Genomic Approaches For Cross Species Extrapolation In Toxicology PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Genomic Approaches For Cross Species Extrapolation In Toxicology PDF full book. Access full book title Genomic Approaches For Cross Species Extrapolation In Toxicology.
Author | : William H. Benson |
Publisher | : CRC Press |
Total Pages | : 218 |
Release | : 2006-12-13 |
Genre | : Mathematics |
ISBN | : 1420043641 |
Download Genomic Approaches for Cross-Species Extrapolation in Toxicology Book in PDF, ePub and Kindle
The latest tools for investigating stress response in organisms, genomic technologies provide great insight into how different organisms respond to environmental conditions. However, their usefulness needs to be tested, verified, and codified. Genomic Approaches for Cross-Species Extrapolation in Toxicology provides a balanced discussion drawn from
Author | : Society of Environmental Toxicology & Chemistry |
Publisher | : S E T A C Press |
Total Pages | : 187 |
Release | : 2006-12 |
Genre | : |
ISBN | : 9781880611883 |
Download Genomic Approaches for Cross-Species Extrapolation in Toxicology Book in PDF, ePub and Kindle
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 58 |
Release | : 2006-04-24 |
Genre | : Science |
ISBN | : 0309181682 |
Download Application of Toxicogenomics to Cross-Species Extrapolation Book in PDF, ePub and Kindle
Some of what we know about the health effects of exposure to chemicals from food, drugs, and the environment come from studies of occupational, inadvertent, or accident-related exposures. When there is not enough human data, scientists rely on animal data to assess risk from chemical exposure and make health and safety decisions. However, humans and animals can respond differently to chemicals, including the types of adverse effects experienced and the dosages at which they occur. Scientists in the field of toxicogenomics are using new technologies to study the effects of chemicals. For example, in response to a particular chemical exposure, they can study gene expression ("transcriptomics"), proteins ("proteomics") and metabolites ("metabolomics"), and they can also look at how individual and species differences in the underlying DNA sequence itself can result in different responses to the environment. Based on a workshop held in August 2004, this report explores how toxicogenomics could enhance scientists' ability to make connections between data from experimental animal studies and human health.
Author | : Gerald Ankley |
Publisher | : CRC Press |
Total Pages | : 198 |
Release | : 2007-11-27 |
Genre | : Science |
ISBN | : 1420066838 |
Download Genomics in Regulatory Ecotoxicology Book in PDF, ePub and Kindle
Fueled partially by large, well-publicized efforts such as the Human Genome Project, genomic research is a rapidly growing area in multiple biological disciplines, including toxicology. Much of this potential, however, has been discussed in the literature and at technical meetings only in relatively broad terms, making it difficult to assess exactl
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 300 |
Release | : 2007-12-19 |
Genre | : Science |
ISBN | : 0309112982 |
Download Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment Book in PDF, ePub and Kindle
The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.
Author | : Edward J. Perkins |
Publisher | : Elsevier Inc. Chapters |
Total Pages | : 39 |
Release | : 2013-06-04 |
Genre | : Medical |
ISBN | : 0128060484 |
Download Computational Toxicology Book in PDF, ePub and Kindle
New concepts in toxicology facilitate the use of nonmammalian vertebrate species (e.g., fish) and nonanimal models (nonvertebrates, early embryo vertebrates, or cell-based) as surrogates for mammals. We present a strategy to translate nonmammalian species data to estimate potential impact of chemicals on mammalian species based on highly conserved proteins and biological pathways linked to a defined adverse effect. Protein “targets” and pathway-level information can be mapped across species through identification of orthologs in mammals. Nonmammalian pathway data can be used to identify potential modes of action across species, establish toxicological dose-response relationships, and be used to estimate possible hazard levels of chemicals. Systems-level approaches are identified that offer unique opportunities to incorporate dynamic events such as homeostasis, effects over time, and species-specific parameters relevant to mammals. Ultimately, a pathway-centric focus enables use of alternative models to support protection of mammalian species.
Author | : |
Publisher | : |
Total Pages | : 0 |
Release | : 2005 |
Genre | : Genetic toxicology |
ISBN | : 9780309656160 |
Download Application of Toxicogenomics to Cross-species Extrapolation Book in PDF, ePub and Kindle
Considers strategies for communicating toxicogenomic information to the public and other non-expert audiences, specifically addressing the communication of some key social, ethical, and legal issues related to toxicogenomics and addressing how information related to the social implications of toxicogenomics might be perceived by nonexperts.
Author | : Kunal Roy |
Publisher | : John Wiley & Sons |
Total Pages | : 596 |
Release | : 2022-01-06 |
Genre | : Science |
ISBN | : 1119681596 |
Download Chemometrics and Cheminformatics in Aquatic Toxicology Book in PDF, ePub and Kindle
CHEMOMETRICS AND CHEMINFORMATICS IN AQUATIC TOXICOLOGY Explore chemometric and cheminformatic techniques and tools in aquatic toxicology Chemometrics and Cheminformatics in Aquatic Toxicology delivers an exploration of the existing and emerging problems of contamination of the aquatic environment through various metal and organic pollutants, including industrial chemicals, pharmaceuticals, cosmetics, biocides, nanomaterials, pesticides, surfactants, dyes, and more. The book discusses different chemometric and cheminformatic tools for non-experts and their application to the analysis and modeling of toxicity data of chemicals to various aquatic organisms. You’ll learn about a variety of aquatic toxicity databases and chemometric software tools and webservers as well as practical examples of model development, including illustrations. You’ll also find case studies and literature reports to round out your understanding of the subject. Finally, you’ll learn about tools and protocols including machine learning, data mining, and QSAR and ligand-based chemical design methods. Readers will also benefit from the inclusion of: A thorough introduction to chemometric and cheminformatic tools and techniques, including machine learning and data mining An exploration of aquatic toxicity databases, chemometric software tools, and webservers Practical examples and case studies to highlight and illustrate the concepts contained within the book A concise treatment of chemometric and cheminformatic tools and their application to the analysis and modeling of toxicity data Perfect for researchers and students in chemistry and the environmental and pharmaceutical sciences, Chemometrics and Cheminformatics in Aquatic Toxicology will also earn a place in the libraries of professionals in the chemical industry and regulators whose work involves chemometrics.
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 58 |
Release | : 2006-05-24 |
Genre | : Science |
ISBN | : 0309100844 |
Download Application of Toxicogenomics to Cross-Species Extrapolation Book in PDF, ePub and Kindle
Some of what we know about the health effects of exposure to chemicals from food, drugs, and the environment come from studies of occupational, inadvertent, or accident-related exposures. When there is not enough human data, scientists rely on animal data to assess risk from chemical exposure and make health and safety decisions. However, humans and animals can respond differently to chemicals, including the types of adverse effects experienced and the dosages at which they occur. Scientists in the field of toxicogenomics are using new technologies to study the effects of chemicals. For example, in response to a particular chemical exposure, they can study gene expression ("transcriptomics"), proteins ("proteomics") and metabolites ("metabolomics"), and they can also look at how individual and species differences in the underlying DNA sequence itself can result in different responses to the environment. Based on a workshop held in August 2004, this report explores how toxicogenomics could enhance scientists' ability to make connections between data from experimental animal studies and human health.
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 422 |
Release | : 2009-03-24 |
Genre | : Political Science |
ISBN | : 0309120462 |
Download Science and Decisions Book in PDF, ePub and Kindle
Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.