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| Author | : Christopher J. Barker |
| Publisher | : Humana |
| Total Pages | : 260 |
| Release | : 2010-05-27 |
| Genre | : Science |
| ISBN | : |
This text introduces the basic methodological tools to measure inositol lipids and phosphates and also describes new approaches that have become available in the last ten years, including g RNA-silencing and the protocols involving inositol pyrophosphates.
| Author | : A. Kuksis |
| Publisher | : Elsevier |
| Total Pages | : 1001 |
| Release | : 2003-09-12 |
| Genre | : Science |
| ISBN | : 0080930301 |
This book offers a wide ranging and review of cutting edge developments along with tried and tested methods for isolation, resolution and quantification of inositol phospholipids and inositol polyphosphates in both cells and tissues. It includes detailed and rigorous methodology for identification of molecular species of inositol phospholipids, including their phosphates and glycans, with numerous examples of specific applications. Wherever available, both chromatographic and mass spectrometric evidence is presented for specific phospholipid involvement in the biochemical transformations accompanying metabolic signalling events and, where possible, controversies have been resolved on basis of analytical ambiguity. The review of the lipid analyses extends to products of phosphatidylinositol kinases, phosphatases and lipases. A general review chapter is included on metabolic signalling with special emphasis on the lipid products of 3-kinases. In view of the general lack of commercially available standards for inositol phospholipids and inositol phosphates, the book concludes with a chapter on the preparation and collection of chromatographic and mass spectrometric proof of their purity and identity. This book complements recent books and reviews on the mechanisms metabolic signalling, receptor binding and the polypeptide structure of the proteins involved in the various signalling pathways. It also complements those texts that deal exclusively with the chemical synthesis of the phosphatidylinositols and their polyphosphates and glycans.
| Author | : R. H. Michell |
| Publisher | : |
| Total Pages | : 568 |
| Release | : 1989 |
| Genre | : Science |
| ISBN | : |
The discovery that inositol lipids are integral in cellular signaling mechanisms has been one of the most exciting breakthroughs in recent years. As secondary messengers in a wide variety of tissues and involved processes as diverse as rapid contraction of skeletal muscle, insulin secretion, and the slow activation of cell proliferation in cancer cells, their impact on biochemistry is akin to that of cyclic AMP two decades ago. Drawing together the many strands of research on inositol lipid-mediated signalling and containing contributions by leading authorities in their fields, Inositol Lipids in Cell Signalling is essential for any involved biochemist, cell biologist, or pharmacologist.
| Author | : John N. Fain |
| Publisher | : Academic Press |
| Total Pages | : 376 |
| Release | : 2013-10-22 |
| Genre | : Science |
| ISBN | : 1483288323 |
Many of the phospholipases and even the receptor for inositol 1,4,5-trisphosphate have recently been cloned and sequenced and play an important role in neurotransmission. Methods developed in recent years for the study of the enzymes and intermediates involved in the regulation of neuronal signal transduction involving phospholipid turnover are presented in this volume. Techniques for examining the role of phosphoinositides in signal transduction Techniques related to protein kinase C Analysis of inositol phosphates Techniques to analyze phospholipid turnover in the brain
| Author | : R. H. Michell |
| Publisher | : Cold Spring Harbor Laboratory Press |
| Total Pages | : 184 |
| Release | : 1987 |
| Genre | : Biochemistry |
| ISBN | : |
| Author | : Michael J. O. Wakelam |
| Publisher | : Portland Press |
| Total Pages | : 277 |
| Release | : 2007-01-01 |
| Genre | : Medical |
| ISBN | : 9781855781665 |
The Cell Biology of Inositol Lipids and Phosphates is the published proceedings of the Biochemical Society's Annual Symposium held at the University of Birmingham on 29-31 March 2006, which featured presentations from international experts from across the field of cell signalling who have contributed to this volume. contribution to the field.
| Author | : Jamie Alistair Stuart |
| Publisher | : |
| Total Pages | : |
| Release | : 1995 |
| Genre | : |
| ISBN | : |
| Author | : B.B. Biswas |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 433 |
| Release | : 2013-11-11 |
| Genre | : Science |
| ISBN | : 1461303435 |
`The heterogeneity of topics ... is very ambitious, and the result is, overall, successful because of the high quality of the individual contributions ... highly recommended.' -American Scientist, from a review of a previous volume Volume 26 examines the emerging areas of signal transduction based on myoinositol phosphates and Ca2+ while focusing on plant and animal responses. Chapters explore synthesis, separation, and identification of different inositol phosphates.
| Author | : Bruce Alberts |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2002 |
| Genre | : Cytology |
| ISBN | : 9780815332183 |
| Author | : John E. Bleasdale |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 690 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 1461251842 |
The Chilton Conference on Inositol and Phosphoinositides, held on January 9-11, 1984 at Southwestern Medical School, University of Texas Health Science Center, Dallas, Texas, was the third in a series of conferences on cyclitols and phosphoinositides. The first took place in 1968 in New York [Ann. New York Acad. Sci. (1969), 765,508-819] and the second was held in 1977 in East Lansing, Michigan [eyclitols and Phosphoinositides, Wells, W. W. and Eisenberg, F. , eds. , (1978) Academic press, New York, pp. 1-607. ] In the interim since the previous conference, not only has the pace of research in the field accelerated markedly, but the physiological importance of phosphoinositide metabolism has become apparent to an increasing number of investigators from diverse fields in the life sciences. Thus it seemed to us timely for both recent and established workers in this area, as well as others whose interests impinged on it, to meet in order to disseminate new information, to review, and perhaps arrive at, a consensus of our current understanding of the role of inositol and phosphoinositides, and to establish new directions for research for the next few years. The expansion of the field since the last meeting made it mandatory to restrict the scope of the topics covered at the conference, primarily to aspects dealing with mammalian systems. We sincerely regretted the exclusion of recent research on cyclitols and phosphoinositides in microbes and plants and hope that these areas will be included in future conferences.
