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Hormones, Cognition and Dementia

Hormones, Cognition and Dementia
Author: Eef Hogervorst
Publisher: Cambridge University Press
Total Pages: 293
Release: 2009-09-24
Genre: Medical
ISBN: 0521899370

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Basic and clinical research on sex steroids, ageing, and cognition to integrate existing findings with emerging data.


Hormones, Cognition, and Dementia

Hormones, Cognition, and Dementia
Author: Eef Hogervorst
Publisher:
Total Pages: 296
Release: 2014-05-14
Genre: Medical
ISBN: 9780511635267

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Basic and clinical research on sex steroids, ageing, and cognition to integrate existing findings with emerging data.


Hormone Therapy and the Brain

Hormone Therapy and the Brain
Author: Victor W. Henderson
Publisher: CRC Press
Total Pages: 120
Release: 1999-10-15
Genre: Medical
ISBN: 9781850700784

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Written by an acknowledged leader in the field, this is a vital clinical reference on the influence of estrogen replacement therapy on Alzheimer's disease, visual dementia, stroke, disorders of movement, epilepsy, migraine headache, and multiple sclerosis. It opens with introductory information and an overview of estrogen and the brain and with coverage of the mechanisms of estrogen action on the brain and the neuroprotective effects of estrogen. Two sections cover the effects of estrogen replacement therapy on mood behavior and cognition and a major section focuses on Alzheimer's disease and other dementias. Another key section covers other neurological disorders, including stroke prevention after menopause, stroke protection in men, neuroprotection after stroke, movement disorders, epilepsy, migraine headache, and multiple sclerosis. Includes color illustrations, bibliographic references and index.


Hormone Replacement Therapy and Cognition

Hormone Replacement Therapy and Cognition
Author: U. S. Department of Health and Human Services
Publisher: CreateSpace
Total Pages: 90
Release: 2013-06-28
Genre: Medical
ISBN: 9781490565668

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In this systematic evidence review, we evaluate data on the use of hormone replacement therapy (HRT) to prevent cognitive decline and dementia in healthy postmenopausal women. Specifically, we reviewed the literature reporting effects of HRT on cognitive function in women without dementia. In addition, we conducted a review and meta-analysis of studies of HRT and dementia, focusing on Alzheimer disease. Results of this review have been recently published. This report is part of a larger project on the risks and benefits of HRT prepared for the U.S. Preventive Services Task Force to assist them in making recommendations. Between 3 and 8 million people in the United States have dementia. The most common type of dementia is Alzheimer disease, which affects 3 to 4 million people and is the fourth leading cause of death in the United States. The incidence of dementia is 1 percent per year in older individuals, although in the most elderly populations this rate may be as high as 2 to 3 percent. One community-based prevalence study in east Boston estimated that almost 50 percent of those aged 85 and over suffered from dementia. Most studies report that after accounting for differences in life expectancy, women have a 1.4 to 3-fold higher risk of Alzheimer disease than men. The life expectancy of demented patients is greatly reduced. Those with early-onset (before age 60) Alzheimer disease have a median survival of 6.7 to 8.1 years, while survival in those with late-onset disease is 4.8 to 6.0 years. In 1991, the annual cost of Alzheimer disease was estimated to be $67.3 billion. Given the expected growth of the elderly population, this financial cost, as well as the emotional and physical costs of caring for demented patients, will continue to increase. Observational data suggest a possible but inconsistent relationship between endogenous estrogen exposure and cognition. Women in the high estrogen phase of the menstrual cycle have been shown to perform better on tests of motor skills compared to when they are in the low estrogen phase of the cycle. Bone mineral density, hypothesized to be a marker of cumulative estrogen exposure, has been correlated with risk of cognitive deterioration. Because of the association between endogenous estrogen exposure and cognition, it can be hypothesized that hormone replacement therapy (HRT) after menopause may prevent cognitive decline and the development of dementia.


Neurodegeneration and Alzheimer's Disease

Neurodegeneration and Alzheimer's Disease
Author: Ralph N. Martins
Publisher: John Wiley & Sons
Total Pages: 548
Release: 2019-07-10
Genre: Technology & Engineering
ISBN: 1119356784

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Understanding the impact of diet, exercise, genetics, and hormones on the risk and development of Alzheimer’s and other neurogenerative diseases Diet is widely known to impact on neurological function. Nevertheless, academic texts discussing this relationship are relatively few in number. This book therefore fills an important gap in the current literature. Opening with an overview of neurodegenerative diseases, particularly Alzheimer’s disease, the text then focuses on explaining the means by which glycemic control and lipid metabolism – and associated nutritional and lifestyle variables – may factor into such disorders’ prevention and treatment. An international group of experts in the fields of food science and neurodegeneration have contributed chapters that examine Alzheimer’s disease within a broad range of contexts. Offering dietary, genetic, and hormonal perspectives, the authors explore topics ranging from sugar consumption to digestive fermentation, and Alzheimer’s disease animal models to the cognition-enhancing effects of physical exercise. Also included are overviews of the latest research into current and developing methods of treatment and diagnosis, as well as differential diagnostics. This groundbreaking book: Explores how glucose metabolism, insulin resistance, lipid metabolism, and high intake of refined carbohydrates are linked to Alzheimer's disease Discusses how genetic makeup can impact risk of Alzheimer’s and Parkinson’s disease Examines cognitive changes in neurodegeneration, lists current tests for determining cognitive impairment, and provides information concerning differential diagnosis Discusses potential advantages of increasing antioxidant and micronutrient intake Reviews hormonal influences on neurodegeneration Examines the links between protein intake and Alzheimer’s disease. Neurodegeneration and Alzheimer's Disease is an essential resource for researchers, medical practitioners, dietitians, and students with an interest in neurological diseases and their diagnosis and risk factors, as well as diet-related conditions such as diabetes and obesity. Lifestyle and diet influence neurodegeneration risk, and a better understanding of this evidence amongst health professionals will hopefully lead to greater public awareness of how to reduce the likelihood of these widespread conditions.


Sex and Gender Differences in Alzheimer's Disease

Sex and Gender Differences in Alzheimer's Disease
Author: Maria Teresa Ferretti
Publisher: Academic Press
Total Pages: 514
Release: 2021-07-23
Genre: Medical
ISBN: 012819345X

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Sex and Gender Differences in Alzheimer’s Disease: The Women’s Brain Project offers for the first time a critical overview of the evidence documenting sex and gender differences in Alzheimer’s disease neurobiology, biomarkers, clinical presentation, treatment, clinical trials and their outcomes, and socioeconomic impact on both patients and caregivers. This knowledge is crucial for clinical development, digital health solutions, as well as social and psychological support to Alzheimer’s disease families, in the frame of a precision medicine approach to Alzheimer’s disease.This book brings together up-to-date findings from a variety of experts, covering basic neuroscience, epidemiology, diagnosis, treatment, clinical trials development, socioeconomic factors, and psychosocial support. Alzheimer’s disease, the most common form of dementia, remains an unmet medical need for the planet. Wide interpersonal variability in disease onset, presentation, and biomarker profile make Alzheimer’s a clinical challenge to neuroscientists, clinicians, and drug developers alike, resulting in huge management costs for health systems and society. Not only do women represent the majority of Alzheimer’s disease patients, but they also represent two-thirds of caregivers. Understanding sex and gender differences in Alzheimer’s disease will lead to novel insights into disease mechanisms, and will be crucial for personalized disease management strategies and solutions, involving both the patient and their family. Endorsements/Reviews: "There is a clear sex and gender gap in outcomes for brain health disorders like Alzheimer’s disease, with strikingly negative outcomes for women. This understanding calls for a more systematic way of approaching this issue of inequality. This book effectively highlights and frames inequalities in all areas across the translational spectrum from bench-to-bedside and from boardroom-to-policy and economics. Closing the Brain Health Gap will help economies create recovery and prepare our systems for future global shocks." Harris A. Eyre MBBS, PhD, co-lead, Neuroscience-inspired Policy Initiative, OECD and PRODEO Institute. Instructor in Brain Health Diplomacy, Global Brain Health Institute, UCSF and TCD. "Sex and Gender Differences in Alzheimer's disease is the most important title to emerge on Alzheimer's disease in recent years.This comprehensive, multidisciplinary book is a must read for anyone with a serious interest in dementia prevention, diagnosis, treatment, care, cure and research. Precision medicine is the future of healthcare and this book represents an incredible and necessary resource to guide practice, policy and research in light of the fact that Alzheimer's disease disproportionately affects women. The combination of contributions from the most eminent experts and the most up-to-date research makes this an invaluable resource for clinicians, care providers, academics, researchers and policy makers. Given the complex nature of dementia and the multiple factors that influence risk and disease trajectory the scope of the book is both impressive and important covering sex differences in neurobiological processes, sex and gender differences in clinical aspects and gender differences linked to socioeconomic factors relevant to Alzheimer's disease. If you work in Alzheimer's disease, or indeed other dementias, then Sex and Gender Differences in Alzheimer's disease is a must have for your bookshelf." -- Sabina Brennan, PhD., C.Psychol.,PsSI., National representative for Ireland on Alzheimer Disease International's Medical and Scientific Advisory Panel


Reproductive Medicine for Clinical Practice

Reproductive Medicine for Clinical Practice
Author: Joseph G. Schenker
Publisher: Springer
Total Pages: 234
Release: 2018-09-29
Genre: Health & Fitness
ISBN: 3319780093

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This first volume of the series of the International Academy of Human Reproduction focuses on new aspects of reproductive medicine, from the professional responsibility model of ethics to the areas of high clinical involvement in human reproduction, such as endometriosis, polycystic ovary, family planning and post-coital contraception. The book discusses fertility and assisted reproductive techniques in the context of genetics and epigenetics as well as psychosomatic and longevity aspects. In addition, it presents new technologies and therapeutic strategies to improve IVF results and prevent ovarian hyperstimulation syndrome, as well the new challenges and the future of imaging in reproduction. Menopause and the effects of estrogens on atero-prevention, mood, and more generally the reproductive hormones impact on dementia and healthy aging are also covered. Further, it includes a section devoted to innovative aspects of gynecological surgery, discussing the treatments of vaginal aplasia, reproductive microsurgery and technological breakthroughs in pelvic organ prolapse surgery. Last, but not least, it examines the syndromic aspects of preterm birth. This volume is a useful and comprehensive tool for gynecologists, obstetricians, endocrinologists and all specialists who deal with women’s reproductive health.


The XX Brain

The XX Brain
Author: Lisa Mosconi PhD
Publisher: Penguin
Total Pages: 369
Release: 2022-11-08
Genre: Health & Fitness
ISBN: 0593542134

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The instant New York Times bestseller! "In The XX Brain, Lisa meticulously guides us in the ways we can both nourish and protect ourselves, body and mind, to ensure our brains remain resilient throughout our lives." --from the foreword by Maria Shriver The first book to address cognitive enhancement and Alzheimer's prevention specifically in women--and to frame brain health as an essential component of Women's Health. In this revolutionary book, Dr. Lisa Mosconi, director of the Women's Brain Initiative at Weill Cornell Medical College, provides women with the first plan to address the unique risks of the female brain. Until now, medical research has focused on "bikini medicine," assuming that women are essentially men with breasts and tubes. Yet women are far more likely than men to suffer from anxiety, depression, migraines, brain injuries, and strokes. They are also twice as likely to end their lives suffering from Alzheimer's disease, even when their longer lifespans are taken into account. But in the past, the female brain has received astonishingly little attention and was rarely studied by medical researchers-- resulting in a wealth of misinformation about women's health. The XX Brain confronts this crisis by revealing how the two powerful X chromosomes that distinguish women from men impact the brain first and foremost and by focusing on a key brain-protective hormone: estrogen. Taking on all aspects of women's health, including brain fog, memory lapses, depression, stress, insomnia, hormonal imbalances, and the increased risk of dementia, Dr. Mosconi introduces cutting-edge, evidence-based approaches to protecting the female brain, including a specific diet proven to work for women, strategies to reduce stress, and useful tips for restorative sleep. She also examines the controversy about soy and hormonal replacement therapy, takes on the perils of environmental toxins, and examines the role of our microbiome. Perhaps best of all, she makes clear that it is never too late to take care of yourself. The XX Brain is a rallying cry for women to have full access to information regarding what is going on in their brains and bodies as well as a roadmap for the path to optimal, lifelong brain health.


Sex Hormones in Neurodegenerative Processes and Diseases

Sex Hormones in Neurodegenerative Processes and Diseases
Author: Gorazd Drevensek
Publisher: BoD – Books on Demand
Total Pages: 360
Release: 2018-05-02
Genre: Medical
ISBN: 1789230144

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The book provides chapters on sex hormones and their modulation in neurodegenerative processes and pathologies, from basic molecular mechanisms, physiology, gender differences, to neuroprotection and clinical aspects for potential novel pharmacotherapy approaches. The book contains 14 chapters written by authors from various biomedical professions, from basic researchers in biology and physiology to medicine and veterinary medicine, pharmacologists, psychiatrist, etc. Chapters sum up the past and current knowledge on sex hormones, representing original new insights into their role in brain functioning, mental disorders and neurodegenerative diseases. The book is written for a broad range of audience, from biomedical students to highly profiled medical specialists and biomedical researchers, helping them to expand their knowledge on sex hormones in neurodegenerative processes and opening new questions for further investigation.