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| Author | : Jeffrey Bland |
| Publisher | : |
| Total Pages | : 242 |
| Release | : 1998 |
| Genre | : |
| ISBN | : |
| Author | : Deliminda Neves |
| Publisher | : John Wiley & Sons |
| Total Pages | : 427 |
| Release | : 2015-04-22 |
| Genre | : Technology & Engineering |
| ISBN | : 1118823249 |
Ageing is a complex, time-related biological phenomenon that is genetically determined and environmentally modulated. According to even the most pessimistic projections, average lifespan is expected to increase around the world during the next 20 years, significantly raising the number of aged individuals. But increasing life expectancy presents new problems, and industrialized countries are facing a pronounced increase in lifestyle diseases which constitute barriers to healthy ageing. Anti-Ageing Nutrients: Evidence-based Prevention of Age-Associated Diseases is written by a multi-disciplinary group of researchers, all interested in the nutritional modulation of ageing mechanisms. Structured in three parts, Part 1 looks at the cellular modifications that underlie senescence of cells and ageing of the organisms; the effects of energy restriction on cellular and molecular mechanisms and in the whole organism; and the epigenetic modifications associated with ageing. Part 2 includes chapters which discuss the nutritional modulation of age-associated pathologies and the functional decline of organs, with a focus on those primarily affected by chronological ageing. Part 3 summarises the knowledge presented in the previous chapters and considers the best diet pattern for the aged individuals. The book reflects the most recent advances in anti-ageing nutrition and will be a valuable resource for professionals, educators and students in the health, nutritional and food sciences.
| Author | : David R. Riddle |
| Publisher | : CRC Press |
| Total Pages | : 408 |
| Release | : 2007-04-19 |
| Genre | : Medical |
| ISBN | : 9781420005523 |
Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur
| Author | : Lavida Rashida Kenera Rogers |
| Publisher | : |
| Total Pages | : 269 |
| Release | : 2019 |
| Genre | : Electronic dissertations |
| ISBN | : 9781085720663 |
Physiological changes with age such as immune system decline and brain aging cause an increased risk for diseases. Age-related diseases are of major concern especially in the elderly population due to there being an increase in the average lifespan. This dissertation explores neurodegenerative and respiratory diseases and how gene expression varies due to disease status, age tissue and sex.Alzheimer's disease (AD) has been categorized by the Centers for Disease Control and Prevention (CDC) as the 6th leading cause of death in the United States. AD is a significant health-care burden because of its increased occurrence (specifically in the elderly population), and the lack of effective treatments and preventive methods. AD targets neuronal function and can cause neuronal loss due to the buildup of amyloid-beta plaques and intracellular neurofibrillary tangles.The respiratory disease, chronic obstructive pulmonary disease (COPD), was classified by the Centers for Disease Control and Prevention in 2014 as the 3rd leading cause of death in the United States. The main cause of COPD is exposure to tobacco smoke and air pollutants. In addition to exploring genetic variation due to disease state, sex and age we also explored the role of smoking status on expression profiles.Additionally, the respiratory infections, influenza and pneumonia affect thousands of people worldwide. Young children, elderly and immunocompromised individuals are at higher risk for being infected by the influenza virus and Streptococcus pneumoniae. Host responses to these pathogens and vaccinations vary by the state of one's immune system.This dissertation includes multiple meta-analyses to assess genetic variation in Alzheimer's disease, COPD and Influenza, and an assessment of pneumococcal disease and aging. To identify significant differentially expressed genes we ran an analysis of variance with a linear model with disease state, age, sex, tissue, smoking status and study as effects that also included binaryinteractions.Our meta-analysis approach effectively combined multiple publicly available microarray datasetsto identify gene expression differences across diseases including full age, sex, smoking status and tissue type considerations. Our findings provide potential gene and pathway associations that can be targeted to improve treatment and prevention of diseases.
| Author | : Trygve O. Tollefsbol |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 462 |
| Release | : 2009-11-11 |
| Genre | : Medical |
| ISBN | : 1441906398 |
Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.
| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 385 |
| Release | : 2006-12-07 |
| Genre | : Social Science |
| ISBN | : 0309101964 |
Over the past century, we have made great strides in reducing rates of disease and enhancing people's general health. Public health measures such as sanitation, improved hygiene, and vaccines; reduced hazards in the workplace; new drugs and clinical procedures; and, more recently, a growing understanding of the human genome have each played a role in extending the duration and raising the quality of human life. But research conducted over the past few decades shows us that this progress, much of which was based on investigating one causative factor at a time—often, through a single discipline or by a narrow range of practitioners—can only go so far. Genes, Behavior, and the Social Environment examines a number of well-described gene-environment interactions, reviews the state of the science in researching such interactions, and recommends priorities not only for research itself but also for its workforce, resource, and infrastructural needs.
| Author | : Larry Trivieri |
| Publisher | : Celestial Arts |
| Total Pages | : 1280 |
| Release | : 2013-03-27 |
| Genre | : Health & Fitness |
| ISBN | : 1587613867 |
The "Bible" of Alternative Medicine Learn the health secrets that millions of readers have discovered in the book that is revolutionizing health care in the United States. Alternative Medicine: The Definitive Guide is packed with lifesaving information and alternative treatments from 400 of the world's leading alternative physicians. Our contributors (M.D.s, Ph.D.s, Naturopaths, Doctors of Oriental Medicine, and Osteopaths) offer the safest, most affordable, and most effective remedies for over 200 serious health conditions, from cancer to obesity, heart disease to PMS. This guide is easy enough to understand to make it perfect for home reference, while it would also make a fine resource for health care providers interested in learning more about alternative medicine. • 70% of Americans currently use some form of alternative medicine • This 1,136-page encyclopedia puts all the schools of alternative medicine-50 different therapies-under one roof • Highlights dozens of actual patient stories and physician treatments.
| Author | : Panel on New Directions in Social Demography, Social Epidemiology, and the Sociology of Aging |
| Publisher | : National Academies Press |
| Total Pages | : 301 |
| Release | : 2014-01-09 |
| Genre | : Social Science |
| ISBN | : 9780309292979 |
The aging of the population of the United States is occurring at a time of major economic and social changes. These economic changes include consideration of increases in the age of eligibility for Social Security and Medicare and possible changes in benefit levels. Furthermore, changes in the social context in which older individuals and families function may well affect the nature of key social relationships and institutions that define the environment for older persons. Sociology offers a knowledge base, a number of useful analytic approaches and tools, and unique theoretical perspectives that can facilitate understanding of these demographic, economic, and social changes and, to the extent possible, their causes, consequences and implications. The Future of the Sociology of Aging: An Agenda for Action evaluates the recent contributions of social demography, social epidemiology and sociology to the study of aging and identifies promising new research directions in these sub-fields. Included in this study are nine papers prepared by experts in sociology, demography, social genomics, public health, and other fields, that highlight the broad array of tools and perspectives that can provide the basis for further advancing the understanding of aging processes in ways that can inform policy. This report discusses the role of sociology in what is a wide-ranging and diverse field of study; a proposed three-dimensional conceptual model for studying social processes in aging over the life cycle; a review of existing databases, data needs and opportunities, primarily in the area of measurement of interhousehold and intergenerational transmission of resources, biomarkers and biosocial interactions; and a summary of roadblocks and bridges to transdisciplinary research that will affect the future directions of the field of sociology of aging.
| Author | : Larry Trivieri, Jr. |
| Publisher | : Random House Digital, Inc. |
| Total Pages | : 1265 |
| Release | : 2002 |
| Genre | : Health & Fitness |
| ISBN | : 1587611414 |
21st Century Science Collection.
| Author | : Vincent C. Giampapa |
| Publisher | : CRC Press |
| Total Pages | : 310 |
| Release | : 2022-09-01 |
| Genre | : Science |
| ISBN | : 1000794555 |
This book takes a whole new perspective concerning the approach to treating aging process. Most doctors feel they have no other options but to operate on the physical processes that occur as we grow older. Now, for the first time, there is another scientific approach that impacts on the causes of aging and not just on the effects.
