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Immunotherapies Towards HIV Cure

Immunotherapies Towards HIV Cure
Author: Carolina Garrido
Publisher: Frontiers Media SA
Total Pages: 153
Release: 2021-07-08
Genre: Science
ISBN: 2889669815

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HIV-1 Latency

HIV-1 Latency
Author: Guido Silvestri
Publisher: Springer
Total Pages: 248
Release: 2018-10-11
Genre: Medical
ISBN: 303002816X

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This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.


HIV Vaccines and Cure

HIV Vaccines and Cure
Author: Linqi Zhang
Publisher: Springer
Total Pages: 318
Release: 2018-07-20
Genre: Medical
ISBN: 981130484X

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This book provides a comprehensive review of the major barriers to HIV cure and vaccine. It covers the fundamental virology and immunology leading to HIV transmission, protection from infection and long term HIV persistence on antiretroviral therapy. In addition, strategies being tested to eliminate persistent HIV and the rational design of vaccines to induce protective immunity are covered. This book also discusses the challenges related to the design of clinical trials for testing the safety and efficacy of these innovative approaches. This book will provide a systematic overview and also discuss controversial issues for researchers in virology and immunology, as well as practicing physicians, and scientists in the pharmaceutical industry.


Lymph Node T Cell Dynamics and Novel Strategies for HIV Cure

Lymph Node T Cell Dynamics and Novel Strategies for HIV Cure
Author: Constantinos Petrovas
Publisher: Frontiers Media SA
Total Pages: 186
Release: 2019-02-11
Genre:
ISBN: 2889457583

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Currently, more than 36 million people are infected with HIV. Although the introduction of highly active anti-retroviral therapy (HAART) has led to substantial advances in the clinical management of HIV infected individuals, HAART cannot completely eliminate the virus. This is because CD4 T helper cells, harboring the virus, remain dormant reservoirs. These reservoirs are difficult to measure and are present even in HAART-treated HIV infected individuals with undetectable levels of HIV in the blood. A growing body of studies has revealed follicular helper (Tfh) CD4 T cells, a highly differentiated CD4 T cell population localized in immunologically sanctuary sites (follicle/germinal center), as a major reservoir of HIV. The present Frontiers in Immunology eBook compiles 16 timely review articles focusing on the dynamics of major follicular immune cell types in HIV/SIV infection and their potential role for disease pathogenesis and the viral persistence in the lymph node. This eBook provides a comprehensive presentation of recent published work on lymph node and especially Tfh cell dynamics in HIV infection and we hope that it will be useful for our further understanding of how such dynamics affect the interplay between virus and host as well as for the discovery of novel therapeutic targets in the fight against HIV.


Immunotreatment and Gene Therapy of HIV Infection

Immunotreatment and Gene Therapy of HIV Infection
Author: Ulrich R. Hengge
Publisher:
Total Pages: 144
Release: 2004
Genre:
ISBN: 9783895997020

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Tremendous progress in the understanding of the immune pathogenesis of HIV disease has been made in the last two decades like in no other field of science ever before. Besides the inhibition of viral replication with highly active antiretroviral therapy (HAART) immunoreconstitution remains an important mainstay to be achieved in the battle against HIV. Intensive research has led to worldwide phase-III studies of immunotreatment of HIV infection such as the SILCAAT and ESPRIT trials to boost existing immune responses and to restore the immune system leading to the control of viral replication. The science and practical management of immunotherapy of HIV patients is described by famous experts from immunology, virology, gene therapy, dermatology, and clinical medicine.


Hiv/AIDS

Hiv/AIDS
Author: Kayleigh Lee
Publisher: Independently Published
Total Pages: 0
Release: 2024-01-30
Genre: Health & Fitness
ISBN:

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Struggling with the daily grind of HIV treatment and care? Feeling overwhelmed trying to make sense of the dizzying array of emerging science around finding a cure? You're not alone. That's why I wrote this helpful guidebook demystifying all the latest advances toward better therapies and maybe even one day ending HIV for good. Inside, you'll find a comprehensive yet readable overview of virtually every major branch of current HIV research translated clearly for non-scientists. I walk you step-by-step through exciting new approaches, like using gene editing technologies to snip out HIV from infected cells. Or powering up the immune system's natural defenses with custom-designed vaccines and supercharged cells. You'll discover promising new long-acting treatments on the horizon that may finally free patients from daily medication routines. And you'll learn how scientists creatively combine multiple cutting-edge platforms to help control the virus. Along the way, my goal is to educate and inspire fresh hope by revealing all the remarkable innovation emerging from labs worldwide. I peel back the curtain so you can appreciate the intricate coordination evolving across diverse fields - from immunotherapy to nanomedicine to curative stem cell transplantation. Whether you're newly diagnosed or an HIV health advocate, this guide aims to be a trusted knowledge base answering your questions and a reassuring companion rekindling motivation during the toughest moments. Because knowing the brightest scientific minds wake up working to improve our futures every day is reason enough not to lose hope. The journey is long but progress continues.


Disease Control Priorities, Third Edition (Volume 6)

Disease Control Priorities, Third Edition (Volume 6)
Author: King K. Holmes
Publisher: World Bank Publications
Total Pages: 1027
Release: 2017-11-06
Genre: Medical
ISBN: 1464805253

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Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.