Gene Therapy Of Autoimmune Disease PDF Download
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Author | : Gerald J. Prud'homme |
Publisher | : Springer Science & Business Media |
Total Pages | : 148 |
Release | : 2007-02-26 |
Genre | : Medical |
ISBN | : 0387286705 |
Download Gene Therapy of Autoimmune Disease Book in PDF, ePub and Kindle
Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs. Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.
Author | : Yuti Chernajovsky |
Publisher | : Springer Science & Business Media |
Total Pages | : 249 |
Release | : 2011-01-28 |
Genre | : Medical |
ISBN | : 3034601654 |
Download Gene Therapy for Autoimmune and Inflammatory Diseases Book in PDF, ePub and Kindle
In this monograph about gene therapy of autoimmune and inflammatory d- orders we have gathered international experts and leaders from different fields to review the state of the art advances on topics ranging from disease entities to vectors and engineered cells. The different approaches described in each chapter take into consideration the biomedical knowledge of these diseases and address the complexities of delivering long-term genetic interventions. Gene therapy also serves as a testing ground for new therapeutic entities and helps provide proof of principle for their potential therapeutic role in animal models of disease. Scaling up from mice to men still remains an important h- dle not only from the quantitative point of view, but also for currently unknown and unexpected secondary effects of the vector or the transgene. Some of these approaches have already been tested in the clinic, but much more needs to be done to understand the human conditions treated and the n- ural history of their pathology. We are indebted to the secretarial assistance of Ms. Lin Wells (Bone and Joint Research Unit, London, UK) and the help of Hans Detlef Klüber for his help in getting this book published. We hope this book will be of interest to c- nicians and scientists and inspiring to students of the subject who will use their own ingenuity and knowledge to further forward this discipline into clinical use.
Author | : C. Garrison Fathman |
Publisher | : Karger Medical and Scientific Publishers |
Total Pages | : 229 |
Release | : 2000-01-01 |
Genre | : Medical |
ISBN | : 3805569491 |
Download Biologic and Gene Therapy of Autoimmune Disease Book in PDF, ePub and Kindle
The clinical management of autoimmune diseases has proven to be extremely difficult. Current therapies focus on trying to alleviate symptoms, but fail to correct the fundamental immune defects that lead to pathology. To achieve this goal, it is necessary to understand much of the biology of antigen presentation, lymphocyte activation and the effects of cytokines. The articles in this book provide an up-to-date review of current innovative therapies using both biologic and gene therapy for the treatment of selected autoimmune diseases. Therapeutical approaches discussed include oral tolerance, the use of anti-CD4 monoclonal antibodies, IL-10 and anti-TNFa antibodies, DNA vaccination, and gene therapy applied to organ-specific autoimmune disease. Although some of these techniques are still in their infancy, their potential efficacy has been demonstrated in several animal models of autoimmune disease, holding great promise for the future development of treatments. Written by recognized experts in the field, the chapters in this book illustrate the concept of technology transfer from bench to bedside and provide a valuable update for clinicians and scientists in clinical immunology.
Author | : Gerald J. Prud'homme |
Publisher | : Springer |
Total Pages | : 149 |
Release | : 2005-07-13 |
Genre | : Medical |
ISBN | : 9780306479915 |
Download Gene Therapy of Autoimmune Disease Book in PDF, ePub and Kindle
Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs. Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.
Author | : Dagan (NA) Wells |
Publisher | : |
Total Pages | : |
Release | : 2003-01-01 |
Genre | : Medical |
ISBN | : 9781587062056 |
Download Gene Therapy for Autoimmune Disease Book in PDF, ePub and Kindle
Author | : Christopher H. Evans |
Publisher | : Birkhäuser |
Total Pages | : 278 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3034884788 |
Download Gene Therapy in Inflammatory Diseases Book in PDF, ePub and Kindle
Gene therapy for inflammatory diseases is a new , burgeoning field of medicine. Edited by the undisputed pioneers of this area of research, this volume is the first devoted to its topic. It contains thirteen chapters, each written by leaders in their respective fields, that summarize the state of the art in developing novel, gene based treatments for inflammatory diseases. As well as providing an introduction to the basic concepts of gene therapy and the use of naked DNA approaches, the book describes the advances that have been made in applying them to arthritis, lupus, multiple sclerosis, diabetes, Sjogren`s syndrome and transplantation.One chapter is devoted to discussing the first human clinical trials that apply gene therapy to the treatment of an inflammatory disease. As well as providing novel therapeutic approaches, gene therapy facilitates the development of new and improved animal models of disease; a chapter describing these advances is also included. As an up-to-date, timely book written by th
Author | : Gerald J. Prud'homme |
Publisher | : Springer |
Total Pages | : 0 |
Release | : 2008-11-01 |
Genre | : Medical |
ISBN | : 9780387500164 |
Download Gene Therapy of Autoimmune Disease Book in PDF, ePub and Kindle
Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs. Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.
Author | : Nicholas R. Lemoine |
Publisher | : |
Total Pages | : 99 |
Release | : 2003 |
Genre | : Autoimmune diseases |
ISBN | : |
Download Gene Therapy for Autoimmune Disease Book in PDF, ePub and Kindle
Author | : Gina Lynn Costa |
Publisher | : |
Total Pages | : 336 |
Release | : 2000 |
Genre | : |
ISBN | : |
Download Retroviral-based Gene Therapy in Autoimmune Disease Book in PDF, ePub and Kindle
Author | : C. Pozzilli |
Publisher | : Springer Science & Business Media |
Total Pages | : 158 |
Release | : 2013-06-29 |
Genre | : Medical |
ISBN | : 3662044501 |
Download New Concepts in Pathology and Treatment of Autoimmune Disorders Book in PDF, ePub and Kindle
Autoimmunity, characterized by autoreactive lymphocytes and autoantibodies, is the consequence of a failure to discriminate between self and non-self, and autoimmune diseases are an increasing threat to people living in the industrialized countries. Autoimmune disorders are treatable, but not curable, and patients can face disability at later stages of the disease. Thus, there is a medical and economic need for new concepts and treatments in autoimmune disorders. New concepts and treatments can only be achieved by an interdisciplinary approach bringing together expertise, technologies, and clinical experience. The workshop focused on multiple sclerosis, rheumatoid arthritis and type I diabetes, and discussed conventional drug therapies, gene therapy, cell and tissue transplantation therapies, and first treatments using blood stem cells for reprogramming the patients' immune system.