Mitochondria In Obesity And Type 2 Diabetes PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Mitochondria In Obesity And Type 2 Diabetes PDF full book. Access full book title Mitochondria In Obesity And Type 2 Diabetes.
Author | : Beatrice Morio |
Publisher | : Academic Press |
Total Pages | : 460 |
Release | : 2019-04-26 |
Genre | : Science |
ISBN | : 0128117524 |
Download Mitochondria in Obesity and Type 2 Diabetes Book in PDF, ePub and Kindle
Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases synthesizes discoveries from laboratories around the world, enhancing our understanding of the involvement of mitochondria in the etiology of diseases, such as obesity and type 2 diabetes. Chapters illustrate and provide an overview of key concepts on topics such as the role of mitochondria in adipose tissue, cancer, cardiovascular comorbidities, skeletal muscle, the liver, kidney, and more. This book is a must-have reference for students and educational teams in biology, physiology and medicine, and researchers. Synthesizes actual knowledge on mitochondrial function Provides an integrated vision of each tissue in the etiology of obesity and type 2 diabetes Identifies the interactive networks that involve alteration in mitochondrial mass and function in disease progression Highlights the role played by mitochondria in the prevention and treatment of obesity and type 2 diabetes
Author | : Lawrence H. Lash |
Publisher | : Elsevier |
Total Pages | : 527 |
Release | : 2013-10-22 |
Genre | : Science |
ISBN | : 1483218619 |
Download Mitochondrial Dysfunction Book in PDF, ePub and Kindle
Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.
Author | : Jessica Erin Sacks |
Publisher | : |
Total Pages | : 204 |
Release | : 2018 |
Genre | : Insulin resistance |
ISBN | : |
Download Targeting Mitochondrial Pathways in Obesity and Type 2 Diabetes Book in PDF, ePub and Kindle
Obesity is one of the largest medical epidemics our society faces today. There are over forty obesity-associated diseases that affect nearly every organ system in the body, including Type 2 Diabetes (T2D) and Non-Alcoholic Fatty Liver Disease (NAFLD). Insulin resistance is one of the hallmark characteristics underlying metabolic diseases, and mitochondrial dysfunction is believed to be a central player in this phenomenon, yet our understanding of the specific molecular mechanisms that serve as cause and consequence of defective mitochondria remain complex and elusive despite significant attention. In the studies presented in this dissertation, liver tissue isolated from a rat model of obesity-induced NAFLD and human subject-derived skeletal muscle cells revealed two distinct mechanisms by which mitochondrial dynamics may play a key role in regulating the progression of insulin resistance and cellular bioenergetics in obesity-related metabolic diseases. First, we found that markers of mitochondrial fusion and biogenesis are upregulated in the liver of obese Sprague-Dawley rats following gastric bypass surgery, and expression of a specific fusion marker, namely mitofusin 1, is associated with reductions in body weight and improved insulin sensitivity. Utilizing human primary skeletal muscle cells isolated from percutaneous needle biopsy, we found that metformin treatment in vitro upregulates glycolytic pathways, suppresses mitochondrial respiration, and activates a specific protein of mitochondrial fission. Together, the work presented here describes mitochondrial mechanisms related to insulin resistance in two obesity models and major metabolic tissues.
Author | : John J. Lemasters |
Publisher | : Springer Science & Business Media |
Total Pages | : 533 |
Release | : 2007-05-08 |
Genre | : Science |
ISBN | : 0306468352 |
Download Mitochondria in Pathogenesis Book in PDF, ePub and Kindle
Mitochondria are organelles in each cell outside the nucleus and are the energy source of all cells. As such, they are crucial to the healthy functioning of cells. Recent research has shown that mitochondrial dysfunction underlies a broad spectrum of disease, from maternally inherited genetic disorders to metabolism defects, aging, stroke, and neurodegenerative diseases such as Parkinson's, Alzheimer's, and Lou Gehrig's disease. This book brings together top researchers whose work in examining the pathophysiologic processes will lead to new strategies for prevention and treatment.
Author | : Fabrizio Barbetti |
Publisher | : |
Total Pages | : 0 |
Release | : 2017 |
Genre | : Chromosome abnormalities |
ISBN | : 9783318060249 |
Download Diabetes Associated with Single Gene Defects and Chromosomal Abnormalities Book in PDF, ePub and Kindle
This volume, written by renowned experts, provides complete coverage of the main genetic conditions associated with diabetes. Divided into five sections, it offers insights into genetic defects involving the pancreatic beta cell, extreme insulin resistance, ciliopathies, obesity and glucose metabolism, chromosomal defects, and other genetic conditions associated with increased susceptibility to diabetes. Other topics include the various subtypes of monogenic diabetes, such as the neonatal form and the Wolfram syndrome, as well as chromosomal defects leading to complex conditions affiliated with diabetes, like Trisomy 21 or Prader-Willi syndrome. There are also chapters dedicated to the poorly explored relationships between metabolism and neurodegenerative disorders like Friedreich's ataxia and muscular dystrophy. This book is a reference for every pediatric and adult endocrinologist and diabetologist, even experienced ones, with an interest in the intricacies and protean aspects of disorders of glucose metabolism secondary to genetic diseases.
Author | : |
Publisher | : |
Total Pages | : |
Release | : 2021 |
Genre | : Gene expression |
ISBN | : 9781071608340 |
Download Mitochondrial Gene Expression Book in PDF, ePub and Kindle
Author | : Peter Pribis |
Publisher | : MDPI |
Total Pages | : 309 |
Release | : 2018-08-09 |
Genre | : Electronic books |
ISBN | : 3038429163 |
Download Nutrition and Diet Factors in Type 2 Diabetes Book in PDF, ePub and Kindle
This book is a printed edition of the Special Issue "Nutrition and Diet Factors in Type 2 Diabetes" that was published in Nutrients
Author | : H. Böhles |
Publisher | : CRC Press |
Total Pages | : 188 |
Release | : 2004 |
Genre | : Cardiomyopathy |
ISBN | : 9783887631048 |
Download Metabolic Cardiomyopathy Book in PDF, ePub and Kindle
During the last years the understanding for the aetiology of cardiomyopathies could be greatly improved. A great deal of information has accumulated in the field of inherited metabolic diseases, which provides a new basis for our understanding of many heart muscle problems and their corresponding clinical disease entities. This book is meant to give the reader a comprehensive overview of the cardiological manifestations of inborn errors of metabolism. Latest information, such as cardiomyopathy in Fabry disease or in patients with CDG-syndrome is included. It should be helpful, not only to cardiologists, paediatricians, internists and general practicioners, but also to all those interested in a better understanding of the metabolic basis of clinical disease entities.
Author | : Alan R. Saltiel |
Publisher | : Springer Science & Business Media |
Total Pages | : 223 |
Release | : 2007-10-05 |
Genre | : Medical |
ISBN | : 0387722041 |
Download Mechanisms of Insulin Action Book in PDF, ePub and Kindle
More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.
Author | : Todd Leff |
Publisher | : John Wiley & Sons |
Total Pages | : 530 |
Release | : 2010-03-19 |
Genre | : Science |
ISBN | : 9783527629534 |
Download Adipose Tissue in Health and Disease Book in PDF, ePub and Kindle
This timely and most comprehensive reference available on the topic covers all the different aspects vital in the fight against the global obesity epidemic. Following a look at adipose tissue development and morphology, the authors go on to examine its metabolic and endocrine functions and its role in disease. The final section deals with comparative and evolutionary aspects of the tissue. The result is an essential resource for cell and molecular biologists, physiologists, biochemists, pharmacologists, and those working in the pharmaceutical industry.