Molecular Mechanisms of Nociception
Author | : Fabien Marchand |
Publisher | : Frontiers Media SA |
Total Pages | : 207 |
Release | : 2022-10-17 |
Genre | : Science |
ISBN | : 2832502555 |
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Author | : Fabien Marchand |
Publisher | : Frontiers Media SA |
Total Pages | : 207 |
Release | : 2022-10-17 |
Genre | : Science |
ISBN | : 2832502555 |
Author | : Donald Iain MacDonald |
Publisher | : |
Total Pages | : |
Release | : 2020 |
Genre | : |
ISBN | : |
Author | : Joyce A. De Leo |
Publisher | : |
Total Pages | : 464 |
Release | : 2007 |
Genre | : Medical |
ISBN | : |
"Review of immune and glial factors within the peripheral and central nervous systems that relate to chronic pain states. Discussion of novel immune and glial targets for clinical pain control that may yield new analgesic drugs"--Provided by publisher.
Author | : Melanie Rose Chin |
Publisher | : |
Total Pages | : 0 |
Release | : 2021 |
Genre | : Drosophila |
ISBN | : |
In order to survive, an organism must be able to sense its surroundings. One particularly important sense is the processes of nociception, the ability to detect noxious stimuli. In Drosophila, when a noxious stimulus is sensed, larvae will perform a distinct rolling behavior. It is valuable to investigate the molecular mechanisms that give rise to the Drosophila larva's ability to sense noxious stimuli and to produce nociceptive rolling behavior as this will allow for a greater understanding of the nociceptive neural circuit and further insight into sensory perception. With the strong homology between Drosophila genes and human genes, these studies could find new targets for pain management. The initial focus of this dissertation was the gene defective proboscis extension response 11 (dpr11). dpr11 is a member of the immunoglobulin superfamily of proteins and it is part of a recently discovered protein network, the Dprome. It was my hypothesis that Dpr11 acts at synapses of nociceptor neurons to direct the formation of connections to downstream secondary neurons. While dpr11 was not found necessary for nociceptive behavior in Drosophila, gene expression studies supported the hypothesis that dpr11 and its binding partners DIP-gamma and DIP-beta are expressed in the nociception circuit. Importantly, dpr11-RNAi tests confirmed an off-target effect on another gene paralytic. Paralytic codes for the only voltage-gated sodium channel in Drosophila, and it is highly processed with many alternative transcripts. This study presents evidence that there are novel isoforms of para that may have a role in thermal nociception. This is a unique finding that relates to pain mechanisms in vertebrates as para is homologous to human voltage-gated sodium channels that are implicated in pain processing. This dissertation will also touch on TRP channels involved in sensory processing, including a mechanotransduction channel nompC and dTRPA1, the Drosophila homolog of human TRPA1. Data present a model for a novel role for nompC in the glia of the Drosophila larval brain, and information on the regulation of dTRPA1 in Drosophila nociceptive neurons. In summary, this dissertation broadly investigates the genetics behind neural circuit formation and sensory transduction processes, lending insight into how genes contribute to behavior and adding important information to the field of pain processing.
Author | : Wolfgang B. Liedtke, MD, PH.D. |
Publisher | : CRC Press |
Total Pages | : 502 |
Release | : 2006-09-29 |
Genre | : Medical |
ISBN | : 1420005847 |
Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st
Author | : Raymond S. Sinatra |
Publisher | : Cambridge University Press |
Total Pages | : 729 |
Release | : 2009-04-27 |
Genre | : Medical |
ISBN | : 0521874912 |
This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.
Author | : Howard L. Fields |
Publisher | : Elsevier Publishing Company |
Total Pages | : 454 |
Release | : 1988-01-01 |
Genre | : Medical |
ISBN | : 9780444809841 |
This volume represents edited material that was presented at a conference on brainstem modulation of spinal nociception held in Beaune, France during July, 1987. Pain Modulation, Volume 77 in the series Progress in Brain Research reviews, analyses and suggests new research strategies on several relevant topics including: the endogenous opioid peptides; sites of action of opiates; the role of biogenic animes and non-opioid peptides in analgesia; dorsal horn circuitry; behavioural factors in the activation of pain modulating networks and clinical studies of nociceptive modulation.
Author | : John N. Wood |
Publisher | : Oxford University Press, USA |
Total Pages | : 939 |
Release | : 2020 |
Genre | : Medical |
ISBN | : 0190860502 |
This handbook is currently in development, with individual articles publishing online in advance of print publication. At this time, we cannot add information about unpublished articles in this handbook, however the table of contents will continue to grow as additional articles pass through the review process and are added to the site. Please note that the online publication date for this handbook is the date that the first article in the title was published online.
Author | : Wuping Sun |
Publisher | : Frontiers Media SA |
Total Pages | : 141 |
Release | : 2022-02-22 |
Genre | : Science |
ISBN | : 2889744663 |
Author | : Stephen P. Hunt |
Publisher | : Molecular and Cellular Neurobi |
Total Pages | : 422 |
Release | : 2005 |
Genre | : Medical |
ISBN | : 9780198515616 |
The last decade has seen major advances in the neurobiology of pain, primarily resulting from a deeper understanding of the way in which pain signals are coded and processed in the nervous system. This volume in the Molecular and Cellular Neurobiology is the first book for many years to present an integrated overview of the current state of research into the neurobiology of chronic and acute pain. While recent molecular aspects of nociception are covered in some detail, the book also emphasises the importance of viewing the pain experience as the co-ordinated response of many different areas of the nervous system. The molecular advances are set in the context of the neurobiological system of pain processing. The appropriate behavioural response to injury can therefore be thought of as the result of the integration of information processed within areas of the brain concerned with cognition, affect, sensory discrimination and movement. Chapters cover recent advances in nociceptor transduction mechanisms, nociceptor plasticity and the biochemical anatomy of pain pathways. Other contributions are concerned with the development of pain systems and with the central processing of nociceptive information studied with brain imaging techniques. Several chapters additionally cover the mechanisms of clinically important pain states such as neuropathic pain, cancer related pain and migraine. A new volume in the Molecular and Cellular Neurobiology series, this volume presents a state-of-the-art account of the neurobiological basis of pain, edited and written by the leading scientists in this field.