Modulation Of T Cell Function And Survival By The Tumor Microenvironment PDF Download
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Author | : Shahrzad Jalali |
Publisher | : Frontiers Media SA |
Total Pages | : 115 |
Release | : 2023-09-26 |
Genre | : Science |
ISBN | : 283253435X |
Download Modulation of T-cell function and survival by the tumor microenvironment Book in PDF, ePub and Kindle
Author | : Suzanne L. Walker |
Publisher | : |
Total Pages | : |
Release | : 2018-10 |
Genre | : |
ISBN | : 9781635930184 |
Download Guide to Immunotherapy Book in PDF, ePub and Kindle
Author | : Jonathan Soboloff |
Publisher | : CRC Press |
Total Pages | : 258 |
Release | : 2017-03-27 |
Genre | : Medical |
ISBN | : 149870509X |
Download Signaling Mechanisms Regulating T Cell Diversity and Function Book in PDF, ePub and Kindle
T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Author | : Z. Kmiec |
Publisher | : Springer Science & Business Media |
Total Pages | : 154 |
Release | : 2013-06-29 |
Genre | : Science |
ISBN | : 3642565530 |
Download Cooperation of Liver Cells in Health and Disease Book in PDF, ePub and Kindle
It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.
Author | : M.E. Gershwin |
Publisher | : Elsevier |
Total Pages | : 467 |
Release | : 2000-03-27 |
Genre | : Medical |
ISBN | : 0080528457 |
Download Cancer and Autoimmunity Book in PDF, ePub and Kindle
Of the two disciplines in parallel development for two decades, tumor immunology and transplantation immunology, the latter has thrived and has led to some of the most critical discoveries in immunobiology. The former continues to thwart both scientists and clinicians alike.The goal of immunologists in modern day research is to develop a simple and effective means to manipulate cancer in vivo, possibly encompassing several venues: identifying a phenotypic marker and the use of either active or passive immunization; include the use of passive reagents carrying "warheads" to selectively destroy cancer cells; or altering the basic process of cell survival.This excellent multidiscipline-authored volume presents a theme which has not been well described before. The papers include both basic and clinical science and range from sophisticated molecular biology to little more than phenomenology (e.g. the increased association of cancer in some autoimmune diseases and increased presentation of autoimmune phenomena in malignant condition). This, however, is state-of-the-art.This collection of themes will be of use not only to bench scientists, but also to clinicians who treat patients. The book represents progress at the cutting edge of this discipline, and points the way to further developments in the "black box" of immunology.
Author | : Shuren Zhang |
Publisher | : Springer |
Total Pages | : 293 |
Release | : 2016-05-30 |
Genre | : Medical |
ISBN | : 9401775559 |
Download Progress in Cancer Immunotherapy Book in PDF, ePub and Kindle
This book provides readers an extensive overview of recent progress in basic and clinical research on cancer immunotherapy. Thanks to rapid advances in molecular biology and immunology, it has become increasingly evident that cancer growth is influenced by host immune responses. With the success of a number of clinical trials, immunotherapy has become a promising treatment modality of cancer. This book covers five major topics, including monoclonal antibodies, biological response modifiers, cancer vaccines, adoptive cellular therapy and oncolytic viruses. It also examines the combination of different immune strategies as well as the combination of immunotherapy with other treatments to increase anti-tumor effects. Through the comprehensive discussion of the topic, the book sheds valuable new light on the treatment of tumors.
Author | : Fumito Ito |
Publisher | : Elsevier Health Sciences |
Total Pages | : 400 |
Release | : 2018-09-03 |
Genre | : Medical |
ISBN | : 0323549500 |
Download Immune Checkpoint Inhibitors in Cancer Book in PDF, ePub and Kindle
Get a quick, expert overview of the latest clinical information and guidelines for cancer checkpoint inhibitors and their implications for specific types of cancers. This practical title by Drs. Fumito Ito and Marc Ernstoff synthesizes the most up-to-date research and clinical guidance available on immune checkpoint inhibitors and presents this information in a compact, easy-to-digest resource. It’s an ideal concise reference for trainee and practicing medical oncologists, as well as those in research. Discusses the current understanding of how to best harness the immune system against different types of cancer at various stages. Helps you translate current research and literature into practical information for daily practice. Presents information logically organized by disease site. Covers tumor immunology and biology; toxicities associated with immune checkpoint inhibitors; and future outlooks. Consolidates today’s available information on this timely topic into one convenient resource.
Author | : Sybille Mazurek |
Publisher | : Springer |
Total Pages | : 373 |
Release | : 2015-01-19 |
Genre | : Medical |
ISBN | : 3709118247 |
Download Tumor Cell Metabolism Book in PDF, ePub and Kindle
The four sections of this book cover cell and molecular biology of tumor metabolism, metabolites, tumor microenvironment, diagnostics and epigenetics. Written by international experts, it provides a thorough insight into and understanding of tumor cell metabolism and its role in tumor biology. The book is intended for scientists in cancer cell and molecular biology, scientists in drug and diagnostic development, as well as for clinicians and oncologists.
Author | : Bin Li |
Publisher | : Springer |
Total Pages | : 223 |
Release | : 2017-09-22 |
Genre | : Medical |
ISBN | : 9789402411683 |
Download Immune Metabolism in Health and Tumor Book in PDF, ePub and Kindle
This book offers a broad overview of the concepts and research findings in immunometabolism. The immune system is made up of numerous different cell types, pathways, and components that must be able to respond rapidly to a pathogen or cancer, but must also remain quiescent in the absence of challenges. Immune cells rely on metabolic pathways to adapt to changing environments and stimuli. Additionally, these cells can be modified in function or fate by fluctuations in available nutrients. The chapters in this book describe ways in which immune cells utilize and are regulated by metabolic pathways. Topics include how immune-cell metabolism shapes immune homeostasis, and how dysregulation of these pathways can lead to immune disorders. In different contexts, such as a tumor microenvironment, immune-cell function and identity may be modified not only by cytokines and checkpoint molecules, but also by nutrient availability and other metabolic stimuli. Transcriptional reprogramming confers many of the changes in immune cell metabolism that are seen when a T-cell, for example, undergoes activation or functional adaptation to different environments. Lastly, immune cells can destructively or protectively participate in human metabolic homeostasis or disorders. This book summarizes immune-metabolism from a variety of different perspectives, including the ways in which metabolic cues, pathways, and requirements of immune cells change in conditions of homeostasis and activation. The exploration of the significance of metabolic checkpoints and other cues, particularly in the context of cancer and immune disorders, may form the foundation for the development of therapeutics.
Author | : Jamie A. Goode |
Publisher | : John Wiley & Sons |
Total Pages | : 322 |
Release | : 2001-11-28 |
Genre | : Science |
ISBN | : 9780471499596 |
Download The Tumour Microenvironment Book in PDF, ePub and Kindle
Ergebnisse von in vitro-Studien lassen vermuten, dass sich der pH-Wert in einem Tumor auf die Wirksamkeit von Chemo- oder Strahlentherapien auswirken kann. Wie aber sieht die Beziehung zwischen der Tumorentwicklung und dem pH-Wert aus? Können ein niedriger pH-Wert oder ein Sauerstoffmangel die Carcinogenese hemmen? Wo bieten sich therapeutische Ansätze? Anwort auf diese und andere Fragen finden Sie in diesem Band. In interdisziplinärer Weise wurden Beiträge aus der Grundlagenforschung und der klinischen Praxis zusammengetragen.