Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download High Mass Accuracy Analytical Applications Of Fourier Transform Ion Cyclotron Resonance Mass Spectrometry PDF full book. Access full book title High Mass Accuracy Analytical Applications Of Fourier Transform Ion Cyclotron Resonance Mass Spectrometry.
| Author | : Rebecca H. Wills |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2014 |
| Genre | : |
| ISBN | : |
| Author | : Rebecca Helen Wills |
| Publisher | : |
| Total Pages | : |
| Release | : 2014 |
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| Author | : Bruce Asamoto |
| Publisher | : Wiley-VCH |
| Total Pages | : 326 |
| Release | : 1991 |
| Genre | : Fourier transform spectroscopy |
| ISBN | : |
| Author | : Philippe Schmitt-Kopplin |
| Publisher | : Elsevier |
| Total Pages | : 778 |
| Release | : 2019-08-11 |
| Genre | : Science |
| ISBN | : 0128140143 |
Fundamentals and Applications of Fourier Transform Mass Spectrometry is the first book to delve into the underlying principles on the topic and their linkage to industrial applications. Drs. Schmitt-Kopplin and Kanawati have brought together a team of leading experts in their respective fields to present this technique from many different perspectives, describing, at length, the pros and cons of FT-ICR and Orbitrap. Numerous examples help researchers decide which instruments to use for their particular scientific problem and which data analysis methods should be applied to get the most out of their data. Covers FT-ICR-MS and Orbitrap’s fundamentals, enhancing researcher knowledge Includes details on ion sources, data processing, chemical analysis and imaging Provides examples across the wide spectrum of applications, including omics, environmental, chemical, pharmaceutical and food analysis
| Author | : B. Asamoto |
| Publisher | : Wiley |
| Total Pages | : 306 |
| Release | : 1991-11-11 |
| Genre | : Science |
| ISBN | : 9780471187349 |
An in-depth look at many of the applications where FT-ICR mass spectrometry is implemented. Contributing authors emphasize ways in which FT-ICR provides superior information to that of other types of mass spectrometers as well as where it may be less informative than other mass spectrometers. With the information provided, analytical chemists will be capable of assessing the usefulness of FT-ICR versus other mass spectrometric methods for their particular needs. Comprehensive chapters cover the history of ICR and other techniques based on the cyclotron principles of mass analysis and offer a descriptive explanation of the theory involved in fourier transform detection and analysis. Chapters also detail features and areas of active research in instrumentation and some specifications on commercial instruments as well as the home-built American Cyanamid instrument. Application chapters cover one technique in detail and illustrate its particular area of analysis.
| Author | : Oliver C. Mullins |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 677 |
| Release | : 2007-11-08 |
| Genre | : Science |
| ISBN | : 0387689036 |
With substantial contributions from experienced industrial scientists and engineers, this work will have real application towards improving process efficiency and improvement in the trillion-dollar global petroleum industry. It presents an overview of the emerging field of petroleomics, which endeavors to understand the fundamental components of crude oil. Petroleomics promises to revolutionize petroleum science in much the same way that genomics transformed the study of medicine not long ago. Asphaltenes are a particular focus, with many chapters devoted to the analysis of their structure and properties.
| Author | : Jennifer M. Hauschild |
| Publisher | : |
| Total Pages | : |
| Release | : 2011 |
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The past two decades have witnessed tremendous advances in the field of high accuracy, high mass resolution data acquisition of complex samples such as crude oils and the human proteome. With the development of Fourier transform ion cyclotron resonance mass spectrometry, the rapidly growing field of petroleomics has emerged, whose goal is to process and analyse the large volumes of complex and often poorly understood data on crude oils generated by mass spectrometry. As global oil resources deplete, oil companies are increasingly moving towards the extraction and refining of the still plentiful reserves of heavy, carbon rich and highly contaminated crude oil. It is essential that the oil industry gather the maximum possible amount of information about the crude oil prior to setting up the drilling infrastructure, in order to reduce processing costs. This project describes how machine learning can be used as a novel way to extract critical information from complex mass spectra which will aid in the processing of crude oils. The thesis discusses the experimental methods involved in acquiring high accuracy mass spectral data for a large and key industry-standard set of crude oil samples. These data are subsequently analysed to identify possible links between the raw mass spectra and certain physical properties of the oils, such as pour point and sulphur content. Methods including artificial neural networks and self organising maps are described and the use of spectral clustering and pattern recognition to classify crude oils is investigated. The main focus of the research, the creation of an original simulated annealing genetic algorithm hybrid technique (SAGA), is discussed in detail and the successes of modelling a number of different datasets using all described methods are outlined. Despite the complexity of the underlying mass spectrometry data, which reflects the considerable chemical diversity of the samples themselves, the results show that physical properties can be modelled with varying degrees of success. When modelling pour point temperatures, the artificial neural network achieved an average prediction error of less than 10% while SAGA predicted the same values with an average accuracy of more than 85%. It did not prove possible to model any of the other properties with such statistical significance; however improvements to feature extraction and pre-processing of the spectral data as well as enhancement of the modelling techniques should yield more consistent and statistically reliable results. These should in due course lead to a comprehensive model which the oil industry can use to process crude oil data using rapid and cost effective analytical methods.
| Author | : Konstantin Aizikov |
| Publisher | : |
| Total Pages | : 240 |
| Release | : 2010 |
| Genre | : |
| ISBN | : |
Abstract: Mass spectrometry imaging (MSI) is an emerging experimental methodology whose primary objective is the investigation of spatial variation of molecular composition within and across selected biological tissues to enable biomarker discovery, molecular diagnosis, and studies of drug metabolism, among other applications. The two major challenges, therefore, are the unambiguous identification and precise localization of biologically relevant compounds. These challenges can be recast as a problem of improving the accuracy and resolution of mass analyzers as well as the accuracy of the sample positioning robotics. The first part of this work reports on the progress and outlines the strategies of application of a recently developed high resolution spectral analysis technique, called the Filter Diagonalization Method (FDM), for the investigation of space-charge related phenomena inside the detection cell of a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer (FT-ICR MS), understanding of which lies at the heart of the quest for further improvements in mass accuracy and resolution. The FDM spectrographic analysis revealed previously unobserved rapid isotope- beat space-charge induced ICR frequency modulations, shown to reach up to +/- 400 ppm even on high quality spectra. The application of this methodology to the investigation of a frequently observed but previously unexplained phenomenon in FT-ICR MS, the Spontaneous Loss of Coherence Catastrophe, conclusively demonstrated that it is tied directly to the space charge effect and magnetron expansion. The second part of this work reports on the development of the ionization source and vacuum compatible high precision sample positioning robotics for biological MSI applications, purpose built for FT-ICR MS. The complete design and implementation is reported herein, along with the demonstration of its performance and biological application. The XY-positioning stage capable of operating under 10 -8 mbar vacuum with submicron positioning accuracy along the entire ranges of motion of 100x100 mm was designed, built, and installed into the ionization sources of three MALDI FT-ICR MS instruments. Two dimensional chemo-spatial maps of rat brain tissue selections were constructed with 150 micron spatial resolution, identifying multiple ionic species with their distinct and discreet spatial localizations. These demonstrated performance characteristics greatly surpass current state-of-the-art robotics available for MALDI MSI and shift the effort of further improvements in spatial resolution to the ionization methodologies, and other ion source design issues, such as laser optics.
| Author | : Pawel Ciborowski |
| Publisher | : Elsevier |
| Total Pages | : 300 |
| Release | : 2016-03-02 |
| Genre | : Science |
| ISBN | : 0444636900 |
Proteomic Profiling and Analytical Chemistry: The Crossroads, Second Edition helps scientists without a strong background in analytical chemistry to understand principles of the multistep proteomic experiment necessary for its successful completion. It also helps researchers who do have an analytical chemistry background to break into the proteomics field. Highlighting points of junction between proteomics and analytical chemistry, this resource links experimental design with analytical measurements, data analysis, and quality control. This targeted point of view will help both biologists and chemists to better understand all components of a complex proteomic study. The book provides detailed coverage of experimental aspects such as sample preparation, protein extraction and precipitation, gel electrophoresis, microarrays, dynamics of fluorescent dyes, and more. The key feature of this book is a direct link between multistep proteomic strategy and quality control routinely applied in analytical chemistry. This second edition features a new chapter on SWATH-MS, substantial updates to all chapters, including proteomic database search and analytical quantification, expanded discussion of post-hoc statistical tests, and additional content on validation in proteomics. Covers the analytical consequences of protein and peptide modifications that may have a profound effect on how and what researchers actually measure Includes practical examples illustrating the importance of problems in quantitation and validation of biomarkers Helps in designing and executing proteomic experiments with sound analytics
| Author | : Tzu-Yung Lin |
| Publisher | : |
| Total Pages | : |
| Release | : 2012 |
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| ISBN | : |
With the development of mass spectrometry (MS) instruments starting in the late 19th century, more and more research emphasis has been put on MS related subjects, especially the instrumentation and its applications. Instrumentation research has led modern mass spectrometers into a new era where the MS performance, such as resolving power and mass accuracy, is close to its theoretical limit. Such advanced performance releases more opportunities for scientists to conduct analytical research that could not be performed before. This thesis reviews general MS history and some of the important milestones, followed by introductions to ion cyclotron resonance (ICR) technique and quadrupole operation. Existing electronic designs, such as Fourier-transform ion cyclotron resonance (FT-ICR) preamplifiers (for ion signal detection) and radio-frequency (RF) oscillators (for ion transportation/filtering) are reviewed. Then the potential scope for improvement is discussed. Two new FT-ICR preamplifiers are reported; both preamplifiers operate at room temperature. The first preamplifier uses an operational amplifier (op amp) in a transimpedance configuration. When a 18-k feedback resistor is used, this preamplifier delivers a transimpedance of about 85 dB , and an input current noise spectral density of around 1 pA/ p Hz. The total power consumption of this circuit is around 310 mW when tested on the bench. This preamplifier has a bandwidth of fi3 kHz to 10 MHz, which corresponds to the mass-to-charge ratio, m/z, of approximately 18 to 61k at 12 T for FT-ICR MS. The transimpedance and the bandwidth can be adjusted by replacing passive components such as the feedback resistor and capacitor. The feedback and bandwidth limitation of the circuit is also discussed. When using an 0402 type surface mount resistor, the maximum possible transimpedance, without sacrificing its bandwidth, is approximated to 5.3 M . Under this condition, the preamplifier is estimated to be able to detect ~110 charges. The second preamplifier employs a single-transistor design using a different feedback arrangement, a T-shaped feedback network. Such a feedback system allows ~100-fold less feedback resistance at a given transimpedance, hence preserving bandwidth, which is beneficial to applications demanding high gain. The single-transistor preamplifier yields a low power consumption of ~5.7 mW, and a transimpedance of 80 dB in the frequency range between 1 kHz and 1 MHz (m/z of around 180 to 180k for a 12-T FT-ICR system). In trading noise performance for higher transimpedance, an alternative preamplifier design has also been presented with a transimpedance of 120 dB in the same frequency range. The previously reported room-temperature FT-ICR preamplifier had a voltage gain of about 25, a bandwidth of around 1 MHz when bench tested, and a voltage noise spectral density of ~7.4 nV/ p Hz. The bandwidth performance when connecting this preamplifier to an ICR cell has not been reported. However, from the transimpedance theory, the transimpedance preamplifiers reported in this work will have a bandwidth wider by a factor of the open-loop gain of the amplifier. In a separate development, an oscillator is proposed as a power supply for a quadrupole mass filter in a mass spectrometer system. It targets a stabilized output frequency, and a feedback control for output amplitude stabilization. The newly designed circuit has a very stable output frequency at 1 MHz, with a frequency tolerance of 15 ppm specified by the crystal oscillator datasheet. Within this circuit, an automatic gain control (AGC) unit is built for output amplitude stabilisation. A new transformer design is also proposed. The dimension of the quadrupole being used as a mass filter will be determined in the future. This circuit (in particular the transformer and the quadrupole connection/mounting device) will be finalised after the design of the quadrupole. Finally, this thesis concludes with a discussion between the gain and the noise performance of an FT-ICR preamplifier. A brief analysis about the correlation between the gain, cyclotron frequency, and input capacitance is performed. Future work is also suggested for extending this research.
