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Eicosanoids in Invertebrate Signal Transduction Systems

Eicosanoids in Invertebrate Signal Transduction Systems
Author: David W. Stanley
Publisher: Princeton University Press
Total Pages: 290
Release: 2014-07-14
Genre: Science
ISBN: 1400865050

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This volume generates a new paradigm for researching and understanding the biological meaning of eicosanoids. Eicosanoid is a general term for oxygenated metabolites of certain polyunsaturated fatty acids. The compounds are extremely important in human biology, in which they are well understood. Their importance to humans, however, has tended to overshadow their broader biological significance. David Stanley seeks to change that in this book, providing a general sketch of the medical background on eicosanoids and then developing a detailed critical treatment of eicosanoid actions in invertebrates and some lower vertebrates. Stanley looks at the role of eicosanoids in, for example, invertebrate reproduction, immunity, and ion transport physiology. As he explains, eicosanoids also mediate important ecological interactions, particularly host-parasite interactions. Drawing on these physiological and ecological actions, the book develops a "biological paradigm," under which we understand that eicosanoids probably exert important actions in most, if not all, animals. Because eicosanoids mediate crucial events in the lives of animals, they are endowed with unusual explanatory power. Research designed to increase our understanding of eicosanoids has thus yielded and will continue to yield important new information about animal biology. In addition to representing a major advance in our understanding of eicosanoids in animals, this book serves as an unusually comprehensive and accessible introduction to eicosanoid research in general. Originally published in 1999. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.


The Characterization of Sulfidopeptide Leukotriene Actions on Distal Colonic Ion Transport and Smooth Muscle Contractility and Their Possible Involvement in Acute Experimentally-induced Colitis in the Guinea Pig

The Characterization of Sulfidopeptide Leukotriene Actions on Distal Colonic Ion Transport and Smooth Muscle Contractility and Their Possible Involvement in Acute Experimentally-induced Colitis in the Guinea Pig
Author: David Marshall Hammerbeck
Publisher:
Total Pages: 324
Release: 1992
Genre:
ISBN:

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Eicosanoid Protocols

Eicosanoid Protocols
Author: Elias A Lianos
Publisher: Springer Science & Business Media
Total Pages: 298
Release: 2008-02-03
Genre: Science
ISBN: 1592592635

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In Eicosanoid Protocols, Elias A. Lianos and a panel of hands-on experts present cutting-edge methods for the study of eicosanoids, including prostaglandins, thromboxanes, and leukotrienes. The readily reproducible methods described hereconcentrate on studying the regulation of expression and function of enzymes, particularly cyclooxygenase (and its two isoforms), phospholipase A2, and lipoxygenases involved in the synthesis of established eicosanoids. Additional chapters are devoted to the characterization and distribution of the thromboxane A2 receptor in tissues and the biological roles of novel eicosanoids. Timely and authoritative, the methods in this book will help their users in exploring the pathobiology of inflammation. Eicosanoid Protocols offers new and established researchers powerful, state-of-the-art tools to probe the regulation and function of eicosanoids.


Intestinal Water and Electrolyte Transport in Health and Disease

Intestinal Water and Electrolyte Transport in Health and Disease
Author: Mrinalin Rao
Publisher: Biota Publishing
Total Pages: 118
Release: 2012-01-12
Genre: Medical
ISBN: 1615041575

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The unique architecture and physiology of the mammalian intestine, together with a tightly coordinated regulatory system, allows for the handling and absorption of as much as 9 L of fluid a day with 98% or greater efficiency. Advances in the past 40 years have made inroads into revealing the intricacies and interplay of numerous ion transporters and their modulators that are responsible for intestinal electrolyte and water transport. Studies of two devastating diseases, the virulent infectious disease cholera and the autosomal recessive disease cystic fibrosis, were largely responsible for this information explosion. These advances have been critical in the development of new therapeutic strategies to combat life-threatening diseases of varying etiologies ranging from enteric infections to cystic fibrosis and inflammatory bowel diseases. Yet, the story is far from complete, and progress needs to continue on translating information gained from reductionistic cell and tissue culture models, in vivo models, and ultimately human studies and on improving therapeutic approaches. This book reviews the current status of our knowledge of fluid transport across the intestine, including the complexities of transcellular and paracellular ion transport down the length of the intestine and how aberrations of normal physiological processes lead to disease. Table of Contents: Overview / Epithelial Cell and Tissue Architecture / Principles of Transepithelial Electrolyte and Water Movement / Intestinal Architecture and Electrolyte Transport / Electrolyte Transporters--Pumps, Carriers, and Channels / Water Transport / Regulation / Intestinal Disorders and Advances Toward Better Treatment of Intestinal Disorders / Conclusion / References


The Eicosanoids

The Eicosanoids
Author: Peter Curtis-Prior
Publisher: John Wiley & Sons
Total Pages: 654
Release: 2004-07-16
Genre: Medical
ISBN: 047002061X

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This comprehensive reference work, updated from the first edition, brings together the knowledge and expertise of contributors from around the world. It includes new topics such as prostaglandin synthetase enzyme, new synthetic eicosanoids, innovative analytical methods, the influence of cytokines in the regulation of synthesis and actions, newer eicosanoids that influence the cardiovascular system, and newly discovered roles in reproduction and interactions with nitric oxide. This book satisfies a surge of interest in prostaglandins—NSAIDS (e.g. aspirin) are the biggest selling drugs of all time, and the field has been refreshed by the advent of new types (selective COX-2 inhibitors, anti-leukotiene drugs).


Insect Lipids

Insect Lipids
Author: David Warren Stanley
Publisher: U of Nebraska Press
Total Pages: 492
Release: 1993-01-01
Genre: Science
ISBN: 9780803235243

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Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research

Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research
Author: Helmut Sinzinger
Publisher: Springer Science & Business Media
Total Pages: 480
Release: 1997
Genre: Medical
ISBN: 9780306457760

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One hundred papers treat advances in research of the effects and uses of prostaglandins, thromboxanes, and leukotrienes in such medical fields as organ transplantation, male erectile dysfunction, amniotic fluid infection and labour, renal function, anti-inflammatory drugs, allergic and aspirin-intolerant asthma, angioplasty and heart ischemia, Alzheimer's disease, vessel wall hyperplasia, and more. Annotation copyrighted by Book News, Inc., Portland, OR


Eicosanoids and the Skin

Eicosanoids and the Skin
Author: Thomas Ruzicka
Publisher: CRC Press
Total Pages: 230
Release: 1990-03-30
Genre: Medical
ISBN: 9780849360329

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This publication summarizes the increasing knowledge in eicosanoid research. It provides a detailed overview of this rapidly expanding field. The text contains sections on general aspects of arachidonic acid metabolism, the role of eicosanoids in skin diseases, and their biological and biochemical effects in skin. Also included is a section on inhibitors of arachidonic acid metabolism with particular reference to use in dermatology. New concepts covered are: possible physiological role of lipoxygenase products in cutaneous wound healing, restoration and maintenance of cutaneous integrity, and the recently recognized protective function of prostaglandins in skin. It is an invaluable resource for individuals involved with dermatology, pharmacology, inflammation, immunology, biochemistry, physiology, internal medicine and therapeutics.


Biochemistry of the Eye

Biochemistry of the Eye
Author: Elaine R. Berman
Publisher: Springer Science & Business Media
Total Pages: 489
Release: 2013-11-22
Genre: Science
ISBN: 147579441X

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My first introduction to the eye came more than three decades ago when my close friend and mentor, the late Professor Isaac C. Michaelson, convinced me that studying the biochemistry of ocular tissues would be a rewarding pursuit. I hastened to explain that I knew nothing about the subject, since relatively few basic biochemical studies on ocular tissues had appeared in the world literature. Professor Michaelson assured me, however, that two books on eye biochemistry had already been written. One of them, a beautiful monograph by Arlington Krause ( 1934) of Johns Hopkins Hospital, is we II worth reading even today for its historical perspective. The other, published 22 years later, was written by Antoinette Pirie and Ruth van Heyningen ( 1956), whose pioneering achievements in eye biochemistry at the Nuffield Laboratory of Ophthalmology in Oxford, England are known throughout the eye research community and beyond. To their credit are classical investigations on retinal, corneal, and lens biochemistry, beginning in the 1940s and continuing for many decades thereafter. Their important book written in 1956 on the Biochemistry of the Eye is a volume that stood out as a landmark in this field for many years. In recent years, however, a spectacular amount of new information has been gener ated in ocular biochemistry. Moreover, there is increasing specialization among investiga tors in either a specific field of biochemistry or a particular ocular tissue.


Lipid Mediators and Their Metabolism in the Brain

Lipid Mediators and Their Metabolism in the Brain
Author: Akhlaq A. Farooqui
Publisher: Springer Science & Business Media
Total Pages: 344
Release: 2011-08-12
Genre: Medical
ISBN: 144199940X

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Lipid Mediators and Their Metabolism in the Brain presents readers with cutting edge and comprehensive information not only on the synthesis and degradation of glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators, but also their involvement in neurological disorders. It is hoped that this monograph will be useful not only to postgraduate student and their teachers, but also to research scientists and physicians, who are curious about the generation and roles of lipid mediators in the brain.