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Measuring Heavy Metal Contaminants in Cannabis and Hemp

Measuring Heavy Metal Contaminants in Cannabis and Hemp
Author: Robert J. Thomas
Publisher: CRC Press
Total Pages: 672
Release: 2020-09-30
Genre: Science
ISBN: 1000193411

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The surge of interest in cannabis-based medicinal products has put an extremely high demand on testing capabilities, particularly for contaminants such as heavy metals, which are naturally taken up through the roots of the plants from the soil, growing medium, and fertilizers but can also be negatively impacted by the grinding equipment and extraction/distillation process. Unfortunately, many state regulators do not have the necessary experience and background to fully understand all the safety and toxicological issues regarding the cultivation and production of cannabis and hemp products on the market today. Measuring Heavy Metal Contaminants in Cannabis and Hemp offers a comprehensive guide to the entire cannabis industry for measuring elemental contaminants in cannabis and hemp. For testing labs, it describes fundamental principles and practical capabilities of ICP-MS and other AS techniques for measuring heavy metals in cannabis. For state regulators, it compares maximum contaminant limits of heavy metals with those for federally regulated pharmaceutical materials. For cultivators and processors, it helps them to better understand the many sources of heavy metals in cannabis. And for consumers of medical cannabis, it highlights the importance of choosing cannabis products that are safe to use. Other key topics include: The role of other analytical techniques for the comprehensive testing of cannabis products Tips to optimize analytical procedures to ensure the highest quality data Guidance on how to characterize elemental contaminants in vaping liquids and aerosols Suggestions on how to reduce errors using plasma spectrochemistry The role of certified reference materials to validate standard methods Easy-to-read sections on instrumental hardware components, calibration and measurement protocols, typical interferences, routine maintenance, and troubleshooting procedures Written with the cannabis testing community in mind, this book is also an invaluable resource for growers, cultivators, processors, testers, regulators, and even consumers who are interested in learning more about the potential dangers of heavy metal contaminants in cannabis and hemp.


Analysis of Cannabis

Analysis of Cannabis
Author:
Publisher: Elsevier
Total Pages: 518
Release: 2020-08-27
Genre: Science
ISBN: 0444643427

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Analysis of Cannabis, Volume 91, contains a wide variety of information on the analysis of cannabis and hemp, including cannabinoids, terpenes, volatile solvents and metals. Specific chapters in this new release include the Comprehensive Analytical Testing of Cannabis and Hemp, Machine Learning Methods for Inferring Chemotype Profiles in Cannabis Sativa, Recent Analytical Methodologies and Strategic Pharmacological Applications of Cannabinoids, Analysis of Cannabinoids in Plants, Marijuana Products and Biological Tissues, LC-based (UV and MS) Analysis of Cannabinoids, Testing Cannabis Samples for Heavy Metal Contamination using Microwave Assisted Digestion and ICP-MS Techniques, Applications of GC-MS Techniques for Cannabis Analysis, and much more. Contains diverse, state-of-the-art methodologies for the analyses of cannabinoids and terpenes in a variety of matrices Analyzes different cannabis and hemp-based products Provides the expertise of leading contributors from an international board of authors


Measuring Elemental Impurities in Pharmaceuticals

Measuring Elemental Impurities in Pharmaceuticals
Author: Robert Thomas
Publisher: CRC Press
Total Pages: 474
Release: 2018-01-29
Genre: Medical
ISBN: 1351984403

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Recent regulations on heavy metal testing have required the pharmaceutical industry to monitor a suite of elemental impurities in pharmaceutical raw materials, drug products and dietary supplements. These new directives s are described in the new United States Pharmacopeia (USP) Chapters , , and , together with Q3D, Step 4 guidelines for elemental impurities, drafted by the ICH (International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use), a consortium of global pharmaceutical associations, including the European Pharmacopeia (Ph.Eur.), the Japanese Pharmacopeia (JP) and the USP. This book provides a complete guide to the analytical methodology, instrumental techniques and sample preparation procedures used for measuring elemental impurities in pharmaceutical and nutraceutical materials. It offers readers the tools to better understand plasma spectrochemistry to optimize detection capability for the full suite of elemental PDE (Permitted Daily Exposure) levels in the various drug delivery categories. Other relevant information covered in the book includes: The complete guide to measuring elemental impurities in pharmaceutical and nutraceutical materials. Covers heavy metals testing in the pharmaceutical industry from an historical perspective. Gives an overview of current USP Chapters and and ICH Q3D Step 4 Guidelines. Explains the purpose of validation protocols used in Chapter , including how J-values are calculated Describes fundamental principles and practical capabilities of ICP-MS and ICP-OES. Offers guidelines about the optimum strategy for risk assessment Provides tips on how best to prepare and present your data for regulatory inspection. An indispensable resource, the fundamental principles and practical benefits of ICP-OES and ICP-MS are covered in a reader-friendly format that a novice, who is carrying out elemental impurities testing in the pharmaceutical and nutraceutical communities, will find easy to understand.


Cannabis sativa L. - Botany and Biotechnology

Cannabis sativa L. - Botany and Biotechnology
Author: Suman Chandra
Publisher: Springer
Total Pages: 479
Release: 2017-05-23
Genre: Science
ISBN: 3319545647

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This book highlights current Cannabis research: its botany, authentication, biotechnology, in vitro propagation, chemistry, cannabinoids biosynthesis, metabolomics, genomics, biomass production, quality control, and pharmacology. Cannabis sativa L. (Family: Cannabaceae) is one of the oldest sources of fiber, food and medicine. This plant has been of interest to researchers, general public and media not only due to its medicinal properties but also the controversy surrounding its illicit use. Cannabis has a long history of medicinal use in the Middle East and Asia, being first introduced as a medicine in Western Europe in the early 19th century. Due to its numerous natural constituents, Cannabis is considered a chemically complex species. It contains a unique class of terpeno-phenolic compounds (cannabinoids or phytocannabinoids), which have been extensively studied since the discovery of the chemical structure of tetrah ydrocannabinol (Δ9-THC), commonly known as THC, the main constituent responsible for the plant’s psychoactive effects. An additionally important cannabinoid of current interest is Cannabidiol (CBD). There has been a significant interest in CBD and CBD oil (extract of CBD rich Cannabis) over the last few years because of its reported activity as an antiepileptic agent, particularly its potential use in the treatment of intractable epilepsy in children.


Phytoremediation Potential of Bioenergy Plants

Phytoremediation Potential of Bioenergy Plants
Author: Kuldeep Bauddh
Publisher: Springer
Total Pages: 482
Release: 2017-03-29
Genre: Technology & Engineering
ISBN: 9811030847

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The globally escalating population necessitates production of more goods and services to fulfil the expanding demands of human beings which resulted in urbanization and industrialization. Uncontrolled industrialization caused two major problems – energy crisis and accelerated environmental pollution throughout the world. Presently, there are technologies which have been proposed or shown to tackle both the problems. Researchers continue to seek more cost effective and environmentally beneficial pathways for problem solving. Plant kingdom comprises of species which have the potential to resolve the couple problem of pollution and energy. Plants are considered as a potential feedstock for development of renewable energy through biofuels. Another important aspect of plants is their capacity to sequester carbon dioxide and absorb, degrade, and stabilize environmental pollutants such as heavy metals, poly-aromatic hydrocarbons, poly-aromatic biphenyls, radioactive materials, and other chemicals. Thus, plants may be used to provide renewable energy generation and pollution mitigation. An approach that could amalgamate the two aspects can be achieved through phytoremediation (using plants to clean up polluted soil and water), and subsequent generation of energy from the phyto-remediator plants. This would be a major advance in achieving sustainability that focuses on optimizing ‘people’ (social issues), ‘planet’ (environmental issues), and ‘profit’ (financial issues). The “Phytoremediation-Cellulosic Biofuels” (PCB) process will be socially beneficial through reducing pollution impacts on people, ecologically beneficial through pollution abatement, and economically viable through providing revenue that supplies an energy source that is renewable and also provides less dependence on importing foreign energy (energy-independence). The utilization of green plants for pollution remediation and energy production will also tackle some other important global concerns like global climate change, ocean acidification, and land degradation through carbon sequestration, reduced emissions of other greenhouse gases, restoration of degraded lands and waters, and more. This book addresses the overall potential of major plants that have the potential to fulfil the dual purposes of phytoremediation and energy generation. The non-edible bioenergy plants that are explored for this dual objective include Jatropha curcas, Ricinus communis, Leucaena leucocephalla, Milletia pinnata, Canabis sativa, Azadirachta indica, and Acacia nilotica. The book addresses all possible aspects of phyto-remediaton and energy generation in a holistic way. The contributors are one of most authoritative experts in the field and have covered and compiled the best content most comprehensively. The book is going to be extremely useful for researchers in the area, research students, academicians and also for policy makers for an inclusive understanding and assessment of potential in plant kingdom to solve the dual problem of energy and pollution.


How Tobacco Smoke Causes Disease

How Tobacco Smoke Causes Disease
Author: United States. Public Health Service. Office of the Surgeon General
Publisher:
Total Pages: 728
Release: 2010
Genre: Government publications
ISBN:

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This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.


Metal Metabolism in Aquatic Environments

Metal Metabolism in Aquatic Environments
Author: William J. Langston
Publisher: Springer Science & Business Media
Total Pages: 480
Release: 2013-06-29
Genre: Science
ISBN: 1475727615

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Metal Metabolism in Aquatic Environments is a synthesis of recent developments in the field of metal ecotoxicology and features a number of contemporary issues arising from the interaction of metals and biota, such as pathways of assimilation and food chain transfer, metal accumulation and detoxification in humans and biotransformation of elements such as mercury and arsenic.


Heavy Metals

Heavy Metals
Author: Mazen Nazal
Publisher: BoD – Books on Demand
Total Pages: 282
Release: 2021-11-03
Genre: Technology & Engineering
ISBN: 1839681217

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In recent years, urbanization and industrialization have produced large amounts of heavy metals, which are highly toxic to both humans and the environment. This book presents a comprehensive overview of heavy metals including their physiochemical properties, toxicity, transfer in the environment, legislation, environmental impacts, and mitigation measures. Written by experts in the field, chapters include scientific research as well as case studies.


Cannabis and Cannabinoids

Cannabis and Cannabinoids
Author: Ethan B Russo
Publisher: Routledge
Total Pages: 482
Release: 2013-09-05
Genre: Health & Fitness
ISBN: 1136614931

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Study the latest research findings by international experts! This comprehensive volume presents state-of-the-art scientific research on the therapeutic uses of cannabis and its derivatives. All too often, discussions of the potential medical uses of this substance are distorted by political considerations that have no place in a medical debate. Cannabis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential features fair, equitable discussion of this emerging and controversial medical topic by the world’s foremost researchers. Cannabis and Cannabinoids examines the benefits, drawbacks, and side effects of medical marijuana as a treatment for various conditions and diseases. This book discusses the scientific basis for marijuana’s use in cases of pain, nausea, anorexia, and cachexia. It also explores its possible benefits in glaucoma, ischemia, spastic disorders, and migraine. Cannabis and Cannabinoids examines all facets of the medical use of marijuana, including: botany history biochemistry pharmacology clinical use toxicology side effects Cannabis and Cannabinoids is a reference work that will become indispensable to physicians, psychologists, researchers, biochemists, graduate students, and interested members of the public. No other book available offers this comprehensive, even-handed look at a deeply divisive subject.