Mass Spectrometry In Drug Metabolism And Disposition PDF Download
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Author | : Mike S. Lee |
Publisher | : John Wiley & Sons |
Total Pages | : 648 |
Release | : 2011-03-16 |
Genre | : Science |
ISBN | : 0470934697 |
Download Mass Spectrometry in Drug Metabolism and Disposition Book in PDF, ePub and Kindle
This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text.
Author | : Frigerio |
Publisher | : Springer Science & Business Media |
Total Pages | : 527 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 1461341515 |
Download Mass Spectrometry in Drug Metabolism Book in PDF, ePub and Kindle
When a dose of drug is administered, three main phases of drug action may be distingushed. In the "pharmaceutical" phase the dosage form disintegrates, the active substance dissolves and becomes available for absorption. The second phase ("pharmaco kinetic" phase) includes absorption, distribution, metabolism, and excretion. That fraction of the dose which finally reaches the circulation after absorption will be available for biological action in the third, or "pharmacodynamic" phase when the drug reaches the target tissues and a drug-receptor interaction takes place. The objectives in studies of drug metabolism are: (a) to identify the pathways by which drugs are transformed in the body; (b) to ascertain quantitatively the importance of each pathway and intermediate; (c) to identify and quantify endogenous constituents influenced by the drug or its metabolites which may interfere with common metabolic processes. Since metabolites usually differ from their precursors by only a single chemical group, the resulting metabolic pathways generally consist of a series of closely related compounds. Mass spectrometry is uniquely suited for the analysis of drugs and metabolites for several reasons: only a minimal amount of sample preparation is needed, closely related compounds can be analyzed in a single step, structures can often be deduced directly from the mass spectra without the need for pure reference spectra, and constituents can be quantified with relative ease even when present in fractional nanogram quantity.
Author | : Ragu Ramanathan |
Publisher | : John Wiley & Sons |
Total Pages | : 326 |
Release | : 2011-09-20 |
Genre | : Science |
ISBN | : 111821157X |
Download Mass Spectrometry in Drug Metabolism and Pharmacokinetics Book in PDF, ePub and Kindle
This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics. Highlighting the critical importance of ADME studies for understanding how a drug is absorbed, distributed, metabolized, and excreted by the body, the book s focuses on the use of LC/MS and MALDI-MS. This is a valuable reference for scientists in the pharmaceutical industry, medicine, academia, and even those working in homeland defense.
Author | : Alberto Frigerio |
Publisher | : |
Total Pages | : 0 |
Release | : 1976 |
Genre | : Drug abuse |
ISBN | : |
Download Mass Spectrometry in Drug Metabolism Book in PDF, ePub and Kindle
Author | : Walter A. Korfmacher |
Publisher | : CRC Press |
Total Pages | : 442 |
Release | : 2009-11-03 |
Genre | : Medical |
ISBN | : 1420092219 |
Download Using Mass Spectrometry for Drug Metabolism Studies Book in PDF, ePub and Kindle
The first edition of this now classic work helped to establish mass spectrometry as the premier tool for drug metabolism studies. Completely rewritten from start to finish, Using Mass Spectrometry for Drug Metabolism Studies, Second Edition brings medicinal chemists and mass spectrometry professionals up to speed with the rapid advances in the fiel
Author | : James Paxton |
Publisher | : BoD – Books on Demand |
Total Pages | : 310 |
Release | : 2012-02-22 |
Genre | : Medical |
ISBN | : 9535100998 |
Download Topics on Drug Metabolism Book in PDF, ePub and Kindle
In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and metabolism in oral bioavailability; the influence of genetic and epigenetic factors on drug metabolism; impact of disease on transport and metabolism; and the use of novel microdosing techniques and novel LC/MS and genomic technologies to predict the metabolic parameters and profiles of potential new drug candidates.
Author | : Donglu Zhang |
Publisher | : John Wiley & Sons |
Total Pages | : 448 |
Release | : 2007-11-16 |
Genre | : Science |
ISBN | : 9780470191682 |
Download Drug Metabolism in Drug Design and Development Book in PDF, ePub and Kindle
The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. With chapters contributed by experts in their specific areas, this reference covers: * Basic concepts of drug metabolism * The role of drug metabolism in the pharmaceutical industry * Analytical techniques in drug metabolism * Common experimental approaches and protocols Drug Metabolism in Drug Design and Development emphasizes practical considerations such as the data needed, the experiments and analytical methods typically employed, and the interpretation and application of data. Chapters highlight facts, common protocols, detailed experimental designs, applications, and limitations of techniques. This is a comprehensive, hands-on reference for drug metabolism researchers as well as other professionals involved in pre-clinical drug discovery and development.
Author | : 3Island Press |
Publisher | : |
Total Pages | : 550 |
Release | : 1977-03-01 |
Genre | : |
ISBN | : 9781461341529 |
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Author | : Hye Suk Lee |
Publisher | : MDPI |
Total Pages | : 230 |
Release | : 2019-06-12 |
Genre | : Medical |
ISBN | : 3038979163 |
Download Drug Metabolism, Pharmacokinetics and Bioanalysis Book in PDF, ePub and Kindle
Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.
Author | : David T. Rossi |
Publisher | : CRC Press |
Total Pages | : 436 |
Release | : 2001-11-07 |
Genre | : Medical |
ISBN | : 9781420002478 |
Download Mass Spectrometry in Drug Discovery Book in PDF, ePub and Kindle
Mass Spectrometry in Drug Discovery summarizes the theory, instrumentation, techniques, and application of mass spectrometry and atmospheric pressure ionization to screening, evaluating, and improving the performance and quality of drug candidates. It provides time- and cost-efficient approaches for the generation and analysis of effective pharmaceuticals, covers advances in combinatorial chemistry, molecular biology, bioanalysis automation, and computing, and demonstrates the use of mass spectrometry in the assessment of disease states, drug targets, and potential drug agents.