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Fungal Biofilms and related infections

Fungal Biofilms and related infections
Author: Christine Imbert
Publisher: Springer
Total Pages: 129
Release: 2016-08-09
Genre: Science
ISBN: 3319423606

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This book covers the latest data available to understand the mechanisms causing the formation of single species fungal biofilms or polymicrobial biofilms involving fungal species; specific chapters present hot topics such as resistance mechanisms and composition and role of the matrix. Moreover, it reviews updated data on biofilms that contain yeasts or filamentous fungi and develop in the human body or in water and may cause infections. The latest available data for both diagnostic and treatment of infections associated to fungi growing in biofilms is also presented. The activity of antifungal and disinfectant agents against fungal biofilms is discussed in specific chapters and future treatments on natural sources are suggested. This book bridges the gap between basic and applied research. It is the result of many years of research work done by laboratories worldwide, all known for their expertise on fungal biofilms.


Fungal Biofilms 2020

Fungal Biofilms 2020
Author: Celia F. Rodrigues
Publisher: Mdpi AG
Total Pages: 0
Release: 2022-10-11
Genre:
ISBN: 9783036554181

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Fungal infections are an important and increasing global threat, carrying not only high morbidity and mortality rates, but also high healthcare costs. Without an effective response, it is predicted that 10 million people will die per year as a result of multi-drug-resistant pathogens. A high percentage of the mortalities caused by fungi are known to be biofilm-related. This Special Issue, "Fungal Biofilms 2020", is intended to cover the state of fungal biofilm research, from virulence and pathogenicity, to new compounds with antibiofilm and antifungal activity. We welcome reviews and original research articles covering the development/evaluation/validation of recent studies, especially those regarding multidrug resistance.


Biomaterial-Related Infections

Biomaterial-Related Infections
Author: Natália Martins
Publisher: MDPI
Total Pages: 204
Release: 2020-12-23
Genre: Medical
ISBN: 3039434381

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The use of medical devices (e.g., catheters, implants, and probes) is a common and essential part of medical care for both diagnostic and therapeutic purposes. However, these devices quite frequently lead to the incidence of infections due to the colonization of their abiotic surfaces by biofilm-growing microorganisms, which are progressively resistant to antimicrobial therapies. Several methods based on anti-infective biomaterials that repel microbes have been developed to combat device-related infections. Among these strategies, surface coating with antibiotics (e.g., beta-lactams), natural compounds (e.g., polyphenols), or inorganic elements (e.g., silver and copper nanoparticles) has been widely recognized as exhibiting broad-spectrum bactericidal or bacteriostatic activity. So, in order to achieve a better therapeutic response, it is crucial to understand how these infections are different from others. This will allow us to find new biomaterials characterized by antifouling coatings with repellent properties or low adhesion towards microorganisms, or antimicrobial coatings that are capable of killing microbes approaching the surface, improving biomaterial functionalization strategies and supporting tissues’ bio-integration.


Polymicrobial Diseases

Polymicrobial Diseases
Author: Kim A. Brogden
Publisher:
Total Pages: 460
Release: 2002
Genre: Bacteria
ISBN:

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Polymicrobial diseases, those involving more than one etiologic agent, are more common than is generally realized and include respiratory diseases, gastroenteritis, conjunctivitis, keratitis, hepatitis, periodontal diseases, multiple sclerosis, genital infections, intra -- abdominal infections, and pertussis.


Fungal Pathogenicity

Fungal Pathogenicity
Author: Sadia Sultan
Publisher: BoD – Books on Demand
Total Pages: 140
Release: 2016-05-11
Genre: Technology & Engineering
ISBN: 9535123947

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This book is specially written for researchers at various levels, for example, in forestry, agriculture, industry, university and college laboratories. It describes the fungal pathogenicity; resistance behavior of fungal biofilms and its mechanisms; different categories of fungal infection and colonization patterns with example relevant to soybean; characteristics of white rob of corncob and head smut of maize such as cycle, pathogenicity factors, control methods, the abilities of chitosan and its derivatives to elicit resistance reactions in plants and its action in the production and viability of fungal spores; and the mode of actions of single constituents of different essential oils depending on different case studies. In addition, this book also describes the importance of synthetic peptides as an alternative tool for the diagnosis of cryptococcosis. Finally, a survey of fungal diseases occurring on trees of Namibia is described. This survey is the first dedicated step to find ways of protecting them from disease-causing agents.


Biofilm-based Healthcare-associated Infections

Biofilm-based Healthcare-associated Infections
Author: Gianfranco Donelli
Publisher: Springer
Total Pages: 197
Release: 2014-11-10
Genre: Medical
ISBN: 3319097822

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The aim of this book is to provide readers with a wide overview of the main healthcare-associated infections caused by bacteria and fungi able to grow as biofilm. The recently acquired knowledge on the pivotal role played by biofilm-growing microorganisms in healthcare-related infections has given a new dynamic to detection, prevention and treatment of these infections in patients admitted to both acute care hospitals and long-term care facilities. Clinicians, hygienists and microbiologists will be updated by leading scientists on the state-of-art of biofilm-based infections and on the most innovative strategies for prevention and treatment of these infections, often caused by emerging multidrug-resistant biofilm-growing microorganisms.


Microbial Biofilms

Microbial Biofilms
Author: Mahmoud Ghannoum
Publisher: John Wiley & Sons
Total Pages: 404
Release: 2020-08-11
Genre: Science
ISBN: 1555817467

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An examination of the research and translational application to prevent and treat biofilm-associated diseases In the decade since the first edition of Microbial Biofilms was published, the interest in this field has expanded, spurring breakthrough research that has advanced the treatment of biofilm-associated diseases. This second edition takes the reader on an exciting, extensive review of bacterial and fungal biofilms, ranging from basic molecular interactions to innovative therapies, with particular emphasis on the division of labor in biofilms, new approaches to combat the threat of microbial biofilms, and how biofilms evade the host defense. Chapters written by established investigators cover recent findings, and contributions from investigators new to the field provide unique and fresh insights. Specifically, Microbial Biofilms provides state-of-the-art research in the field of bacterial and fungal biofilms detailed descriptions of the in vitro and in vivo models available to evaluate microbial biofilms future areas of research and their translational and clinical applications Microbial Biofilms is a useful reference for researchers and clinicians. It will also provide insight in the dynamic field of microbial biofilms for graduate and postgraduate students.


Antifungal Drug Discovery: New Theories and New Therapies

Antifungal Drug Discovery: New Theories and New Therapies
Author: Chaminda Jayampath Seneviratne
Publisher: Frontiers Media SA
Total Pages: 138
Release: 2016-09-13
Genre: Microbiology
ISBN: 2889199509

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Fungal infections such as candidoses can range from superficial mucous membrane infection to life-threatening systemic mycoses. Candida infections are a significant clinical problem globally due to rapid rise in compromised host populations including HIV/AIDS, organ transplant recipients and patients on chemotherapy. In addition, sharp increase in aging populations which are susceptible to fungal infections is expected in next few decades. Antifungal drugs are relatively difficult to develop compared to the antibacterial drugs owing to the eukaryotic nature of the cells. Therefore, only a handful of antifungal agents are currently available to treat the myriad of fungal infections. Moreover, rising antifungal resistance and host-related adverse reactions have limited the antifungal arsenal against fungal pathogens. In this research topic, we tried to update the theoretical aspects pertaining to the antifungal drug discovery i.e. proposed novel mechanisms, new drug targets and pathways. In addition, invited authors explored the new antifungal drugs derived from natural and synthetic sources which are currently under development. Contributors were encouraged to bring new insight into the antifungal drug discovery. We hope the reader may arrive at a general consensus on the possible strategies to combat ever increasing ubiquitous fungal infection in this new century.


Candida and Candidiasis

Candida and Candidiasis
Author: Richard A. Calderone
Publisher: American Society for Microbiology Press
Total Pages: 1222
Release: 2011-12-07
Genre: Medical
ISBN: 1555815391

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The underlying mechanisms of Candida and candidiasis and promising new directions in drug discovery and treatment. • Reviews all aspects of this common fungal pathogen and its impact on human health, from the basic biology of Candida albicans to the clinical management of candidiasis. • Reviews the latest basic and clinical research, focusing on findings in genome variability, host-pathogen interactions, antifungal resistance and drug discovery, and diagnostics to foster better understanding and treatment of candidiasis. • Examines recent discoveries that have shed light on morphogenesis and the cell cycle, including how new findings on host responses may have applications for the diagnosis of blood-borne candidiasis.


Microbial Biofilms

Microbial Biofilms
Author: Chaminda Jayampath Seneviratne
Publisher: CRC Press
Total Pages: 334
Release: 2017-07-12
Genre: Medical
ISBN: 1351646427

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Microbial Biofilms: Omics Biology, Antimicrobials and Clinical Implications is a comprehensive survey of microbial biofilms and their role in human health and disease with contributions from world renowned experts in molecular microbiology, proteomics, genomics, metabolomics and infectious diseases. The book is intended to serve as a guide for students, as well as a reference for researchers, clinicians and industry professionals. The chapters cover bacterial and fungal microbiomes, and the latest omics techniques organized in a clear and up-to-date manner. One of the highlights of this book is the comprehensive information on "omics of microbial biofilms". The chapters dedicated to metagenomics, proteomics and metabolomics are designed to provide a simple and holistic review of the current knowledge and, the applications of these techniques in the field of microbial biofilms. In addition to introductory chapters on microbial biofilms and their clinical implications, subsequent chapters delve into oral biofilms, their composition, and metagenomic diversity. Thereafter, mechanisms of drug resistance in microbial biofilms are reviewed, as well as the proteomic and metabolomic characterization of this resistance. The book includes a comprehensive discussion of persister cells and host–microbial interactions on mucosal surfaces. Finally, the book concludes with a summary of novel therapeutic approaches for biofilms such as synbiotics and biogenics.