Monoclonal Antibodies And Their Functional Fragments In Research Diagnosis And Therapy 20 PDF Download
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Author | : Menotti Ruvo |
Publisher | : Mdpi AG |
Total Pages | : 112 |
Release | : 2022-02-11 |
Genre | : Science |
ISBN | : 9783036531656 |
Download Monoclonal Antibodies and Their Functional Fragments in Research, Diagnosis and Therapy 2.0 Book in PDF, ePub and Kindle
Monoclonal antibodies (mAbs) are among the most specialised molecules for the recognition and capture of specific analytes. Hundreds of thousands of mAbs have been generated for a large number of different antigens with increasing affinity and specificity and are available for the most diverse purposes. Many of them have been validated as irreplaceable agents for diagnosis and therapy or as unique reagents for research. Others have been developed using emerging technologies that avoid the need for animal immunisation. This short book strives to gather the perspective view of the various contributing authors and to survey the new strategic assets adopted to generate novel monoclonal antibodies or surrogates, such as Fab, Fab2, ScFv and nanobodies, which have an increasing impact in biomedicine as therapeutic or diagnostic assets in various diseases.
Author | : Menotti Ruvo |
Publisher | : |
Total Pages | : 278 |
Release | : 2022-02-11 |
Genre | : |
ISBN | : 9783036531670 |
Download Monoclonal Antibodies and Their Functional Fragments in Research, Diagnosis and Therapy Book in PDF, ePub and Kindle
Author | : Martin Rosenberg |
Publisher | : Springer Science & Business Media |
Total Pages | : 414 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3642784321 |
Download The Pharmacology of Monoclonal Antibodies Book in PDF, ePub and Kindle
A sample of the most exciting developments in the cloning, manipulation, expression and application of genetically-engineered monoclonal antibodies. This rapidly-evolving field has witnessed the PCR combinatorial cloning of vast immunological diversity, in vitro mutagenesis of MAbs, MAbs created by transgenic animals, novel expression systems in plants, animals and lower systems, as well as a rich variety of genetically modified MAbs as potential therapeutic agents. Leading scientists from academia and industry present their own findings as well as short reviews of these research areas.
Author | : Zhiqiang An |
Publisher | : John Wiley & Sons |
Total Pages | : 932 |
Release | : 2011-09-20 |
Genre | : Science |
ISBN | : 1118210263 |
Download Therapeutic Monoclonal Antibodies Book in PDF, ePub and Kindle
70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety. Most chapters contain experimental data to illustrate the principles described in them. Authors provide detailed methodologies that readers can take away with them and use in their own laboratories.
Author | : Harleen Kaur |
Publisher | : Elsevier |
Total Pages | : 260 |
Release | : 2021-08-03 |
Genre | : Medical |
ISBN | : 0128223197 |
Download Monoclonal Antibodies Book in PDF, ePub and Kindle
Monoclonal antibodies (mAbs) are naturally occurring complex biomolecules. New engineering methods have turned mAbs into a leading therapeutic modality for addressing immunotherapeutic challenges and led to the rise of mAbs as the dominant class of protein therapeutics. mAbs have already demonstrated a great potential in developing safe and reliable treatments for complex diseases and creating more affordable healthcare alternatives. Developing mAbs into well-characterized antibody therapeutics that meet regulatory expectations, however, is extremely challenging. Obstacles to overcome include the determination and development of physiochemical characteristics such as aggregation, fragmentation, charge variants, identity, carbohydrate structure, and higher-order structure (HOS). This book dives deep into mAbs structure and the array of physiochemical testing and characterization methods that need to be developed and validated to establish a mAb as a therapeutic molecule. The main focus of this book is on physiochemical aspects, including the importance of establishing quality attributes such as glycosylation, primary sequence, purity, and HOS and elucidating the structure of new antibody formats by mass spectrometry. Each of the aforementioned quality attributes has been discussed in detail; this will help scientists in researching and developing biopharmaceuticals and biosimilars to find practical solutions to physicochemical testing and characterization. Describes the spectrum of analytical tests and characterization methods necessary for developing and releasing mAb batches Details antibody heterogeneity in terms of size, charge, and carbohydrate content Gives special focus to the structural analysis of mAbs, including mass spectrometry analysis Presents the basic structure of mAbs with clarity and rigor Addresses regulatory guidelines - including ICH Q6B - in relation to quality attributes Lays out characterization and development case studies including biosimilars and new antibody formats
Author | : Suresh C. Srivastava |
Publisher | : Springer Science & Business Media |
Total Pages | : 851 |
Release | : 2013-03-14 |
Genre | : Medical |
ISBN | : 1468455389 |
Download Radiolabeled Monoclonal Antibodies for Imaging and Therapy Book in PDF, ePub and Kindle
The advent of hybridoma technology leading to the successful produc tion of monoclonal antibodies against a variety of tumor-associated antigens has, during the last decade, provided a very powerful tool for research and clinical investigations. These highly specific reagents have essentially replaced the polysera of the earlier days. The successful demonstration of the many wide ranging capabilities of the monoclonal antibody technique has already begun to exert an enormous impact on diverse areas of research in basic science and medicine. In particular, the potential of monoclonal antibodies to serve as carriers for selective targeting of radionuclides to tumors for diagnosis or therapy, has stimulated an intense surge of research interest and even revived hopes of realizing Ehrlich's concept of the "magic bullet". Indeed, the technology appears to be on the threshold of a revolution in diagnosing and treating malignant disease. Much work remains to be done, however, and even though the progress has been impressive, results to date have shown only moderate success. There is no question that the limited success we have achieved thus far is merely a prelude to the many more exciting developments yet to come.
Author | : Maher Albitar |
Publisher | : Springer Science & Business Media |
Total Pages | : 472 |
Release | : 2008-02-02 |
Genre | : Medical |
ISBN | : 1597453234 |
Download Monoclonal Antibodies Book in PDF, ePub and Kindle
This book examines a collection of state-of-the-art methods that employ monoclonal antibodies in a clinical setting. The chapters offer in-depth description for generating mouse and recombinant humanized antibodies, and a comprehensive review of how antibodies are being used in bead-based methods for measuring proteins. This field will continue to expand and provide new and innovative techniques in the laboratory and as a basis that complements targeted therapy.
Author | : Nima Rezaei |
Publisher | : BoD – Books on Demand |
Total Pages | : 172 |
Release | : 2021-06-23 |
Genre | : Medical |
ISBN | : 1839683694 |
Download Monoclonal Antibodies Book in PDF, ePub and Kindle
Immune-based therapies are being studied extensively in a variety of immunological conditions due to their high precision and sensitivity. Monoclonal antibody (mAb) technology is a major advancement in the treatment of several infectious diseases, malignancies, and immunological disorders. This book provides comprehensive information about technologies, characterization, and application of mAbs in the clinic and laboratory.
Author | : Yuti Chernajovsky |
Publisher | : Springer |
Total Pages | : 380 |
Release | : 2007-11-22 |
Genre | : Medical |
ISBN | : 9783540732587 |
Download Therapeutic Antibodies Book in PDF, ePub and Kindle
This essential work, edited by two researchers at London’s famous Queen Mary’s medical school targets one of the most important areas in medical development today. These days, antibody therapeutics are the treatment of choice for several autoimmune and oncological conditions. They are, indeed, becoming the molecules of choice for further combination therapies and cell engineering. In this timely work, a slew of expert in the field of drug development summarize all the current developments and clinical successes.
Author | : J. R. Birch |
Publisher | : Wiley-Liss |
Total Pages | : 368 |
Release | : 1995-03-02 |
Genre | : Medical |
ISBN | : |
Download Monoclonal Antibodies Book in PDF, ePub and Kindle
General introduction. Applications. Genetic manipulation and expression of antibodies. Modification of antibodies by chemical methods. The production of monoclonal antibodies. Blosafety considerations. Antibody patents.