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Heterocycles as Chiral Auxiliaries in Asymmetric Synthesis

Heterocycles as Chiral Auxiliaries in Asymmetric Synthesis
Author: Manfred Braun
Publisher: Springer Nature
Total Pages: 326
Release: 2020-12-08
Genre: Science
ISBN: 3030453049

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The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field. All chapters from Topics in Heterocyclic Chemistry are published Online First with an individual DOI. In references, Topics in Heterocyclic Chemistry is abbreviated as Top Heterocycl Chem and cited as a journal.


Asymmetric Synthesis of Nitrogen Heterocycles

Asymmetric Synthesis of Nitrogen Heterocycles
Author: Jacques Royer
Publisher: John Wiley & Sons
Total Pages: 425
Release: 2009-08-04
Genre: Science
ISBN: 3527625518

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Here, all aspects of the topic are presented in a compact manner. The book is clearly structured, and divided into two sections -- asymmetric synthesis of heterocycles containing only one nitrogen and that of those with more than one nitrogen as a heteroatom -- such that the necessary information may be found at a glance. The international team of authors provides important experimental procedures, including industrial applications. Essential for synthetic chemists in pharmaceutical and agrochemical chemistry.


Asymmetric Synthesis of Three-Membered Rings

Asymmetric Synthesis of Three-Membered Rings
Author: Hélène Pellissier
Publisher: John Wiley & Sons
Total Pages: 610
Release: 2017-03-28
Genre: Science
ISBN: 3527802010

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The first handbook to focus on the asymmetric synthesis of different types of three-membered rings. The outstanding and experienced authors have an excellent international reputation and cover cyclopropanes, epoxides and aziridines as well as chiral oxaziridines in equal measure. To this end, they describe in detail different synthetic approaches starting with chiral substrates as well as the application of chiral metal- or organocatalysts. Furthermore, methods for the kinetic resolution of initially racemic products are treated alongside recent advances and novel developments in established techniques for the synthesis of three-membered rings. With its structured composition this is of high interest to scientists in methodological and natural product synthesis as well as those in industrial and pharmaceutical chemistry.


Chiral Auxiliaries and Ligands in Asymmetric Synthesis

Chiral Auxiliaries and Ligands in Asymmetric Synthesis
Author: J. Seyden-Penne
Publisher: Wiley-Interscience
Total Pages: 744
Release: 1995-10-23
Genre: Science
ISBN:

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Table of Contents Preface Abbreviations Introduction 1 1 Enantiomerically Pure Chiral Auxiliaries 43 2 Chiral Reagents 87 3 Chiral Catalysis and Catalysts Bearing Chiral Ligands 117 4 Asymmetric Deprotonations and Protonations 143 5 Alkylations and Related Reactions 157 6 Additions to C=O and C=N Double Bonds 209 7 Additions to Carbon-Carbon Double Bonds 367 8 Additions to Double Bonds Bearing Heteroatoms. Oxidations of Sulfides and Selenides 503 9 Cycloadditions 513 10 Sigmatropic Rearrangements 593 11 Transition Metal Catalyzed Reactions 619 References 637 Index 707.


Chiral Building Blocks in Asymmetric Synthesis

Chiral Building Blocks in Asymmetric Synthesis
Author: Jacek Wojaczynski
Publisher: John Wiley & Sons
Total Pages: 692
Release: 2022-08-05
Genre: Science
ISBN: 3527834192

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Chiral Building Blocks in Asymmetric Synthesis A comprehensive introduction to the important classes of chiral building blocks Chirality — the asymmetric quality found in certain chemical compounds — plays an essential role in our world: chiral compounds can be found in biology, pharmaceutical compounds, agrochemicals, and fragrances. The stereoselective preparation of these complex molecular constructions constitutes a challenge. To this end, modern asymmetric synthesis utilizes a variety of valuable and efficient reagents employed as chiral auxiliaries, metal complexes and organocatalysts in stereoselective catalysis, and enantiopure reactants termed as chiral building blocks. In Chiral Building Blocks in Asymmetric Synthesis, the achievements in the fields of preparation of and applications of chiral blocks are presented. In doing so, the book comprehensively discusses the important classes of these reactants as the key for the asymmetric synthesis of chiral molecules. As such, it is an indispensable resource about synthetic methods, as well as possible modifications and transformations of important classes of chiral compounds. It also highlights the importance of their use as reactants and auxiliaries in the preparation of more sophisticated molecules or supramolecular systems. In Chiral Building Blocks in Asymmetric Synthesis readers will also find: Organization according to the most important compound classes — e.g. amino acids, BINOL and its derivatives, terpenes, and others — with an emphasis on synthesis and application A focus on the use of chiral building blocks for the preparation of bioactive compounds and supramolecular assemblies Chiral Building Blocks in Asymmetric Synthesis is a useful reference for organic chemists, catalytic chemists, chemists in industry, medicinal chemists, pharmaceutical chemists, and the libraries that support them.


Heterocycles in Natural Product Synthesis

Heterocycles in Natural Product Synthesis
Author: Krishna C. Majumdar
Publisher: John Wiley & Sons
Total Pages: 648
Release: 2011-06-15
Genre: Science
ISBN: 3527634894

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Filling a gap on the market, this handbook and ready reference is unique in its discussion of the usefulness of various heterocyclic systems in the synthesis of natural products. Clearly structured for easy access to the information, each chapter is devoted to a certain class of heterocycle, providing a tabular presentation of the natural products to be covered containing the particular heterocyclic ring system along with their biological profile, occurrence and most important physical properties, backed by the appropriate references. In addition, the application of the heterocyclic system to the synthesis of natural products ic covered in detail. Of great interest to organic, natural products, medicinal and biochemists, as well as those working in the pharmaceutical and agrochemical industry.


Synthesis of Saturated Oxygenated Heterocycles I

Synthesis of Saturated Oxygenated Heterocycles I
Author: Janine Cossy
Publisher: Springer
Total Pages: 288
Release: 2014-03-14
Genre: Science
ISBN: 3642414737

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The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field.


Synthetic and Stereochemical Aspects

Synthetic and Stereochemical Aspects
Author: Philip Page
Publisher: Academic Press
Total Pages: 325
Release: 1997-10-17
Genre: Science
ISBN: 0080538207

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The impact of organosulfur chemistry, especially in the areas of heterocyclic chemistry, stereocontrolled processes, and asymmetric synthesis, has led to a resurgence of interest in the field. This book is the secondin a series intended to provide coverage of topics of current interest throughout the whole range of organosulfur chemistry. Each volume is comprised of five or six chapters, each consisting of an in-depth, self-contained review in a well-defined area. This volume and its predecessor Organosulfur Chemistry, Synthetic Aspects will prove valuable references for researchers and practitioners in organic chemistry. Methods of asymmetric sulfur oxidation processes Preparation of chiral sulfoxides in nucleophilic displacement at sulfur Conformational preferences of the sulfinyl group Preparation and chemistry of unsaturated sulfoxides Applications of sulfoxides as stereocontrol elements The chemistry of sulfolenes


Raney Nickel-Assisted Synthesis of Heterocycles

Raney Nickel-Assisted Synthesis of Heterocycles
Author: Navjeet Kaur
Publisher: Elsevier
Total Pages: 232
Release: 2022-04-04
Genre: Science
ISBN: 0323994938

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Raney Nickel-Assisted Synthesis of Heterocycles covers the synthesis of heterocycles using Raney nickel. The book focuses on the use of Raney-Ni, a common catalyst in hydrogenation reaction and its uses in the synthesis and preparation of heterocycles. Furthermore, it explains how the development of new approaches and strategic deployments in known approaches for the formation of complex heterocyclic compounds continue to drive the field of synthetic organic chemistry, along with updates on efforts to prepare heterocycles through the development of new and efficient synthetic transformations. Heterocyclic chemistry is an inexhaustible source of novel compounds, providing the most diverse chemical, physical and biological properties through the design of a wide range of combinations of carbon, hydrogen and heteroatoms. Significant focus has been paid to novel approaches to the formation of heterocyclic compounds, which are of practical use acting as modifiers and additives in a wide range of industries such as reprography, plastics, cosmetics, vulcanization accelerators, solvents, antioxidants and information storage. Presents complete coverage of Raney Nickel assisted reactions Includes the discovery, reactivities, advantages, disadvantages and other characteristics of Raney nickel Presents new methodologies for the synthesis of heterocycles