid known pitfalls. Comprehensive and authoritative, Mouse Genetics: Methods and Protocols promises to deliver fundamental techniques and protocols to geneticists, molecular biologists, cell and developmental biologists, students and postdoctoral fellows working in the various disciplines of mouse biology and modeling human disease.
| Author | : Marten H. Hofker |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 382 |
| Release | : 2008-02-04 |
| Genre | : Science |
| ISBN | : 1592593402 |
Download Transgenic Mouse Methods and Protocols Book in PDF, ePub and Kindle
Marten Hofker and Jan van Deursen have assembled a multidisciplinary collection of readily reproducible methods for working with mice, and particularlyfor generating mouse models that will enable us to better understand gene function. Described in step-by-step detail by highly experienced investigators, these proven techniques include new methods for conditional, induced knockout, and transgenic mice, as well as for working with mice in such important research areas as immunology, cancer, and atherosclerosis. Such alternative strategies as random mutagenesis and viral gene transduction for studying gene function in the mouse are also presented.
| Author | : Jean Louis Guénet |
| Publisher | : Springer |
| Total Pages | : 417 |
| Release | : 2014-11-29 |
| Genre | : Science |
| ISBN | : 3662442876 |
Download Genetics of the Mouse Book in PDF, ePub and Kindle
This book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of the transcriptome, the parental imprinting and X-chromosome inactivation. The strategies for creating all sorts of mutations, either by genetic engineering or by using mutagens, are also reviewed and discussed in detail. Finally, a last chapter outlines the methodology used for the analysis of complex or quantitative traits. The authors also discuss the importance of accurate phenotyping, which is now performed in the mouse clinics established worldwide and identify the limits of the mouse model, which under certain circumstances can fail to present the phenotype expected from the cognate condition in the human model. For each chapter an up-to-date list of pertinent references is provided. In short, this book offers an essential resource for all scientists who use or plan to use mice in their research.
| Author | : Shree Ram Singh |
| Publisher | : Humana |
| Total Pages | : 217 |
| Release | : 2021-02-20 |
| Genre | : Science |
| ISBN | : 9781071610077 |
Download Mouse Genetics Book in PDF, ePub and Kindle
This fully updated edition provides selected mouse genetic techniques and their application in modeling varieties of human diseases. The chapters are mainly focused on the generation of different transgenic mice to accomplish the manipulation of genes of interest, tracing cell lineages, and modeling human diseases. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Mouse Genetics: Methods and Protocols, Second Edition delivers fundamental techniques and protocols to geneticists, molecular biologists, cell and developmental biologists, students, and postdoctoral fellows working in the various disciplines of genetics, developmental biology, mouse genetics, and modeling human diseases.
| Author | : Professor of Molecular Biology Lee M Silver, Professor Dr |
| Publisher | : Oxford University Press on Demand |
| Total Pages | : 362 |
| Release | : 1995 |
| Genre | : Medical |
| ISBN | : 9780195075540 |
Download Mouse Genetics Book in PDF, ePub and Kindle
Mouse Genetics offers for the first time in a single comprehensive volume a practical guide to mouse breeding and genetics. Nearly all human genes are present in the mouse genome, making it an ideal organism for genetic analyses of both normal and abnormal aspects of human biology. Written as a convenient reference, this book provides a complete description of the laboratory mouse, the tools used in analysis, and procedures for carrying out genetic studies, along with background material and statistical information for use in ongoing data analysis. It thus serves two purposes, first to provide students with an introduction to the mouse as a model system for genetic analysis, and to give practicing scientists a detailed guide for performing breeding studies and interpreting experimental results. All topics are developed completely, with full explanations of critical concepts in genetics and molecular biology. As investigators around the world are rediscovering both the heuristic and practical value of the mouse genome, the demand for a succinct introduction to the subject has never been greater. Mouse Genetics is intended to meet the needs of this wide audience.
| Author | : Robert P. Erickson |
| Publisher | : Academic Press |
| Total Pages | : 346 |
| Release | : 2021-08-26 |
| Genre | : Medical |
| ISBN | : 0128240172 |
Download Twentieth Century Mouse Genetics Book in PDF, ePub and Kindle
Twentieth Century Mouse Genetics: A Historical and Scientific Review provides a comprehensive examination of key advances in mouse genetics throughout the 20th century. Here Dr. Robert P. Erickson, a leader in the field, identifies the contributions of historic mouse genetics studies, and how those approaches and early discoveries are still shaping human genetics research and medical genetics today. In addition to historical overviews, the author provides researcher biographies and updates connecting historic research to ongoing advances. Past studies discussed use the T/t complex as an example and include the origins of mouse genetics, the synthesis of genetics and evolution, cytogenetics and gene mapping, population genetics and mutation research, immunogenetics, reproductive genetics, molecular cloning, X-inactivation and epigenetics, sex determination, and pharmacogenetics. Here researchers, students, and clinicians will find fresh inspiration to engage in human genetics research employing mouse models and to translate those findings to clinical practice. Offers a comprehensive examination of key advances in mouse genetics throughout the 20th century Includes updates connecting historic research to ongoing advances Authored by a thought-leader in the field
| Author | : Melissa A. Larson |
| Publisher | : Humana |
| Total Pages | : 236 |
| Release | : 2020-09-12 |
| Genre | : Medical |
| ISBN | : 9781493998395 |
Download Transgenic Mouse Book in PDF, ePub and Kindle
This volume provides readers with a historical foundation in standard techniques and a comprehensive update on the latest methods used in making gene-modified mice. The chapters in this book cover topics such as pronuclear microinjection in one-cell embryos; embryo transfer surgery; nuclear transfer and cloning; blastocyst microinjection; and cryobanking and recovery of genetically modified mice. Importantly, there are chapters devoted to the latest application of CRISPR technology, as well as the establishment of induced pluripotent stem cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Transgenic Mouse: Methods and Protocols is a valuable resource for both novice and expert researchers who are interested in learning more about this evolving field.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 114 |
| Release | : 1999-08-26 |
| Genre | : Science |
| ISBN | : 0309065917 |
Download Microbial and Phenotypic Definition of Rats and Mice Book in PDF, ePub and Kindle
US-Japan meetings on laboratory animal science have been held virtually every year since 1980 under the US-Japan Cooperative Program on Science and Technology. Over the years these meetings have resulted in a number of important documents including the Manual of Microbiologic of Monitoring of Laboratory Animals published in 1994 and the article Establishment and Preservation of Reference Inbred Strains of Rats for General Purposes published in 1991. In addition to these publications, these meetings have been instrumental in increasing awareness of the need for microbiologic monitoring of laboratory rodents and the need for genetic definition and monitoring of mice and rats.
| Author | : Edward D. Levin |
| Publisher | : CRC Press |
| Total Pages | : 395 |
| Release | : 2006-06-22 |
| Genre | : Medical |
| ISBN | : 1420004336 |
Download Animal Models of Cognitive Impairment Book in PDF, ePub and Kindle
The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairmen
