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Genome Chaos

Genome Chaos
Author: Henry H. Heng
Publisher: Academic Press
Total Pages: 556
Release: 2019-05-25
Genre: Medical
ISBN: 0128136367

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Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macro-evolution. In authoring this thought-provoking text, Dr. Heng invigorates fresh discussions in genome theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine. Bridges basic research and clinical application and provides a foundation for re-examining the results of large-scale omics studies and advancing molecular medicine Gathers the most pressing questions in genomic and cytogenomic research Offers alternative explanations to timely puzzles in the field Contains eight evidence-based chapters that discuss 4d-genomics, genes and genomes as distinct biological entities, genome chaos and macro-cellular evolution, evolutionary cytogenetics and cancer, chromosomal coding and fuzzy inheritance, and more


Genetic Entropy & the Mystery of the Genome

Genetic Entropy & the Mystery of the Genome
Author: John C. Sanford
Publisher: Ivan Press
Total Pages: 228
Release: 2005
Genre: Science
ISBN:

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Dr. John Sanford, a retired Cornell Professor, shows in Genetic Entropy and the Mystery of the Genome that the Primary Axiom is false. The Primary Axiom is the foundational evolutionary premise - that life is merely the result of mutations and natural selection. In addition to showing compelling theoretical evidence that whole genomes can not evolve upward, Dr. Sanford presents strong evidence that higher genomes must in fact degenerate over time. This book strongly refutes the Darwinian concept that man is just the result of a random and pointless natural process.


Nonlinear Workbook, The: Chaos, Fractals, Cellular Automata, Genetic Algorithms, Gene Expression Programming, Support Vector Machine, Wavelets, Hidden Markov Models, Fuzzy Logic With C++, Java And Symbolicc++ Programs (6th Edition)

Nonlinear Workbook, The: Chaos, Fractals, Cellular Automata, Genetic Algorithms, Gene Expression Programming, Support Vector Machine, Wavelets, Hidden Markov Models, Fuzzy Logic With C++, Java And Symbolicc++ Programs (6th Edition)
Author: Willi-hans Steeb
Publisher: World Scientific Publishing Company
Total Pages: 683
Release: 2014-11-14
Genre: Science
ISBN: 9814583499

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The Nonlinear Workbook provides a comprehensive treatment of all the techniques in nonlinear dynamics together with C++, Java and SymbolicC++ implementations. The book not only covers the theoretical aspects of the topics but also provides the practical tools. To understand the material, more than 100 worked out examples and 160 ready to run programs are included. Each chapter provides a collection of interesting problems. New topics added to the 6th edition are Swarm Intelligence, Quantum Cellular Automata, Hidden Markov Model and DNA, Birkhoff's ergodic theorem and chaotic maps, Banach fixed point theorem and applications, tau-wavelets of Haar, Boolean derivatives and applications, and Cartan forms and Lagrangian.


Emergence

Emergence
Author: John H. Holland
Publisher: OUP Oxford
Total Pages: 276
Release: 2000
Genre: Science
ISBN: 9780192862112

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We are confronted with emergent systems everywhere and Holland shows how a theory of emergence can predict many complex behaviours in art and science. This book will appeal to scientists and anyone interested in scientific theory.


Debating Cancer

Debating Cancer
Author: Henry H. Heng
Publisher: World Scientific
Total Pages: 463
Release: 2015-10-08
Genre: Science
ISBN: 9814520853

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"Cancer research is at a crossroads. Traditionally, cancer has been thought of as a disease of gene mutation, where the stepwise accumulation of cancer gene mutations is the key, and the identification of common gene mutations has been considered to be essential for diagnosis and treatment. Despite extensive research efforts and accumulated knowledge on cancer genes and pathways, the clinical benefits of this traditional approach have been limited. Recently, cancer genome sequencing has revealed an extensive amount of genetic heterogeneity where the long-expected common mutation drivers have been difficult, if not impossible, to identify. These realities ultimately challenge the conceptual framework of current cancer biology. This book introduces a new concept of genome theory of cancer evolution, in an attempt to unify the field. Many important and representative, but often confusing, questions and paradoxes are critically analyzed. By comparing gene- and genome-based theories, the hidden flaws of many popular viewpoints are addressed. This discussion is intended to initiate a much-needed critical re-evaluation of current cancer research."--


The Chaos Machine

The Chaos Machine
Author: Max Fisher
Publisher: Hachette UK
Total Pages: 419
Release: 2022-09-06
Genre: Social Science
ISBN: 0316703311

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Finalist for the Helen Bernstein Book Award for Excellence in Journalism From a New York Times investigative reporter, this “authoritative and devastating account of the impacts of social media” (New York Times Book Review) tracks the high-stakes inside story of how Big Tech’s breakneck race to drive engagement—and profits—at all costs fractured the world. The Chaos Machine is “an essential book for our times” (Ezra Klein). We all have a vague sense that social media is bad for our minds, for our children, and for our democracies. But the truth is that its reach and impact run far deeper than we have understood. Building on years of international reporting, Max Fisher tells the gripping and galling inside story of how Facebook, Twitter, YouTube, and other social network preyed on psychological frailties to create the algorithms that drive everyday users to extreme opinions and, increasingly, extreme actions. As Fisher demonstrates, the companies’ founding tenets, combined with a blinkered focus on maximizing engagement, have led to a destabilized world for everyone. Traversing the planet, Fisher tracks the ubiquity of hate speech and its spillover into violence, ills that first festered in far-off locales, to their dark culmination in America during the pandemic, the 2020 election, and the Capitol Insurrection. Through it all, the social-media giants refused to intervene in any meaningful way, claiming to champion free speech when in fact what they most prized were limitless profits. The result, as Fisher shows, is a cultural shift toward a world in which people are polarized not by beliefs based on facts, but by misinformation, outrage, and fear. His narrative is about more than the villains, however. Fisher also weaves together the stories of the heroic outsiders and Silicon Valley defectors who raised the alarm and revealed what was happening behind the closed doors of Big Tech. Both panoramic and intimate, The Chaos Machine is the definitive account of the meteoric rise and troubled legacy of the tech titans, as well as a rousing and hopeful call to arrest the havoc wreaked on our minds and our world before it’s too late.


Genome

Genome
Author: Matt Ridley
Publisher: Harper Collins
Total Pages: 370
Release: 2013-03-26
Genre: Science
ISBN: 0062253468

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“Ridley leaps from chromosome to chromosome in a handy summation of our ever increasing understanding of the roles that genes play in disease, behavior, sexual differences, and even intelligence. . . . . He addresses not only the ethical quandaries faced by contemporary scientists but the reductionist danger in equating inheritability with inevitability.” — The New Yorker The genome's been mapped. But what does it mean? Matt Ridley’s Genome is the book that explains it all: what it is, how it works, and what it portends for the future Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life. Genome offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications of gene therapy to the horrors of eugenics, Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.


Mapping and Sequencing the Human Genome

Mapping and Sequencing the Human Genome
Author: National Research Council
Publisher: National Academies Press
Total Pages: 128
Release: 1988-01-01
Genre: Science
ISBN: 0309038405

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There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.


Life's Ratchet

Life's Ratchet
Author: Peter M. Hoffmann
Publisher:
Total Pages: 290
Release: 2012-10-30
Genre: Science
ISBN: 0465022537

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Life, Hoffman argues, emerges from the random motions of atoms filtered through the sophisticated structures of our evolved machinery. People are essentially giant assemblies of interacting nanoscale machines.


Genetic Algorithms and Investment Strategies

Genetic Algorithms and Investment Strategies
Author: Richard J. Bauer
Publisher: John Wiley & Sons
Total Pages: 324
Release: 1994-03-31
Genre: Business & Economics
ISBN: 9780471576792

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When you combine nature's efficiency and the computer's speed, thefinancial possibilities are almost limitless. Today's traders andinvestment analysts require faster, sleeker weaponry in today'sruthless financial marketplace. Battles are now waged at computerspeed, with skirmishes lasting not days or weeks, but mere hours.In his series of influential articles, Richard Bauer has shown whythese professionals must add new computerized decision-making toolsto their arsenal if they are to succeed. In Genetic Algorithms andInvestment Strategies, he uniquely focuses on the most powerfulweapon of all, revealing how the speed, power, and flexibility ofGAs can help them consistently devise winning investmentstrategies. The only book to demonstrate how GAs can workeffectively in the world of finance, it first describes thebiological and historical bases of GAs as well as othercomputerized approaches such as neural networks and chaos theory.It goes on to compare their uses, advantages, and overallsuperiority of GAs. In subsequently presenting a basic optimizationproblem, Genetic Algorithms and Investment Strategies outlines theessential steps involved in using a GA and shows how it mimicsnature's evolutionary process by moving quickly toward anear-optimal solution. Introduced to advanced variations ofessential GA procedures, readers soon learn how GAs can be usedto: * Solve large, complex problems and smaller sets of problems * Serve the needs of traders with widely different investmentphilosophies * Develop sound market timing trading rules in the stock and bondmarkets * Select profitable individual stocks and bonds * Devise powerful portfolio management systems Complete with information on relevant software programs, a glossaryof GA terminology, and an extensive bibliography coveringcomputerized approaches and market timing, Genetic Algorithms andInvestment Strategies unveils in clear, nontechnical language aremarkably efficient strategic decision-making process that, whenimaginatively used, enables traders and investment analysts to reapsignificant financial rewards.