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Monoclonal Antibodies in Transplantation

Monoclonal Antibodies in Transplantation
Author: Lucienne Chatenoud
Publisher: Springer Science & Business Media
Total Pages: 198
Release: 2013-11-22
Genre: Medical
ISBN: 3662221950

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Experimental and clinical evidence presented in this book illustrates that antibodies expressing different specificities can be very effective in preventing or reversing established transplant rejection. Moreover, the data leads us to hope that the use of these new therapeutic agents may allow the induction of specific tolerance to transplant alloantigens which is the only means to avoid the major risks of sustained immunosuppression, namely an increased susceptibility to infection and tumor development. In this volume the editors combine contributions dealing with very practical aspects of the clinical use of monoclonal antibodies with a more general discussion on the developments one may foresee in the near future.


Critical Analysis of Monoclonal Antibody Therapy in Transplantation

Critical Analysis of Monoclonal Antibody Therapy in Transplantation
Author: William J. Burlingham
Publisher: CRC Press
Total Pages: 154
Release: 1991-12-18
Genre: Medical
ISBN: 9780849368219

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Critical Analysis of Monoclonal Antibody Therapy in Transplantation provides a critical analysis of monoclonal antibody therapies in transplantation. The book presents diverse approaches to monoclonal antibody therapy in transplantation and addresses some of the serious obstacles that remain both in understanding these mechanisms and in successfully applying them in clinical situations. The background and rationale for OKT3 therapy are examined and an extensive clinical experience with OKT3 induction therapy in cardiac transplantation is reviewed. The book also examines the background and rationale for the use of anti-TcR (??), anti-IL-2R, and anti-LFA-1 monoclonal antibodies in clinical transplantations. Other topics include the use of monclonal antibodies to CD4 and CD8 for the induction of adult transplantation tolerance in rodents and the possibilities for applying anti-idiotypical strategies that have proven useful in autoimmunity models to transplant recipients. Researchers and basic scientists involved in this field will find the book a fascinating and useful resource for their investigations.


Monoclonal Antibodies in Transplantation

Monoclonal Antibodies in Transplantation
Author: Lucienne Chatenoud
Publisher: Springer
Total Pages: 186
Release: 1995-01-01
Genre: Immunosuppression
ISBN: 9783540601043

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Presents experimental and clinical evidence which illustrates that monoclonal antibodies expressing different specificities can be very effective in preventing or reversing established transplant rejection, further suggesting that the use of these new therapeutic agents may allow the induction of specific tolerance to transplant alloantigens. Annotation copyright by Book News, Inc., Portland, OR


Drug-Induced Liver Injury

Drug-Induced Liver Injury
Author:
Publisher: Academic Press
Total Pages: 288
Release: 2019-07-13
Genre: Medical
ISBN: 0128173173

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Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series


Monoclonal Antibodies

Monoclonal Antibodies
Author: Satya N. Chatterjee
Publisher:
Total Pages: 198
Release: 1985
Genre: Antibodies, Monoclonal
ISBN: 9780884165118

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Cadaveric Renal Transplantation

Cadaveric Renal Transplantation
Author: Yōji Iwasaki
Publisher: Igaku-Shoin Medical Publishers
Total Pages: 316
Release: 1974
Genre: Medical
ISBN:

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Monoclonal Antibodies

Monoclonal Antibodies
Author: Phil S. Shepherd
Publisher: OUP Oxford
Total Pages: 514
Release: 2000-05-04
Genre: Medical
ISBN: 0191565881

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Monoclonal Antibodies: A Practical Approach covers the preparation, testing, derivation, and applications of monoclonal antibodies. New immunological techniques incorporating tried and tested methodologies are described, making the book of interest to established and inexperienced immunologists. Both the standard somatic hybridization technique and recombinant techniques, including the use of phage libraries, for the preparation of rodent and human monoclonal antibodies are described. Protocols for both the small and large scale production are detailed, as well as purification and labelling (with both radioisotopes and non-radioisotopes) methods. The applications of monoclonal antibodies in immunoblotting, enzyme linked immunoassays, immunofluorescence, and FACS analysis are all covered in detail. Finally protocols are given for the use of monoclonal antibodies in rheumatoid arthritis, tissue typing, detecting DNA modified during chemotherapy, and in the clinical analysis of transplantation samples for malignancy. This book will therefore be an invaluable laboratory companion to anyone using monoclonal antibodies in their research.