Methods In Mouse Atherosclerosis PDF Download
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| Author | : Vicente Andrés |
| Publisher | : Humana |
| Total Pages | : 0 |
| Release | : 2015-10-09 |
| Genre | : Science |
| ISBN | : 9781493929283 |
Download Methods in Mouse Atherosclerosis Book in PDF, ePub and Kindle
This volume reviews available mouse models of atherosclerosis, basic aspects of disease initiation and progression, and the visualization of atherosclerotic lesions with invasive and non-invasive techniques that are widely used both in basic research and in the clinic. The chapters catalogue a wide range of in vitro and in vivo experimental methods used for atherosclerosis research, including thorough protocols and valuable notes based on the authors’ personal wet lab experience. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Methods in Mouse Atherosclerosis will be a valuable working guide for researchers performing mouse-based atherosclerosis studies.
| Author | : Qingbo Xu |
| Publisher | : Wiley |
| Total Pages | : 402 |
| Release | : 2006-08-04 |
| Genre | : Science |
| ISBN | : 0470028785 |
Download A Handbook of Mouse Models of Cardiovascular Disease Book in PDF, ePub and Kindle
The availability of well-defined genetic strains and the ability to create transgenic and knockout mice makes mouse models extremely valuable biomedical tools. Their suitability as an experimental system for cardiovascular research depends on the individual investigator’s ability to manipulate the mice surgically. Many mouse models require microsurgical techniques, which hitherto could not be performed without practical training. This comprehensive handbook enables scientists to develop these models in their own laboratories. A Handbook of Mouse Models of Cardiovascular Disease is the first book to address pathology in mouse models of heart disease, providing the reader with essential information on technical assays in artificially created models. It includes background information on individual cardiovascular diseases, describes detailed methods and materials used for establishing each mouse model, discusses the problems that may appear in the experiments, and provides examples of applications of the model. A Handbook of Mouse Models of Cardiovascular Disease: Describes mouse models of all important cardiovascular diseases, including atherosclerosis, atrial fibrillation and thrombosis Features videos of key experimental procedures on the accompanying CD, allowing researchers to learn the techniques by directly watching the whole operational procedure Describes how to establish each experimental model with detailed protocols and tips on dealing with common operational problems Highlights potential applications of each model in areas such as pathogenesis, gene transfer, therapy and pathophysiology This handbook is an invaluable resource for researchers in cardiovascular disease, pathology, physiology, interested in the mechanism of vascular disorders and therapeutic approaches. It is also relevant to clinicians seeking to understand the pathology of cardiovascular disease and the rationale for interventions, and of interest to the pharmaceutical industry and all those involved in drug discovery/development for cardiovascular disease.
| Author | : Qingbo Xu |
| Publisher | : |
| Total Pages | : 360 |
| Release | : 2006-10-28 |
| Genre | : Science |
| ISBN | : 9780470028797 |
Download A Handbook of Mouse Models of Cardiovascular Disease Book in PDF, ePub and Kindle
The availability of well-defined genetic strains and the ability to create transgenic and knockout mice makes mouse models extremely valuable biomedical tools. Their suitability as an experimental system for cardiovascular research depends on the individual investigator’s ability to manipulate the mice surgically. Many mouse models require microsurgical techniques, which hitherto could not be performed without practical training. This comprehensive handbook will enable scientists to develop these models in their own laboratories. It contains detailed advice on the issues that investigators need to consider before starting their experiments. It then provides essential information about experimental procedures, specific instruments and technical knowledge and will prove an indispensable guide to all scientists planning to work with these mouse models. This book includes a brief introduction to each disease, followed by a detailed description of the methods and materials used to establish the relevant mouse model. Each chapter has been written by an expert familiar with that system, who provides helpful discussion of the problems that may be encountered and examples of applications of the model. Importantly, each technique is clearly illustrated on the accompanying CD, so that researchers can observe the operational procedures directly. With coverage of all the major mouse models of cardiovascular disease, this book may be used to obtain a broad overview of commonly used methods and, more importantly, as a comprehensive source of detailed information on the development and study of such models. It will prove essential reading to all those working on experimental animal models of cardiovascular disease, from students to independent investigators.
| Author | : Marten H. Hofker |
| Publisher | : Humana Press |
| Total Pages | : 0 |
| Release | : 2002-08-20 |
| Genre | : Science |
| ISBN | : 9780896039155 |
Download Transgenic Mouse Methods and Protocols Book in PDF, ePub and Kindle
Marten Hofker and Jan van Deursen have assembled a multidisciplinary collection of readily reproducible methods for working with mice, and particularlyfor generating mouse models that will enable us to better understand gene function. Described in step-by-step detail by highly experienced investigators, these proven techniques include new methods for conditional, induced knockout, and transgenic mice, as well as for working with mice in such important research areas as immunology, cancer, and atherosclerosis. Such alternative strategies as random mutagenesis and viral gene transduction for studying gene function in the mouse are also presented.
| Author | : Marten H. Hofker |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 382 |
| Release | : 2008-02-04 |
| Genre | : Science |
| ISBN | : 1592593402 |
Download Transgenic Mouse Methods and Protocols Book in PDF, ePub and Kindle
Marten Hofker and Jan van Deursen have assembled a multidisciplinary collection of readily reproducible methods for working with mice, and particularlyfor generating mouse models that will enable us to better understand gene function. Described in step-by-step detail by highly experienced investigators, these proven techniques include new methods for conditional, induced knockout, and transgenic mice, as well as for working with mice in such important research areas as immunology, cancer, and atherosclerosis. Such alternative strategies as random mutagenesis and viral gene transduction for studying gene function in the mouse are also presented.
| Author | : Robert Fitridge |
| Publisher | : University of Adelaide Press |
| Total Pages | : 589 |
| Release | : 2011 |
| Genre | : Medical |
| ISBN | : 1922064009 |
Download Mechanisms of Vascular Disease Book in PDF, ePub and Kindle
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
| Author | : Rhian M. Touyz |
| Publisher | : Springer |
| Total Pages | : 503 |
| Release | : 2019-08-02 |
| Genre | : Medical |
| ISBN | : 3030164810 |
Download Textbook of Vascular Medicine Book in PDF, ePub and Kindle
This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons. This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease). The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies.
| Author | : Miao Wang |
| Publisher | : Springer Nature |
| Total Pages | : 345 |
| Release | : 2020-04-03 |
| Genre | : Medical |
| ISBN | : 981152517X |
Download Coronary Artery Disease: Therapeutics and Drug Discovery Book in PDF, ePub and Kindle
This book provides an overview of the etiology of coronary artery disease and focuses on the main therapies and drug interventions currently available. It highlights drug pharmacology and therapeutic challenges, with a special emphasis on the underlying principles of available therapeutics and the on-going development of drugs for coronary artery disease. The book is divided into eight chapters, the first of which describes the classical mechanism of coronary artery disease and its clinical presentations. Chapter 2 lists the principles of and related evidence on the prevention and treatment of coronary artery disease. This includes diet and lifestyle management, and guidelines for the treatment of acute coronary syndrome and stable coronary artery disease. In turn, Chapter 3 describes revascularization treatments, covering percutaneous coronary interventions, coronary artery bypass grafts and thrombolysis. This chapter also addresses the main therapeutic challenges. The following chapters provide an overview of three major categories of coronary artery disease drugs, which target thrombosis (Chapter 4), lipid metabolism (Chapter 5), and hypertension (Chapter 6). Heart failure constitutes the major health burden in the late stage of coronary artery disease; accordingly, current heart failure therapeutics and related drug pharmacology are described in Chapter 7. In closing, Chapter 8 provides a summary of on-going clinical trials for coronary artery disease drug development and discusses a number of promising areas in which intensive research into new therapeutics is being pursued. Given its scope, the book will be of interest to clinicians, medical students and research scientists, as well as to pharmaceutical professionals who are seeking new therapies and drugs for coronary artery disease and related disorders.
| Author | : Georg Wick |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 628 |
| Release | : 2011-12-03 |
| Genre | : Medical |
| ISBN | : 370910338X |
Download Inflammation and Atherosclerosis Book in PDF, ePub and Kindle
It has been known for over 150 years that hallmarks of inflammation can be observed in the wall of atherosclerotic vessels. It was, however, not clear if this inflammation is the cause or the consequence of atherogenesis. More recently, it has become evident that inflammation mediated both by innate and adaptive immunity is instrumental even in the earliest stages of the development of atherosclerotic lesions, i.e., that it plays an important pathogenetic role. In this volume, international experts in the field discuss the pathogenetic, diagnostic, preventive and possible therapeutic relevance of inflammation in atherogenesis. This book is intended for researchers and physicians in the fields of vascular biology, immunology and atherosclerosis.
| Author | : Rob Krams |
| Publisher | : Oxford University Press |
| Total Pages | : 347 |
| Release | : 2017 |
| Genre | : Medical |
| ISBN | : 0198755775 |
Download The ESC Textbook of Vascular Biology Book in PDF, ePub and Kindle
The ESC Textbook of Vascular Biology is a rich and clearly laid-out guide by leading European scientists providing comprehensive information on vascular physiology, disease, and research.
