Mitochondrial Dynamics In Cardiovascular Medicine PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Mitochondrial Dynamics In Cardiovascular Medicine PDF full book. Access full book title Mitochondrial Dynamics In Cardiovascular Medicine.
| Author | : Gaetano Santulli |
| Publisher | : Springer |
| Total Pages | : 644 |
| Release | : 2017-05-25 |
| Genre | : Science |
| ISBN | : 3319553305 |
Download Mitochondrial Dynamics in Cardiovascular Medicine Book in PDF, ePub and Kindle
This text covers the basic principles of mitochondrial dynamics in cardiovascular medicine, with particular emphasis on their functional roles in physiology and disease. The book will include articles pertaining to mitochondrial fitness on a global basis, providing therefore an update on the progress made in several aspects in the field. Thus, it will assist scientists and clinicians alike in furthering basic and translational research. Organized in sections focusing on: basic science, mitochondrial dysfunction in cardiac disorders, in vascular disorders, in metabolic disorders, in kidney disease, therapeutic challenges and options, this essential volume fills imperative gaps in understanding and potentially treating several cardiovascular disorders.
| Author | : José Marín-García |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 495 |
| Release | : 2012-11-19 |
| Genre | : Medical |
| ISBN | : 146144599X |
Download Mitochondria and Their Role in Cardiovascular Disease Book in PDF, ePub and Kindle
Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significant advances in the field of mitochondrial cardiovascular medicine. The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics. Subsequent chapters deal with mitochondrial oxidative stress and the role that the organelle plays in cell signaling and cell death. Discussions will be undertaken on the biochemistry of mitochondrial cell signaling, including the nature of the proteins engaged in these processes, many of them only recently discovered. Later chapters examine the role of mitochondria and mitochondrial abnormalities in cardiovascular diseases, including their diagnosis, therapeutic options currently available, animal models of mitochondrial disease, and new frontiers in mitochondria cardiovascular medicine, including areas of research that are relatively new or developing, such as proteomics, next generation sequencing, and systems biology.
| Author | : José Marín-García |
| Publisher | : Springer |
| Total Pages | : 500 |
| Release | : 2012-11-17 |
| Genre | : Medical |
| ISBN | : 9781461446002 |
Download Mitochondria and Their Role in Cardiovascular Disease Book in PDF, ePub and Kindle
Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significant advances in the field of mitochondrial cardiovascular medicine. The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics. Subsequent chapters deal with mitochondrial oxidative stress and the role that the organelle plays in cell signaling and cell death. Discussions will be undertaken on the biochemistry of mitochondrial cell signaling, including the nature of the proteins engaged in these processes, many of them only recently discovered. Later chapters examine the role of mitochondria and mitochondrial abnormalities in cardiovascular diseases, including their diagnosis, therapeutic options currently available, animal models of mitochondrial disease, and new frontiers in mitochondria cardiovascular medicine, including areas of research that are relatively new or developing, such as proteomics, next generation sequencing, and systems biology.
| Author | : Sebastiano Sciarretta |
| Publisher | : Frontiers Media SA |
| Total Pages | : 111 |
| Release | : 2021-03-04 |
| Genre | : Medical |
| ISBN | : 2889665569 |
Download Mitochondrial Dysfunction and Cardiovascular Diseases Book in PDF, ePub and Kindle
| Author | : Giampaolo Morciano |
| Publisher | : Frontiers Media SA |
| Total Pages | : 182 |
| Release | : 2021-06-21 |
| Genre | : Science |
| ISBN | : 2889669424 |
Download Mitochondrial Remodeling and Dynamic Inter-Organellar Contacts in Cardiovascular Physiopathology Book in PDF, ePub and Kindle
| Author | : José Marín-García |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 416 |
| Release | : 2005-12-17 |
| Genre | : Medical |
| ISBN | : 0387255753 |
Download Mitochondria and the Heart Book in PDF, ePub and Kindle
Mitochondria have been pivotal in the development of some of the most important ideas in modern biology. Since the discovery that the organelle has its own DNA and specific mutations were found in association with neuromuscular and cardiovascular diseases and with aging, an extraordi-nary number of publications have followed, and the term mitochondrial medicine was coined. Furthermore, our understanding of the multiple roles that mitochondria play in cardiac cell homeostasis opened the door for intensive experimentation to understand the pathogenesis and to find new treatments for cardiovascular diseases. Besides its role in adenosine triphosphate generation, mitochondria regu-late a complex network of cellular interactions, involving (1) generation and detoxification of reactive oxygen species, including superoxide anion, hy-drogen peroxide, and hydroxyl radical; (2) maintenance of the antioxidant glutathione in a reduced state and adequate level of mitochondrial matrix superoxide dismutase; (3) cytoplasmic calcium homeostasis, particularly under conditions of cellular calcium loading; (4) transport of metabolites between cytoplasm and matrix; (5) both programmed (apoptosis) and necrotic cell death; and (6) cell growth and development. It is therefore not surprising that this organelle has come to be the center stage in many current investigations of cardiovascular diseases, aging, and agi- related disease. Concomitant with these advances, an impressive effort is under- way for the development of new tools and methodologies to study mitochondrial structure and function, including powerful ways to visualize, monitor, and alter the organelle function to assess the genetic consequences of these perturbations.
| Author | : |
| Publisher | : |
| Total Pages | : 102 |
| Release | : 2014 |
| Genre | : |
| ISBN | : 9781321125467 |
Download The Effect of Pim Kinases Upon Mitochondrial Dynamics and Metabolism Book in PDF, ePub and Kindle
Myocardial aging is an independent risk factor for cardiovascular disease. Cardiac aging promotes adverse myocardial remodeling and the accumulation of poorly functioning senescent cells, leading to a decline in cardiac performance. Pathological remodeling is associated, in part, with changes occurring at the mitochondrial level exacerbating heart disease. Mitochondrial alteration during heart failure includes cellular changes in fuel utilization and alterations in mitochondrial dynamics, implicating mitochondrial biology as an important facet of cardiac aging biology. Pim kinases are protective in a cardiac context, in part by maintaining mitochondrial integrity. However, Pim protein expression diminishes during cardiac aging. Therefore, cardiac mitochondrial dynamics and metabolism were investigated in relationship to Pim kinases. The relationship between Pim1 and Dynamin Related Protein 1 (Drp1) was assessed as a novel mechanism to prevent Drp1 mediated fission. Drp1 mediates fission by mitochondrial localization during pathological challenge, sensitizing cardiomyocytes to apoptosis. Overexpressing Pim1 decreased total Drp1 levels, increased phosphorylation of Drp1 at serine 637, and inhibited Drp1 localization to mitochondria while preserving reticular morphology after simulated ischemia. Overexpression of Pim1 dominant negative (PDN) increased total mitochondrial Drp1, reduced phospho Drp1, and increased mitochondrial fragmentation. PDN hearts exhibit upregulation of BH3 only protein p53 upregulated modulator of apoptosis (PUMA) that mediates mitochondrial Drp1 accumulation and increased sensitivity to apoptotic stimuli. Therefore, Pim1 activity prevents Drp1 compartmentalization to the mitochondria and preserves reticular mitochondrial morphology. Cellular pathological hypertrophic remodeling and fetal gene program activation was evident in Pim Triple KnockOut (PTKO) mice phenotypic of cardiac aging. Cardiomyocyte senescence manifested by increased expression of cell cycle inhibitors and decreased telomere lengths. Changes in expression of PPAR[gamma] coactivator-1 (PGC-1) [alpha] and [Beta] led to alterations in mitochondrial ultrastructure and metabolism. An energy-starved phenotype was determined with decreased ATP and increased pAMPK:AMPK ratio, confirming changes in the PPAR signaling circuit. Overexpression of PGC-1[alpha] and c-Myc rescued changes in metabolism and restored energy homeostasis. These studies confirm the significant impact of Pim kinases on mitochondrial biology and support the notion to utilize Pim as a tool to prevent cardiac aging by preserving mitochondrial dynamics and metabolism.
| Author | : Raphael Jason |
| Publisher | : Independently Published |
| Total Pages | : 0 |
| Release | : 2023-12-08 |
| Genre | : Health & Fitness |
| ISBN | : |
Download Mitochondrial Dynamics Book in PDF, ePub and Kindle
"Mitochondrial Dynamics: Bridging the Gap Between Health and Dysfunction" by Raphael Jason is a book that delves into the intricate world of mitochondrial dynamics and its significance in cellular function. The book explores the processes of fusion, fission, mitophagy, and transport, and how they contribute to the adaptive flexibility needed to adjust to changing cellular stresses and metabolic demands. It discusses the molecular mechanisms that regulate mitochondrial dynamics and how they differ in healthy and diseased states.The book highlights the importance of understanding mitochondrial dynamics in the context of various diseases, such as cardiovascular diseases, Alzheimer's disease, muscular dystrophy, type 1 diabetes, multiple sclerosis, cancer, and aging. It also emphasizes the need for developing therapeutic interventions targeting mitochondrial function to manage or prevent these conditions. Some key aspects of the book include: A comprehensive overview of the molecular mechanisms governing mitochondrial fusion and fission. A detailed exploration of the role of mitochondrial dynamics in various cellular functions, such as energy production, apoptosis, reactive oxygen species levels, mitophagy, and ion metabolism. A discussion on the potential of mitochondrial dynamics as a therapeutic strategy for acute kidney injury and other diseases. An examination of the gaps in our understanding of mitochondrial dynamics and the most pressing research questions that need to be addressed in this field. By providing a thorough understanding of mitochondrial dynamics and their role in health and disease, "Mitochondrial Dynamics: Bridging the Gap Between Health and Dysfunction" serves as a valuable resource for researchers, clinicians, and students interested in the future of mitochondrial medicine.
| Author | : Shijun Wang |
| Publisher | : Frontiers Media SA |
| Total Pages | : 245 |
| Release | : 2022-07-27 |
| Genre | : Medical |
| ISBN | : 2889766209 |
Download Mitochondrial Metabolism in Ischemic Heart Disease Book in PDF, ePub and Kindle
| Author | : Lawrence H. Lash |
| Publisher | : Elsevier |
| Total Pages | : 527 |
| Release | : 2013-10-22 |
| Genre | : Science |
| ISBN | : 1483218619 |
Download Mitochondrial Dysfunction Book in PDF, ePub and Kindle
Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.
