Glycosignals In Cancer Mechanisms Of Malignant Phenotypes PDF Download

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Glycosignals in Cancer: Mechanisms of Malignant Phenotypes

Glycosignals in Cancer: Mechanisms of Malignant Phenotypes
Author: Koichi Furukawa
Publisher: Springer
Total Pages: 218
Release: 2016-01-26
Genre: Science
ISBN: 4431559396

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This book is a collection of cutting-edge studies on the functions and mechanisms of glycosylation in cancers. Along with progress in genomics and proteomics, new findings in the significance of these complex carbohydrates, through the regulation of cell signals, have been elucidated in a wide variety of biological events. This volume provides a comprehensive summary of glycosignals and their involvement in cancer, covering numerous topics such as glycosylation machineries, regulation of phenotypes, cell signaling, immune regulation, complex carbohydrate organization, and clinical applications. The contents have been organized to promote ready understanding, covering basic to clinical research and studies on micromolecules, to animal/human cells and tissues. This book is an essential read for students and young researchers interested in cancers and carbohydrates. Specialists in glycobiology will also benefit from the new results and approaches detailed here, which provide insights into future directions of functional studies of sugar chains in both basic and applied research.


Glycosignals in Cancer

Glycosignals in Cancer
Author: Koichi Furukawa
Publisher: Springer Nature
Total Pages: 234
Release: 2023-03-20
Genre: Medical
ISBN: 9811977321

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This book, now in an extensively revised second edition, provides a comprehensive summary of the latest knowledge regarding glycosignals and a thorough analysis of their involvement in not only cancers but also other refractory conditions such as chronic inflammatory disorders. Many relevant topics are covered, including the search for novel tumor epitopes related to carbohydrates, the assembly of glycoconjugates, the modulation of signaling pathways by glycosylation, and interactions between complex carbohydrates and their recognition molecules. The role of various research approaches, for example advanced mass spectrometry, high-resolution imaging, and bioinformatics, is closely examined, and the results of novel therapeutic trials targeting glycosignals are discussed. The book will be essential reading for students and young researchers with an interest in glycoscience. In presenting new results and approaches and identifying areas for future research, it will also be of benefit for specialists in the field.


The Big Book on Small Heat Shock Proteins

The Big Book on Small Heat Shock Proteins
Author: Robert M. Tanguay
Publisher: Springer
Total Pages: 603
Release: 2015-06-15
Genre: Medical
ISBN: 331916077X

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Based upon a workshop entitled “The Small HSP World” held in Québec 2-5 October 2014. Twenty-five scientists provided chapters for the book. The chapters are from the best scientists currently working in this field. These colleagues include Arrigo, Benesch, Benjamin, Buchner-Haslbeck-Weinkauf, Benndorf, Boelens, Carra, Chang, Currie, Ecroyd, Emanuelsson, Fu, Garrido, Golenhofen, Gusev, Hightower, Kampinga, Lavoie, MacRae, Quinlan, Tanguay, Vierling, Vigh, Weeks and Wu. Briefly, the book starts with the structure of small heat shock proteins, moving to their functions and finishing with their involvement in diseases. Although this is quite broad, the structural aspect will be the unifying theme of the book.


Carbohydrate-based Drug Discovery

Carbohydrate-based Drug Discovery
Author: Chi-Huey Wong
Publisher: John Wiley & Sons
Total Pages: 980
Release: 2006-03-06
Genre: Science
ISBN: 3527605789

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To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > Chemical Synthesis of Carbohydrates > Carbohydrate Biosynthesis and Metabolism > Carbohydrate Analysis > Cellular Functions of Carbohydrates > Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world's leading carbohydrate chemists.


Glycobiology

Glycobiology
Author:
Publisher: Academic Press
Total Pages: 651
Release: 2010-10-25
Genre: Science
ISBN: 0123810000

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In this 3 volume collection focusing on glycomics, readers will appreciate how such discoveries were made and how such methods can be applied for readers’ own research efforts Each chapter has been designed so that enough scientific background will be given in each chapter for further development of methods by readers themselves Useful for all levels of scientists starting from the last years of colleges, graduate students, postdoctoral fellows to professors and to all levels of scientists in research institutes including industry


Advances in MALDI and Laser-Induced Soft Ionization Mass Spectrometry

Advances in MALDI and Laser-Induced Soft Ionization Mass Spectrometry
Author: Rainer Cramer
Publisher: Springer
Total Pages: 287
Release: 2015-11-09
Genre: Science
ISBN: 3319048198

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This book covers the state-of-the-art of modern MALDI (matrix-assisted laser desorption/ionization) and its applications. New applications and improvements in the MALDI field such as biotyping, clinical diagnosis, forensic imaging, and ESI-like ion production are covered in detail. Additional topics include MS imaging, biotyping/speciation and large-scale, high-speed MS sample profiling, new methods based on MALDI or MALDI-like sample preparations, and the advantages of ESI to MALDI MS analysis. This is an ideal book for graduate students and researchers in the field of bioanalytical sciences. This book also: • Showcases new techniques and applications in MALDI MS • Demonstrates how MALDI is preferable to ESI (electrospray ionization) • Illustrates the pros and cons associated with biomarker discovery studies in clinical proteomics and the various application areas, such as cancer proteomics


Clinical Applications for Next-Generation Sequencing

Clinical Applications for Next-Generation Sequencing
Author: Urszula Demkow
Publisher: Academic Press
Total Pages: 336
Release: 2015-09-10
Genre: Science
ISBN: 0128018410

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Clinical Applications for Next Generation Sequencing provides readers with an outstanding postgraduate resource to learn about the translational use of NGS in clinical environments. Rooted in both medical genetics and clinical medicine, the book fills the gap between state-of-the-art technology and evidence-based practice, providing an educational opportunity for users to advance patient care by transferring NGS to the needs of real-world patients. The book builds an interface between genetic laboratory staff and clinical health workers to not only improve communication, but also strengthen cooperation. Users will find valuable tactics they can use to build a systematic framework for understanding the role of NGS testing in both common and rare diseases and conditions, from prenatal care, like chromosomal abnormalities, up to advanced age problems like dementia. Fills the gap between state-of-the-art technology and evidence-based practice Provides an educational opportunity which advances patient care through the transfer of NGS to real-world patient assessment Promotes a practical tool that clinicians can apply directly to patient care Includes a systematic framework for understanding the role of NGS testing in many common and rare diseases Presents evidence regarding the important role of NGS in current diagnostic strategies


Case Files

Case Files
Author: Eugene C. Toy
Publisher:
Total Pages: 488
Release: 2008
Genre: Clinical biochemistry
ISBN: 9780071278201

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Carbohydrate Chemistry

Carbohydrate Chemistry
Author: Amelia Pilar Rauter
Publisher: Royal Society of Chemistry
Total Pages: 276
Release: 2017-12-12
Genre: Reference
ISBN: 1788010035

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Carbohydrate Chemistry demonstrates the interdisciplinary nature of modern carbohydrate research, and benefits any researcher who wishes to learn about the latest developments in the carbohydrate field.


Biological Adhesives

Biological Adhesives
Author: Andrew M. Smith
Publisher: Springer Science & Business Media
Total Pages: 296
Release: 2007-01-12
Genre: Science
ISBN: 3540310495

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Many creatures use adhesive polymers and structures to attach to inert substrates, to each other, or to other organisms. This is the first major review that brings together research on many of the well-known biological adhesives dealing with bacteria, fungi, algae, and marine and terrestrial animals. As we learn more about their molecular and mechanical properties we begin to understand why they adhere so well and with this comes broad applications in areas such as medicine, dentistry, and biotechnology.