Handbook Of Essential Pharmacokinetics Pharmacodynamics And Drug Metabolism For Industrial Scientists PDF Download
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| Author | : Younggil Kwon |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 302 |
| Release | : 2007-05-08 |
| Genre | : Medical |
| ISBN | : 0306468204 |
Download Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists Book in PDF, ePub and Kindle
In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization. During discovery phases, the identifi- tion of the critical PK/PD/DM issues of new compounds plays an essential role in understanding their pharmacological profiles and structure-activity relationships. Owing to recent progress in analytical chemistry, a large number of compounds can be screened for their PK/PD/DM properties within a relatively short period of time. During development phases as well, the toxicology and clinical study designs and trials of a compound should be based on a thorough understanding of its PK/PD/DM properties. During my time as an industrial scientist, I realized that a reference work designed for practical industrial applications of PK/PD/DM could be a very valuable tool for researchers not only in the pharmacokinetics and drug metabolism departments, but also for other discovery and development groups in pharmaceutical companies. This book is designed specifically for industrial scientists, laboratory assistants, and managers who are involved in PK/PD/DM-related areas. It consists of thirteen chapters, each of which deals with a particular PK/PD/DM issue and its industrial applications. Chapters 3 and 12 in particular address recent topics on higher throughput in vivo exposure screening and the prediction of pharmacokinetics in humans, respectively. Chapter 8 covers essential information on drug metabolism for industrial scientists.
| Author | : Thorsteinn Loftsson |
| Publisher | : Academic Press |
| Total Pages | : 179 |
| Release | : 2015-03-25 |
| Genre | : Medical |
| ISBN | : 0128014911 |
Download Essential Pharmacokinetics Book in PDF, ePub and Kindle
Essential Pharmacokinetics: A Primer for Pharmaceutical Scientists is an introduction to the concepts of pharmacokinetics intended for graduate students and new researchers working in the pharmaceutical sciences. This book describes the mathematics used in the mammillary model as well as the application of pharmacokinetics to pharmaceutical product development, and is useful as both a self-study and classroom resource. Content coverage includes detailed discussions of common models and important pharmacokinetic concepts such as biological half-life, clearance, excretion, multiple dosage regimens and more. Numerous equations, practical examples and figures are incorporated to clearly illustrate the theoretical background of pharmacokinetic behavior of drugs and excipients. Shows how to apply basic pharmacokinetic methods to evaluate drugs, excipients and drug products Uses guided practice questions, mathematical concepts and real-world examples for self-assessment and retention purposes Illustrates how to write and evaluate drug registration files
| Author | : Sara E. Rosenbaum |
| Publisher | : John Wiley & Sons |
| Total Pages | : 589 |
| Release | : 2016-12-27 |
| Genre | : Medical |
| ISBN | : 1119143152 |
Download Basic Pharmacokinetics and Pharmacodynamics Book in PDF, ePub and Kindle
Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also features interactive computer simulations for students to experiment and observe PK/PD models in action. • Presents the essentials of pharmacokinetics and pharmacodynamics in a clear and progressive manner • Helps students better appreciate important concepts and gain a greater understanding of the mechanism of action of drugs by reinforcing practical applications in both the book and the computer modules • Features interactive computer simulations, available online through a companion website at: https://web.uri.edu/pharmacy/research/rosenbaum/sims/ • Adds new chapters on physiologically based pharmacokinetic models, predicting drug-drug interactions, and pharmacogenetics while also strengthening original chapters to better prepare students for more advanced applications • Reviews of the 1st edition: “This is an ideal textbook for those starting out ... and also for use as a reference book ...." (International Society for the Study of Xenobiotics) and “I could recommend Rosenbaum’s book for pharmacology students because it is written from a perspective of drug action . . . Overall, this is a well-written introduction to PK/PD .... “ (British Toxicology Society Newsletter)
| Author | : Mehdi Boroujerdi |
| Publisher | : CRC Press |
| Total Pages | : 780 |
| Release | : 2023-08-22 |
| Genre | : Medical |
| ISBN | : 1000878430 |
Download Handbook of Pharmacokinetics and Toxicokinetics Book in PDF, ePub and Kindle
This fully revised and expanded volume is an effort to blend the common approaches to pharmacokinetics and toxicokinetics. It integrates the principles held in common by both fields through a logical and systematic approach, which includes mathematical descriptions of physical and physiological processes employed in the approaches to pharmacokinetics and toxicokinetics modeling. It emphasizes general principles and concepts and related, isolated applications and case study observations. The systematic compilation of mathematical concepts and methodologies allows readers to decide on relevant concepts and approaches for their research, scientific or regulatory decisions, or for offering advanced courses/workshops and seminars. Features: Comprehensive handbook on principles and applications of PK/TK appealing to a diverse audience including scientists and students An excellent text fully revised and fully updated for anyone interested in the theoretical and practical pharmacokinetics The systematic compilation of mathematical concepts and methodologies allows readers to decide on relevant concepts and approaches for their research Incorporates research relevant to SDGs and of interest to industrial and regulatory environmental scientists involved in chemical contamination research and regulatory decision making related to soil, water, and ocean Includes sections on applications and case studies
| Author | : Siamak Cyrus Khojasteh |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 222 |
| Release | : 2011-04-07 |
| Genre | : Medical |
| ISBN | : 1441956298 |
Download Drug Metabolism and Pharmacokinetics Quick Guide Book in PDF, ePub and Kindle
Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.
| Author | : Paul G. Pearson |
| Publisher | : CRC Press |
| Total Pages | : 0 |
| Release | : 2008-11-18 |
| Genre | : Medical |
| ISBN | : 9781420076479 |
Download Handbook of Drug Metabolism, Second Edition Book in PDF, ePub and Kindle
This timely, expanded new edition is the definitive handbook for experienced drug metabolism and pharmaceutical scientists and those new to the field. Written by internationally renowned authors, it provides integrated, comprehensive coverage of fundamental aspects of drug metabolism and the practical applications that help guide researchers through key challenges in modern drug discovery and development. The Second Edition covers the many recent scientific and technical advances in the field, and is organized in four sections – ideal for use in undergraduate and graduate programs in Drug Metabolism and Clinical Pharmacology: fundamental aspects of drug metabolism factors that affect drug metabolism new enabling technologies to study drug metabolism applications of metabolism studies in drug development and drug discovery
| Author | : Hartmut Derendorf |
| Publisher | : CRC Press |
| Total Pages | : 483 |
| Release | : 2019-06-12 |
| Genre | : |
| ISBN | : 9780367228033 |
Download Handbook of Pharmacokinetic/Pharmacodynamic Correlation Book in PDF, ePub and Kindle
First published in 1995: Combining the established disciplines of pharmacokinetics (PK), the relationship between drug concentration and time, and pharmacodynamics (PD), the relationship between drug effects and concentration, this handbook examines the relevant relationship between drug effects and time.
| Author | : Rajesh Krishna |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 556 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 1441992162 |
Download Applications of Pharmacokinetic Principles in Drug Development Book in PDF, ePub and Kindle
This volume is an important advancement in the application ofpharmacokinetic (PK) and pharmacodynamic (PO) principles to . drug development. The series of topics presented deal with the application of these tools to everyday decisions that a pharmaceutical scientist encounters. The ability to integrate these topics using PK and PO methods has optimized drug development pathways in the clinic. New technologies in the areas of in vitro assays that are more predictive of human absorption and metabolism and advancement in bioanalytical assays are leading the way to minimize drug failures in later, more expensive clinical development programs. of Pharmacokinetics and pharmacodynamics have become an important component understanding the drug action on the body and is becoming increasingly important in drug labeling due to it's potential for predicting drug behavior in populations that may be difficult to study in adequate numbers during drug development. The ability to correlate drug exposure to effect and model it during the drug development value chain provides valuable insight into optimizing the next steps to derive maximum information from each study. These principles and modeling techniques have resulted in an expanded and integrated view of PK and PO and have led to the expectations that we may be able to optimally design clinical trials and eventually lead us to identifying the optimal therapy for the patient, while minimizing cost and speeding up drug development. There is wide utility for the book both as a text and as a reference.
| Author | : Thomas Woolf |
| Publisher | : CRC Press |
| Total Pages | : 612 |
| Release | : 2019-08-30 |
| Genre | : |
| ISBN | : 9780367399856 |
Download Handbook of Drug Metabolism Book in PDF, ePub and Kindle
Bringing together nearly forty collaborators from academic and industrial laboratories, this reference furnishes an overview of the subject from a historical, kinetic, and chemical context. A source of expertise for a rapidly changing and expanding field, the book provides a framework for drug metabolism in drug discovery and development. Containing tables, drawings, photographs, and equations, it highlights the importance of pharmacokinetics and cytochrome P450, explains clearance, volume of distribution, sequential metabolism, and nonlinear kinetics, summarizes concepts of Phase 1 and 2 metabolites, evaluates tertiary amine metabolism and reactive metabolite chemistry, and more.
| Author | : Wolfgang A. Ritschel |
| Publisher | : American Pharmacists Association (APhA) |
| Total Pages | : 456 |
| Release | : 2004 |
| Genre | : Medical |
| ISBN | : |
Download Handbook of Basic Pharmacokinetics-- Including Clinical Applications Book in PDF, ePub and Kindle
A user-friendly handbook on the principles and techniques involved in the various applications of pharmacokinetics. Provides a concise reference for clinicians who need quick information on the pharmacokinetic characteristics of specific drugs. Thoroughly updated and revised, this book features pharmacokinetic data profiles on more than 600 drugs.
